DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and cdh4

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_571161.2	Gene:	cdh4 / 30297	ZFINID:	ZDB-GENE-991207-1	Length:	931	Species:	Danio rerio

Alignment Length:	941	Identity:	235/941 - (24%)
Similarity:	358/941 - (38%)	Gaps:	224/941 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SPPYF----DRFLYETEIDENADLQSTVLT------VNAKD----HNESTNIRYQITGGNIGNAF 82
            |.|.|    |..||       |:...|.||      |.|:|    :...|.::..:.|..:...|
Zfish    84 SDPKFSVRPDGSLY-------AEQDVTNLTEPIQFMVTARDRAGEYIWETTVKLALAGHPLSPPF 141

  Fly    83 AVQNTTGVIYVASPLDYE-------TRPRYELR--LEATRNRKNNYTTVVINVRDVNDNPPVFDR 138
              ....|......|..|.       |.||...|  ....|.:|.::....|||.:.:..|
Zfish   142 --NQIAGEAIYGGPSHYHYQNPRLITFPRQRQRGLSNGLRRQKRDWVIPPINVPENSRGP----- 199

  Fly   139 QTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFV 203
                          .|:.::.:.:   |.|:.|.|.|.:||.|  .|.|.|..|:|:..||.:.|
Zfish   200 --------------FPQVLVMIRS---DQDKKIEIRYSITGAG--ADQPPNDVFNIDPVTGKMSV 245

  Fly   204 LKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAG 268
            .|||||:.   |..:.....|.|..|..:....|:.:.:.|:|||.|:|...:|.|:|.|....|
Zfish   246 TKPLDRED---RASYHLKAHAVDINGNQMEPPIDLYIYVIDMNDNRPEFKNQVYNGSVAEGSKPG 307

  Fly   269 SSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPI---FEIEPETGLIKTAVCCLDRERTP 330
            :|||.::|.|.||   ||.|..:  :...::.:....||   |.|...||.|.|....:|||:..
Zfish   308 TSVMQVTAFDADD---STTANGL--VHYRILSQTPHIPIPNMFTINGATGEISTIAAGIDREKVS 367

  Fly   331 DYS--IQVVAMDGG---GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVT 390
            .|:  :|...|:|.   ||..|.||.|.:.|:||.||:.....::.||.|.....:    :..:|
Zfish   368 QYTVIVQATDMEGNLNFGLSNTATALISISDINDNPPELDSKTFLGEVPENAVGVV----VANLT 428

  Fly   391 VQDEDETNTFQYKVVPNSGFGADKFA--MVRNGDGT--GSLKIIQPLDYEDPLQSSGFRFRIQVN 451
            |:|:|:.:|..:..|... .|.|...  .:|..:.|  |.:.:::|:|||   ::..|...:.|:
Zfish   429 VRDKDQPHTPNWNAVYRI-TGGDPLGHFTIRTDEITNDGRVIVVKPVDYE---RNGAFMLMVVVS 489

  Fly   452 DKG------DDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKAT 510
            ::.      ...|..|       :.|.:.:.|:|: .|.|......:...|.....|.|..|.|.
Zfish   490 NQAHLASGIPSSPSSS-------AGVTITVLDVNE-APVFPSNPKIIRFEEGVPADTTLATFAAL 546

  Fly   511 DADQGGHSKVAY----------KIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDD 565
            |.|:.....:.|          ||.|:..|....|:.||.:..:::.:...|       .||:|:
Zfish   547 DPDRFIQQTIRYSKLSDPANWLKINRTNGRITTTAVLDRESPYMKKNVYEAT-------FLAVDN 604

  Fly   566 GSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRL 630
            |||..|.|.||.:.:.|||||.|............:..|..: .:.|.|.|.  ..|.||:.|.|
Zfish   605 GSPPATGTGTLQIYLIDVNDNVPVLVPQEALVCERSRHGYPV-NITASDLDS--EPNAGPYVFEL 666

  Fly   631 DPLASDEIKAGFKVEYDRRG---DNENGVAIISSLR-PFDREAQKSYAIPIEIKDNGAPAMTGTS 691
            ....|..          ||.   ...||......|| |:.....  |.:||.:.|:|.|.::.||
Zfish   667 PSYPSSA----------RRNWTISRLNGNYAQLKLRIPYLEAGM--YRVPILVSDSGNPPLSNTS 719

  Fly   692 TLTVTIGDVNDNKMQPGSKSVL---------------------------------VYNYQGQSQD 723
            .|.|.:...::|    |..:|:                                 |...:.:.|.
Zfish   720 VLKVKVCPCDEN----GDCTVIGAVTVAGLGTGAIITILICIIILLSMVLFFVVWVKRREKERQT 780

  Fly   724 TPIGRVYVNDPDDWDVPDK--KYYWE--VQEHQRFKL------DTDTGILTMRAGTRR------- 771
            .|:    :.||:| ||.|.  ||..|  .:|.|.:.|      ::...|::..||.||
Zfish   781 KPL----LIDPED-DVRDNILKYDEEGGGEEDQDYDLSQLQQPESLDHIMSKPAGVRRVDERPVI 840

  Fly   772 --GRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQ------------AGSM-----RLSHI 817
              .:|.:|..|.......|.|...|.....|.||.....            |||:     ..|..
Zfish   841 LESQYPVRPTVPHPGDIGEFITDGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLDSSSSGE 905

  Fly   818 TDEDFVRTWNPVKNQVEPSKLERFRNKLAEL 848
            .|.|::..|.|           ||: |||:|
Zfish   906 QDYDYLNDWGP-----------RFK-KLADL 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	23/109 (21%)
		Cadherin_repeat	140..248	CDD:206637	29/107 (27%)
		Cadherin_repeat	256..359	CDD:206637	37/110 (34%)
		Cadherin_repeat	379..481	CDD:206637	22/111 (20%)
		Cadherin_repeat	489..586	CDD:206637	29/106 (27%)
		Cadherin_repeat	594..703	CDD:206637	27/112 (24%)
		Cadherin_repeat	724..801	CDD:206637	24/95 (25%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
cdh4	NP_571161.2	Cadherin_pro	34..128	CDD:214999	14/50 (28%)
		E_set	187..287	CDD:298831	33/126 (26%)
		Cadherin_repeat	295..402	CDD:206637	38/111 (34%)
		Cadherin_repeat	414..517	CDD:206637	24/117 (21%)
		Cadherin_repeat	532..625	CDD:206637	29/99 (29%)
		Cadherin	632..726	CDD:278457	27/108 (25%)
		Cadherin_C	784..926	CDD:279398	40/154 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5001
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010