DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and Dchs1

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_006507718.1	Gene:	Dchs1 / 233651	MGIID:	2685011	Length:	3431	Species:	Mus musculus

Alignment Length:	827	Identity:	227/827 - (27%)
Similarity:	375/827 - (45%)	Gaps:	112/827 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 IADKNDSPPYFDRFLYETE-IDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNAFAVQNT 87
            :.|.||:.|.|||.||..| :.|.|...|.|:.|.|:|.::.||  |.|.:..|...:.|::..|
Mouse   596 VTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQITYSLAPGTHTHWFSIDPT 660

  Fly    88 TGVIYVASPLDYETRPRYELRLEATRNRKN---NYTTVVINVRDVNDNPPVFDRQTYRTQITEED 149
            :|:|..|:.||||..|:.:|.:.||.....   :..||.:.::|||||.|.|.|..|...:.|..
Mouse   661 SGIITTAATLDYELEPQPQLIVVATDGGLPPLVSSATVSVALQDVNDNEPQFQRTFYNASLPEGT 725

  Fly   150 DRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNG 214
            ...  ...|||||||.| ..|..::.:..|.|:...  .:..|.|:..:||:...:.|||||  |
Mouse   726 QPG--TCFLQVTATDAD-SGPFGLLSYSLGAGLGAS--GSPPFRIDAHSGDVCTTRTLDRDQ--G 783

  Fly   215 RPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDY 279
            ...:.|||.|.|  |.||.....::|.:.|.|||.|||....|..:::...|.|::|:.:.|
Mouse   784 PSSFDFTVTAID--GGGLKSMVYVKVFVADENDNPPQFYPREYAASLSAQSTPGTAVLRVHA--- 843

  Fly   280 DDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGL 344
            .||::..:.:|.|.|...     ...|:|.::..:||: |....|.|.......:::.|.|||||
Mouse   844 HDPDQGPHGRLSYHILAG-----NSPPLFALDAHSGLL-TVAWPLGRRANSVVQLEIGAQDGGGL 902

  Fly   345 KGTGTASIRVKDL--NDMPPQFTKDEWVTEVDETNGTYIPETPI--------------LTVTVQD 393
            :....|.:.:..:  ...||.|.:.::|..|.|   ...|.|.:              :|:|:..
Mouse   903 QAEPIARVNISIVPGTPTPPIFEQLQYVFSVPE---DVAPGTSVGIIQAHNPPGRLGPVTLTLSG 964

  Fly   394 EDETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGP 458
            .|          |...|..|        ..:|.||.::|||.|  |........::.      |.
Mouse   965 GD----------PRGLFSLD--------SPSGLLKTLRPLDRE--LLGPVLELEVRA------GS 1003

  Fly   459 GGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYK 523
            |....:.||.  :.|.|.|:|||.|.|......|.:.::|..||.:...:|.|.|.|.:|::.:.
Mouse  1004 GTPPVFAVAR--IRVLLDDVNDNSPAFPAPEDTVLLPQNTAPGTPIYTLRALDPDSGANSRITFN 1066

  Fly   524 IVRSTNRKRQFAIS-DRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKD--VND 585
            ::...:  ..|.:. ..|.|.:..||.......|.:::.|.|.|||.||:...|.|:::|  ::.
Mouse  1067 LLAGGD--GLFTVDPTTGHVRLMGPLGPPGGPAHELEVEARDGGSPPRTSHFRLRVVIQDLGIHG 1129

  Fly   586 NAPTF-AQDYKPTLPE-NVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDR 648
            .||.| :..|:..||. ..:|.:||:|.|:.||      |.|.|:.   ||:|...:.|.:|
Mouse  1130 LAPRFDSPTYRVDLPSGTTTGTQILQVQAQAPD------GSPVTYH---LAADGASSPFGLE--- 1182

  Fly   649 RGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPA----MTGTSTLTVTIGDVNDNKMQPGS 709
               :::|...:.:  ..|||:|:.|.:.: :..:|:.|    .|||:|:.|.|.:.||:..:...
Mouse  1183 ---SQSGWLWVRT--ALDRESQELYTLKV-MAVSGSKAELGQQTGTATVRVIILNQNDHSPRLSE 1241

  Fly   710 KSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQ----EHQRFKLDTDTG-ILTMRAGT 769
            :...:...:.|...|.:|||:..|.|..  |:.:..:.:|    :.:.|::...|| :.|::...
Mouse  1242 EPTFLAVAENQPPGTSVGRVFATDRDSG--PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD 1304

  Fly   770 R--RGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEA---VQQAGS 811
            |  :..:||..:|.|...........:.|.|.|:...:   :|.:|:
Mouse  1305 REQQSSFQLLVQVQDGGSPPRSATGTVHVAVLDLNDNSPTFLQASGA 1351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	32/96 (33%)
		Cadherin_repeat	140..248	CDD:206637	34/107 (32%)
		Cadherin_repeat	256..359	CDD:206637	24/104 (23%)
		Cadherin_repeat	379..481	CDD:206637	24/115 (21%)
		Cadherin_repeat	489..586	CDD:206637	25/99 (25%)
		Cadherin_repeat	594..703	CDD:206637	33/113 (29%)
		Cadherin_repeat	724..801	CDD:206637	19/83 (23%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Dchs1	XP_006507718.1	Cadherin_repeat	183..273	CDD:206637
		Cadherin_repeat	284..385	CDD:206637
		Cadherin_repeat	394..492	CDD:206637
		Cadherin_repeat	508..602	CDD:206637	2/5 (40%)
		Cadherin_repeat	616..708	CDD:206637	30/91 (33%)
		Cadherin_repeat	717..815	CDD:206637	34/106 (32%)
		Cadherin_repeat	823..915	CDD:206637	24/100 (24%)
		Cadherin_repeat	928..1024	CDD:206637	27/126 (21%)
		Cadherin_repeat	1034..1124	CDD:206637	24/91 (26%)
		Cadherin_repeat	1138..1235	CDD:206637	33/114 (29%)
		Cadherin_repeat	1248..1341	CDD:206637	21/94 (22%)
		Cadherin_repeat	1358..1446	CDD:206637
		Cadherin_repeat	1469..1565	CDD:206637
		Cadherin_repeat	1578..1675	CDD:206637
		Cadherin_repeat	1684..1777	CDD:206637
		Cadherin_repeat	1786..1880	CDD:206637
		Cadherin_repeat	1890..1984	CDD:206637
		Cadherin_repeat	1992..2089	CDD:206637
		Cadherin_repeat	2116..2192	CDD:206637
		Cadherin_repeat	2207..2300	CDD:206637
		Cadherin_repeat	2308..2406	CDD:206637
		Cadherin_repeat	2415..2505	CDD:206637
		Cadherin_repeat	2514..2611	CDD:206637
		Cadherin_repeat	2619..2731	CDD:206637
		Cadherin_repeat	2739..2835	CDD:206637
		Cadherin_repeat	2845..2941	CDD:206637
		Cadherin_repeat	2950..3056	CDD:206637
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9B2
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100175
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710