DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and Cdh23

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:XP_017169419.1 Gene:Cdh23 / 22295 MGIID:1890219 Length:3361 Species:Mus musculus


Alignment Length:2009 Identity:444/2009 - (22%)
Similarity:722/2009 - (35%) Gaps:546/2009 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNEST--NIRYQITGGNIGNAFAV 84
            |:|.:.::||:.|.|.:.||...:.||..:.::||||.|.|::..|  .:.|..:  :..:.|::
Mouse   453 VKITLINENDNRPIFSQPLYNVSLYENITVGTSVLTVLATDNDVGTFGEVNYFFS--DDPDRFSL 515

  Fly    85 QNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTT--VVINVRDVNDNPPVFDRQTYRTQITE 147
            ...||:|.:.:.||||...|:.|.:.| |:.....||  |.|||.|||||.|.|.:..|...:.|
Mouse   516 DKDTGLIMLIARLDYELIQRFTLTVIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRE 579

  Fly   148 EDDRNLPK--RILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDIN--RTTGDIFVLKPLD 208
                |.|.  :::::.|||.| ..|.|::.:    .|...:...|.|||:  ...|.|.|.:|||
Mouse   580 ----NEPSVTQLVRLRATDED-SPPNNLITY----SIVNASAFGSYFDISIYEGYGVISVSRPLD 635

  Fly   209 RDQ-PNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVM 272
            .:| |||...  .||.|:|.|...|.....:.:.:.|.|||.|.|.:..||.:|.||..||::|:
Mouse   636 YEQIPNGLIY--LTVMAKDAGNPPLYSTVPVTIEVFDENDNPPTFSKPAYFVSVLENIMAGATVL 698

  Fly   273 TMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVV 337
            .::|.|.|...|.....:|||:|        |:..|.|...:|.| |....||||...:|.:.|.
Mouse   699 FLNATDLDRSREYGQESIIYSLE--------GSSQFRINARSGEI-TTTSLLDRETKSEYILIVR 754

  Fly   338 AMDGG----GLKGTGTASIRVKDLNDMPPQFTKDE--WVTEVDETNGTYIPETPILTVTVQDED- 395
            |:|||    ...|..|.::.:.|:||..|.: ||.  ::..|:.|.    |::.:.||...|.| 
Mouse   755 AVDGGVGHNQKTGIATVNVTLLDINDNHPTW-KDAPYYINLVEMTP----PDSDVTTVVAVDPDL 814

  Fly   396 -ETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQ-PLDYE--DPLQSSGFR-FRIQVNDKGD 455
             |..|..|.:.|     .:||..:.:  .||.::... .||.|  ||:::...| ..:.|.|.|.
Mouse   815 GENGTLVYSIHP-----PNKFYSLNS--TTGKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCGR 872

  Fly   456 DGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKV 520
            .....:..     :.|.|.|.|:|||.|.|........|.|.|..|..:.|..|.|.|:|.:..|
Mouse   873 PPLKATSS-----ATVFVNLLDLNDNDPTFRNLPFVAEILEGTPAGVSVYQVVAIDLDEGLNGLV 932

  Fly   521 AYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVND 585
            :|::.....|......|..|.|:....||||....:.::::|.|.|:|.:::|:||||.|.||||
Mouse   933 SYRMQVGMPRMDFVINSTSGVVTTTAELDRERIAEYQLRVVASDAGTPTKSSTSTLTVRVLDVND 997

  Fly   586 NAPT-FAQDYKPTLPENVSGK-KILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDR 648
            ..|| |...|..::.|:|..: :::.:...|.|..|......|      :.:..:...|.|.|..
Mouse   998 ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYF------ITAGNVDGKFSVGYRD 1056

  Fly   649 RGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNG--APAMTGTSTLTVTIGDVNDNKMQPGSKS 711
                    |::.::...|||...:|.:.:|..|||  ....|||:|:.||:.|||||:     ..
Mouse  1057 --------AVVRTVVGLDRETTAAYTLVLEAIDNGPVGKRRTGTATVFVTVLDVNDNR-----PI 1108

  Fly   712 VLVYNYQGQ-SQDTPIGRVYV----NDPDDWDVPDKKYYWEVQEH-QRFKLDTDTGILTMRA--- 767
            .|..:|:.. .:|.|.|...|    .|.|:.:.....|......| ..|::...:|:| ||.   
Mouse  1109 FLQSSYEASVPEDIPEGHSIVQLKATDADEGEFGRVWYRILHGNHGNNFRIHVGSGLL-MRGPRP 1172

