DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Cdh22

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_062034.2	Gene:	Cdh22 / 29182	RGDID:	2321	Length:	813	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	167/583 - (28%)
Similarity:	274/583 - (46%)	Gaps:	84/583 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 ITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDR 209
            :.||.....|..:.::.:...:.|..|.  |.::|:|      |.:.|.|:..||||...:.|||
  Rat    68 VVEEYTGTEPLYVGKIHSDSDEGDGTIK--YTISGEG------AGTIFLIDELTGDIHATERLDR 124

  Fly   210 DQPNGRPQWRFTVFAQDEGGEGLV-GYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMT 273
            :|   :..:.....|:|.....|: ..::..:.::||||:.|:|..|.|.|:|.|....|:|||.
  Rat   125 EQ---KTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQ 186

  Fly   274 MSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVA 338
            :.|.|.|||...::|:|:||:       ..|...|.::|:||:|:|||..||||....|.:.:.|
  Rat   187 VMASDADDPTYGSSARLVYSV-------LDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQA 244

  Fly   339 MDG----GGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILT----VTVQDED 395
            .|.    |||.|:.|.:|.|.|:||.||:|.:..:...:.|:       .||.|    |..:|.|
  Rat   245 TDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQES-------APIGTAVGRVKAEDSD 302

  Fly   396 --ETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQP-LDYE----------------DPLQS 441
              |.....|.:...||.|.|.|.:..:.|...::.::|. ||:|                ||..:
  Rat   303 VGENTDMTYHLREESGSGGDAFKVTTDSDTQEAIIVVQKHLDFESQQVHTVVLEALNKFVDPRFA 367

  Fly   442 SGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQ 506
            ....||.|                   :.|.|.:.|: |..|:|......:.:.||.:||:::..
  Rat   368 DLGTFRDQ-------------------AIVRVAVTDV-DEPPEFRPPSGLLEVQEDAQVGSLVGV 412

  Fly   507 FKATDADQGGHSKVAYKIVRSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPAR 570
            ..|.|.| ..:..|.|.|.|.::.::.|.| :|.||:...:.|||||...|:|.:||::..:.|:
  Rat   413 VTARDPD-AANRPVRYAIDRDSDLEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQ 476

  Fly   571 TATATLTVIVKDVNDNAPTFAQDYKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLA 634
            .:.|:|.:.:.|||||.|..|..|:..:.|:.. |:.|..::..|.|:...|:  .|.|||.|
  Rat   477 LSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGH--RFYFRLVP-- 537

  Fly   635 SDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI 697
                :......:......:|..|:.:....|:|:.|..:.:||.:.|:|.|.::.|.|||:.|
  Rat   538 ----EEPSNPHFSLLDIEDNTAAVHTQHVGFNRQEQDVFLLPILVVDSGPPTLSSTGTLTIRI 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	25/103 (24%)
		Cadherin_repeat	256..359	CDD:206637	41/106 (39%)
		Cadherin_repeat	379..481	CDD:206637	26/124 (21%)
		Cadherin_repeat	489..586	CDD:206637	31/97 (32%)
		Cadherin_repeat	594..703	CDD:206637	27/105 (26%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh22	NP_062034.2	Cadherin_repeat	80..160	CDD:206637	21/90 (23%)
		Cadherin_repeat	169..270	CDD:206637	42/107 (39%)
		Cadherin_repeat	279..387	CDD:206637	27/134 (20%)
		Cadherin_repeat	398..492	CDD:206637	31/94 (33%)
		Cadherin_repeat	499..597	CDD:206637	27/106 (25%)
		Cadherin_C	645..804	CDD:395833
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9369
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010