Protein Alignment CadN2 and Dsc2

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_001028860.2
• Gene: Dsc2 / 291760
• RGDID: 1309426
• Length: 902
• Species: Rattus norvegicus
• Alignment Length: 725
• Identity: 186/725 - (25%)
• Similarity: 309/725 - (42%)
• Gaps: 158/725 - (21%)

  Fly     8 FWVLTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENAD----LQSTVLTVNAKDHNESTN 68
            |.|..:.:...|..|.:....::     |..:|:.|:..|..:    |:..|..:|.:.|.|
  Rat    71 FQVFEDGSVYTTNSVVLSSGQRS-----FTIWLFNTDSQEERELSVHLEGPVEVLNQRLHTE--- 127

  Fly    69 IRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNP 133
                                                     :..|..|..:..:..::.:.:..|
  Rat   128 -----------------------------------------KVLRRAKRRWAPIPCSMMENSLGP 151

  Fly   134 -PVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRT 197
             |:|.:|                       ...|..:...|.|.::|.|:|.: |. ..|.|:|.
  Rat   152 FPLFLQQ-----------------------IQSDKAQNYTIYYSISGPGVDKE-PV-GLFRIDRD 191

  Fly   198 TGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVT 262
            ||:::....:||:|.:   .:..|..|....|..:.....:.:.::|.|||.|.|.|.:|...|.
  Rat   192 TGNLYCTDRVDREQYD---SFELTALAMTPDGYMVENLLTLLIKVEDENDNYPIFTQKVYSFTVL 253

  Fly   263 ENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP-IFEIEPETGLIKTAVCCLDR 326
            ||...||.|..:.|.|.|:| ::.:.:|.|||    :|:....| :|.:.|.||:|.|....|||
  Rat   254 ENSPFGSHVGEVCATDKDEP-DTMHTRLKYSI----LEQSPSPPMLFTMHPRTGVITTTSTQLDR 313

  Fly   327 ERTPDYS--IQVVAMDGG--GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPIL 387
            |....|.  |:|..|||.  ||:.|.|..|.:.|:||..|.||:..:||.|:|..    ....:|
  Rat   314 ELIDKYQLIIKVQDMDGQYFGLQTTATCVITIGDVNDNLPTFTRTTYVTSVEENT----VNVELL 374

  Fly   388 TVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGDGT-----------GSLKIIQPLDYEDPLQS 441
            .::|||:|..|:      ||  :.|:...:..|.:|.           |.|.:|.|||||:
  Rat   375 RLSVQDKDLVNS------PN--WRANYTILKGNENGNFKIKTDPQTNEGILCVIMPLDYEE---- 427

  Fly   442 SGFRFRIQ-----VNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVG 501
               |.|:.     ||:.......|| |..::.:.|.|.::: .|..|:...:...|.|.|:..:|
  Rat   428 ---RQRVTLEIGVVNEAPYTRQAGS-KSSMSTATVTVNVKN-QDEGPECIPQTQTVRIRENVPIG 487

  Fly   502 TILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAIS-DRGAVSIQRPLDRETQ----DRHHIQIL 561
            |..:.:||.|.:......:.|:  :.::.|....:: |.|:::|.|.||||.:    ..::|.:|
  Rat   488 TRNDGYKAYDPETKNSIGIRYR--KLSDPKGWITVNEDSGSITIFRTLDREAETIRNGIYNITVL 550

  Fly   562 AID-DGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGP 625
            |:| ||   |:.|.||.::::|||||.|...   |.|:....:.....|:.|.|||:  ..||.|
  Rat   551 ALDADG---RSCTGTLGILLEDVNDNGPFIP---KQTVVICRATMSSAEIVAVDPDE--PANGPP 607

  Fly   626 FTFRLDPLASD-EIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTG 689
            |.|.|:  :|| |::..:|:  .|..|.      .:||...:..|..||.||:.:.|..  .::.
  Rat   608 FDFSLE--SSDSEVRRRWKL--TRINDT------AASLSYQNDPAFDSYVIPVRVTDRF--GLSS 660

  Fly   690 TSTLTVTIGD 699
            .::|.|.:.|
  Rat   661 VTSLNVVVCD 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	9/94 (10%)
		Cadherin_repeat	140..248	CDD:206637	20/107 (19%)
		Cadherin_repeat	256..359	CDD:206637	39/107 (36%)
		CA	388..483	CDD:214520	28/110 (25%)
		Cadherin_repeat	489..586	CDD:206637	31/102 (30%)
		Cadherin_repeat	594..703	CDD:206637	30/107 (28%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
Dsc2	NP_001028860.2	Cadherin_pro	31..111	CDD:214999	8/44 (18%)
		Cadherin	140..234	CDD:394985	22/121 (18%)
		Cadherin_repeat	247..351	CDD:206637	40/108 (37%)
		Cadherin	360..462	CDD:394985	32/121 (26%)
		Cadherin	476..568	CDD:394985	28/96 (29%)
		Cadherin_repeat	594..670	CDD:206637	26/89 (29%)
		CADH_Y-type_LIR	853..900	CDD:460041