Protein Alignment CadN2 and Cdh20

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_035930.1
• Gene: Cdh20 / 23836
• MGIID: 1346069
• Length: 801
• Species: Mus musculus
• Alignment Length: 892
• Identity: 224/892 - (25%)
• Similarity: 371/892 - (41%)
• Gaps: 221/892 - (24%)

  Fly    74 TGGNIGNA------------FAVQNTTGVIYVASPL-DYETRPRYELRLEATRNRKNNYTTVVIN 125
            |.|.:.||            :|:.:.|..:..::|: :.|....:..|.::.:..|.::
Mouse     3 TTGRMSNAKSWLGLGTSLYFWALMDLTATVLSSTPMPEVELETLFSGRSQSHQRSKRSW------ 61

  Fly   126 VRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDR-PINIVYFLTGQGIDPDNPAN 189
                     |:::.....:.|..|.       |.|.....|:|| ..:|.|.|:|:|      |.
Mouse    62 ---------VWNQFFVLEEYTGTDP-------LYVGKLHSDMDRGDGSIKYILSGEG------AG 104

  Fly   190 SKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQD-EGGEGLVGYADIQVNLKDINDNAPQFP 253
            ..|.|:.|||||..::.|||::   |.|:.....|.| ..|..:...::..:.::|||||.|:|.
Mouse   105 IVFTIDDTTGDIHAIQRLDREE---RAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFL 166

  Fly   254 QGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIK 318
            .|.|...|.|....|:||:.::|.|.|||....:|:::|||.:       |.|.|.::.:||:|:
Mouse   167 DGPYIATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQ-------GQPYFSVDSKTGVIR 224

  Fly   319 TAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGT 379
            ||:..:|||....|.:.:.|.|.    |||.||.|.:|.:.|:||.||:|.:..:...|.|:
Mouse   225 TALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLES--- 286

  Fly   380 YIPETPILT----VTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD---GTGSLKIIQPLDYED 437
                .||.:    |..:|.||....:.|.....|.|||.|.:  |.|   ..|.:.:.:||.:|
Mouse   287 ----APISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDI--NTDQNFQVGIITVKKPLSFE- 344

  Fly   438 PLQSSGFRFRIQVNDKGDDGPGGSDKYHVAY---------SWVVVKLRDINDNVPKFDREHIEVS 493
              ....:..:::         |.:....:.:         :.|.:.:.|: |..|.|:.....|.
Mouse   345 --SKKSYTLKVE---------GSNPHLEMRFLNLGPFQDTTTVHISVEDV-DEPPVFEPGFYFVE 397

  Fly   494 IYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAIS-DRGAVSIQRPLDRETQDRHH 557
            :.||..:||.::...|.|.|...:| :.|.|.|.::..|.|.:. ..||:...||||||....|:
Mouse   398 VPEDVTIGTTIQIISAKDPDVTNNS-IRYSIDRGSDPGRFFYVDITTGALMTARPLDREEFSWHN 461

  Fly   558 IQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENV-SGKKILEVAAKDPDDRLRG 621
            |.:||::..:|::..:..:|:.|.|||||||.|.:.|:..:.||. :|:.|..|:|.|.||  ..
Mouse   462 ITVLAMEMNNPSQVGSVAVTIKVLDVNDNAPEFPRFYEAFICENAKAGQLIQTVSAVDQDD--PH 524

  Fly   622 NGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPA 686
            ||..|.:.|.|.|::  ...|.|    |.:.:|...|::....|.::.|..:.:||.|.|:|.|.
Mouse   525 NGQHFYYSLAPEAAN--NPNFTV----RDNQDNTARILTRRSGFRQQEQSVFYLPILIADSGQPV 583

  Fly   687 MTGTSTLTVTIGDVNDN----------KMQPGSKS-----------------VLVYNYQGQSQDT 724
            ::.|.|||:.:...||:          .:.|.|.|                 ||:.....:.:..
Mouse   584 LSSTGTLTIQVCSCNDDGHVMSCSPEAYLLPVSLSRGALIAILACIFVLLVLVLLILSMRRHRKQ 648

  Fly   725 PIGRVYVNDPD------------------DWDVPDKKYYW-------------------EVQEHQ 752
            |    |:.|.|                  |.:..|....|                   |::...
Mouse   649 P----YIIDDDENIHENIVRYDDEGGGEEDTEAFDIAAMWNPREAQAGAAPKTRQDMLPEIESLS 709

  Fly   753 RFKLDTDTGILTMRAGTRRGRYQLRFKVYDRE----------------HGQEDIPANLSVTVRDI 801
            |:...|.....|:.:      |.|. |:|:.:                .|...:..:|| :::..
Mouse   710 RYVPQTCAVSSTVHS------YVLA-KLYEADMDLWAPPFDSLQTYMFEGDGSVAGSLS-SLQSA 766

  Fly   802 TAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAEL 848
            |:::.|..           ||:..|.|           ||| |||||
Mouse   767 TSDSEQSF-----------DFLTDWGP-----------RFR-KLAEL 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	10/70 (14%)
		Cadherin_repeat	140..248	CDD:206637	31/109 (28%)
		Cadherin_repeat	256..359	CDD:206637	37/106 (35%)
		CA	388..483	CDD:214520	20/110 (18%)
		Cadherin_repeat	489..586	CDD:206637	32/97 (33%)
		Cadherin_repeat	594..703	CDD:206637	34/109 (31%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
Cdh20	NP_035930.1	CA	85..163	CDD:214520	29/86 (34%)
		Cadherin_repeat	169..270	CDD:206637	38/107 (36%)
		Cadherin_repeat	278..385	CDD:206637	23/128 (18%)
		Cadherin_repeat	394..490	CDD:206637	32/96 (33%)
		Cadherin_repeat	498..599	CDD:206637	33/108 (31%)
		CADH_Y-type_LIR	733..792	CDD:460041	17/82 (21%)