DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and PCDHGA12

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_003726.1	Gene:	PCDHGA12 / 26025	HGNCID:	8699	Length:	932	Species:	Homo sapiens

Alignment Length:	713	Identity:	173/713 - (24%)
Similarity:	284/713 - (39%)	Gaps:	155/713 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TNIRYQI-----TGGNIGN--------------------------AFAVQNTTGVIYVASPLDYE 100
            |.|||.:     .|..:|:                          .||:...:|.:..|..:|.|
Human    29 TQIRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDRE 93

  Fly   101 T----RPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVT 161
            .    ..:.:|.|:.....|.....|.:.|||:|||.|.|.......:|:|.            .
Human    94 ELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKISEN------------A 146

  Fly   162 ATDGDVDRPINIVYFLTGQGIDPDNPANS--KFDINRTT---------------GDIFVLKPLDR 209
            ||:         :.|......|||...||  .::::..|               .::.:.:.|||
Human   147 ATE---------MRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVLKRALDR 202

  Fly   210 DQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTM 274
            ::   :......:.|.|.|.....|.|.|:|.:.|.|||||.|.|..|..:|.||...|:.::.:
Human   203 EE---KAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVV 264

  Fly   275 SAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAM 339
            :|.   ||:|..||::.||..   ..::..|.:|:::..:|.|.| :..||.|.:..|.::|.||
Human   265 NAT---DPDEGVNAEVRYSFR---YVDDKAAQVFKLDCNSGTIST-IGELDHEESGFYQMEVQAM 322

  Fly   340 DGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETN--GTYIPETPILTVTVQDEDETNTFQY 402
            |..|........|.|.|:||..|:.......:.|.|.:  ||.|   .:|.|..||.:|......
Human   323 DNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI---ALLNVNDQDSEENGQVIC 384

  Fly   403 KVVPNSGFGADK-----FAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSD 462
            .:..|..|..:|     :::|.:        |:  ||.|   |...:...:...|:|.  |..|.
Human   385 FIQGNLPFKLEKSYGNYYSLVTD--------IV--LDRE---QVPSYNITVTATDRGT--PPLST 434

  Fly   463 KYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRS 527
            :.|::     :.:.|.|||.|.|.:......|.|:...|..|....|.|.|...::::.|.:..:
Human   435 ETHIS-----LNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAEN 494

  Fly   528 TNRKRQFAI-----SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNA 587
            |.:....:.     ||.|.:......|.|......::::|.|:|.|..::..:|::.|.|.||||
Human   495 TIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNA 559

  Fly   588 PTFAQDYKPTLPENVS------------GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKA 640
            |....   |.||.:.|            |..:.:|.|.|.|.   |.....::||       :||
Human   560 PEILY---PALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDS---GQNAWLSYRL-------LKA 611

  Fly   641 G----FKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGD 699
            .    |.|.. ..|:.....|::      ||:|.|. ::.:.::|:|.|.::.|.||||.:.|
Human   612 SEPGLFSVGL-HTGEVRTARALL------DRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	20/99 (20%)
		Cadherin_repeat	140..248	CDD:206637	23/124 (19%)
		Cadherin_repeat	256..359	CDD:206637	30/102 (29%)
		Cadherin_repeat	379..481	CDD:206637	23/106 (22%)
		Cadherin_repeat	489..586	CDD:206637	22/101 (22%)
		Cadherin_repeat	594..703	CDD:206637	31/122 (25%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDHGA12	NP_003726.1	Cadherin_2	30..112	CDD:285466	13/81 (16%)
		Cadherin_repeat	137..238	CDD:206637	23/124 (19%)
		Cadherin_repeat	246..343	CDD:206637	31/103 (30%)
		Cadherin_repeat	355..448	CDD:206637	26/115 (23%)
		Cadherin_repeat	456..558	CDD:206637	22/101 (22%)
		Cadherin_repeat	579..666	CDD:206637	26/104 (25%)
		Cadherin_C_2	688..772	CDD:293101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	803..841
		Cadherin_tail	809..>905	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	902..932
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000