DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN2 and cdh2

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_571156.2 Gene:cdh2 / 30291 ZFINID:ZDB-GENE-990415-171 Length:893 Species:Danio rerio


Alignment Length:919 Identity:234/919 - (25%)
Similarity:373/919 - (40%) Gaps:193/919 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 VLTVNAKDHNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNY 119
            :|.|:..|....:.:|::  .|:..: |.: :..|.:..|..|....|....|.::|........
Zfish    50 LLKVDFVDCGRGSGLRFE--SGDPAD-FRI-DADGTVMAARTLQLTDRKGQSLEIKAKDENSQEQ 110

  Fly   120 TTVVINVRDVNDNPPV-FDRQTYRTQ------------------ITEEDDRNLPKRILQVTATDG 165
            ..|.||.......|.: |.|.:...:                  :.|...:..|:.::::   ..
Zfish   111 WMVHINFTQPKQVPVILFPRHSVLVKGDDSVNRVKRDWVIPPVNVLENSRKQFPEELVKI---QS 172

  Fly   166 DVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGE 230
            |.|:...:.|.:||.|.| .|| ...|.|:..:|.:.|.|||||:.   .|.:.....|.|..|.
Zfish   173 DKDKSNTLRYSVTGPGAD-QNP-TGLFIIDPISGLLSVTKPLDREH---IPNFHLRAHAVDINGN 232

  Fly   231 GLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIE 295
            .:....||.:|:.|:|||.|:|...|:.|.|.|....|:.|||:::.|.|||| :.|..|.|.|.
Zfish   233 QMENPIDIIINVIDMNDNRPEFTHQIWNGTVDEGAKPGTFVMTVTSQDKDDPN-TANGMLRYKIL 296

  Fly   296 KNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYS--IQVVAMDGG---GLKGTGTASIRVK 355
            ... .|...:.:|.|..:||.|.|....||||:.|.|:  ||...|:|.   ||..|.||.||:.
Zfish   297 SQT-PESPSSNMFTINNKTGKIITVAAGLDREKVPQYTLIIQATDMEGNPTYGLSNTATAVIRLL 360

  Fly   356 DLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNT----FQYKVVPNSGFGADKFA 416
            |:||..|:||::.:..||.|.....|    :..:||.|:||..|    ..|:::  ||....:|:
Zfish   361 DVNDNAPEFTRETFHGEVPENRVNVI----VTNLTVTDKDEPGTPAWNAVYRII--SGDPTGRFS 419

  Fly   417 M----VRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLR- 476
            :    |.|   .|.:.:::|:|:|   .:..|...:..:   ::.|..|..:....|...|.:| 
Zfish   420 IPTDPVTN---EGLVTVVKPVDFE---MNRSFMLTVVAD---NEVPLASGIHRTRQSTATVSIRV 475

  Fly   477 -DINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAY-KIVRSTNRKRQFAIS-D 538
             |:|:: |.||....::.:.|.....::|..|.|.|.|:.....::| |:....|   ...|. :
Zfish   476 IDVNES-PNFDPNPKQIKLEEGLPQWSMLTTFTAHDPDRYMQQTISYSKLYDPAN---WLEIDPN 536

  Fly   539 RGAVSIQRPLDRET----QDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAP-TFAQDYKP-T 597
            .|.:|....||||:    .:.::...:|.|:|.|..:.|.||.:.:.|:||||| .|.|:.:. .
Zfish   537 NGRISTIAVLDRESPYVKNNLYNATFMASDNGVPRASGTGTLQIYLLDINDNAPRVFPQEAEVCE 601

  Fly   598 LPENVSGKKILEVAAKDPDDRLRGNGGPFTFR-------------LDPLASDEIKAGFKVEYDRR 649
            .||    ...:.:.|.|.|  |..|.||:.|.             |..::.|..:...|:.|   
Zfish   602 RPE----PNAINITAVDGD--LNPNAGPYAFELPNRPSDIRRNWTLTRISGDHAQLSLKISY--- 657

  Fly   650 GDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI------GDVNDNK--MQ 706
              .|:|:                |.:||.|.|:|...|:.|:.|.:.:      ||..|.:  |.
Zfish   658 --LESGI----------------YELPISITDSGNLPMSNTTYLRIKVCQCDHHGDCVDMERIMA 704

  Fly   707 PGSKS--------------VLVYNY----QGQSQDTPIGRVYVNDPDDWDVPDK--KYYWE--VQ 749
            .|..:              |||..:    :.:.::....::.: ||:| ||.|.  ||..|  .:
Zfish   705 AGLGTGAIIAILICIIILLVLVLMFVMWMKRRDKERQAKQLLI-DPED-DVRDNILKYDEEGGGE 767

  Fly   750 EHQRFKL------DTDTGILTMRAGTRR---------GRYQLRFKVYDREHGQEDIPANLSVTVR 799
            |.|.:.|      ||....:....|.||         ..|.:|..........|.|...|.....
Zfish   768 EDQDYDLSQLQQPDTLEPDMIKPVGIRRLDERPMHSEPNYPIRSAAPHPGDIGEFIHEGLKAADT 832

  Fly   800 DITAEAVQQ------------AGSMRLSHIT------DEDFVRTWNPVKNQVEPSKLERFRNKLA 846
            |.||.....            |||:...|.:      |.|::..|.|           ||| |||
Zfish   833 DPTAPPYDSLLVFDYEGSGSTAGSLSSLHSSSSGGDQDYDYLNDWGP-----------RFR-KLA 885

  Fly   847 ELLYTDRDN 855
            : :|...|:
Zfish   886 D-MYGGNDD 893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 15/76 (20%)
Cadherin_repeat 140..248 CDD:206637 29/125 (23%)
Cadherin_repeat 256..359 CDD:206637 42/107 (39%)
Cadherin_repeat 379..481 CDD:206637 25/111 (23%)
Cadherin_repeat 489..586 CDD:206637 25/102 (25%)
Cadherin_repeat 594..703 CDD:206637 27/128 (21%)
Cadherin_repeat 724..801 CDD:206637 22/95 (23%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
cdh2NP_571156.2 Cadherin_pro 27..117 CDD:214999 14/70 (20%)
E_set 150..250 CDD:298831 29/107 (27%)
Cadherin_repeat 260..365 CDD:206637 42/106 (40%)
Cadherin_repeat 373..480 CDD:206637 27/121 (22%)
Cadherin_repeat 490..588 CDD:206637 25/100 (25%)
Cadherin 595..688 CDD:278457 26/119 (22%)
Cadherin_C 746..889 CDD:279398 39/157 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..815 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 851..872 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24027
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.010

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