  Fly   768 --GTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVK 830
              ..|...:.|..:.|:.:.|.......:.|.|.|:..||                      ||.
Mouse  1173 LDRERNSSHVLMVEAYNHDLGPMRSSVRVIVYVEDVNDEA----------------------PVF 1215

  Fly   831 NQVEPSKL-----ERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAV 890
            .|.:.::|     ......:..:..||:|..|        |..     |::...|..:..:    
Mouse  1216 TQQQYNRLGLRETAGIGTSVIVVRATDKDTGD--------GGL-----VNYRILSGAEGKF---- 1263

  Fly   891 RLNGVVQMHREEIEKDVGLNIT------------MVNINECLHEG-----KGKCG-----SNSCT 933
                       ||::..||.:|            ::|::..  :|     :|.|.     .|...
Mouse  1264 -----------EIDESTGLIVTVDYLDYETKTSYLMNVSAT--DGAPPFNQGFCSVYVTLLNELD 1315

  Fly   934 SKVELGKKPYTVSVNRTALVGVRL-DISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPKC 997
            ..|:.....|...:.....:|..: .:.|..:......|::                        
Mouse  1316 EAVQFSNASYEAVIMENLALGTEIVRVQAYSIDNLNQITYR------------------------ 1356

  Fly   998 VACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRV--ADGLI------LYNGPI 1054
                  ::.....|:...|:                   ::.||.|  ..||:      .|...:
Mouse  1357 ------FDAYTSAQAKALFK-------------------IDAITGVITVKGLVDREKGDFYTLTV 1396

  Fly  1055 VP----PKPEETVISDFIALELEQGYPRLLIDFGSGT---------LELRVKTKKTLD------- 1099
            |.    ||.:.||......|:.....||  .||.|.:         :..||.|.|..|       
Mouse  1397 VADDGGPKVDSTVKVYITVLDENDNSPR--FDFTSDSAISVPEDCPVGQRVATVKARDPDAGSNG 1459

  Fly  1100 --------DGVWHRLDIFWDTENVRMVVDFCRTALVSEMED-----------GTPPEFDDNACQA 1145
                    ..:....:|....:::..|  |....|..|..|           ||||...|:..|.
Mouse  1460 QVVFSLASGNIAGAFEIITSNDSIGEV--FVAKPLDREELDHYILKVVASDRGTPPRKKDHILQV 1522

  Fly  1146 R----GQIPPFAES---LNLNQPLQLGG----LYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNS 1199
            .    ...||..||   .|::....:||    :..:..|:.:          |.:..:...|...
Mouse  1523 TILDVNDNPPVIESPFGYNVSVNENVGGGTSVVQVRATDRDI----------GINSVLSYYITEG 1577

  Fly  1200 EHYDLAFPALARNS-----FPACPQTDE-------VCLKTEHTARCWEHGNCVASLVQAKCHCQP 1252
            .. |:.| .:.|.|     .||.|..:.       |.::.|.|           ..:.|..|...
Mouse  1578 NE-DMTF-RMDRISGEIATRPAPPDRERQNFYHLVVTVEDEGT-----------PTLSATTHVYV 1629

  Fly  1253 GWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQL-QLRFRTREQG--GELFRVSDQHHREYA 1314
            ..:....|.|..     .|.:.:..|...||..:|.| .::....::|  |.:         .||
Mouse  1630 TIVDENDNAPVF-----QQPHYEVVLDEGPDTINTSLITVQALDLDEGPNGTV---------TYA 1680

  Fly  1315 ILELRRGHLQFRYNLNSMRNEEQLLTLTA-----IAVNDGQWHVI------------RISRYGSA 1362
            |:   .|::     :|:.|..:....:||     ..::.|::.:|            |::...:.
Mouse  1681 IV---AGNI-----INTFRINKHTGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1737

  Fly  1363 ALMELDGGES-----RRYNESFHFTGHQ-----W--LTIDKQEGVYAGGKAEYTGIKTFEVQSDF 1415
            .:...|..::     |.|...|..|..|     |  |..|:..|  ..|:.||: :...:...:|
Mouse  1738 LVNVNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTFLAHDRDSG--PNGQVEYS-VVDGDPLGEF 1799

  Fly  1416 QRSCLD-------DIRLDGKHLP------------LPPAMNGTQWG--------QATMARNLERN 1453
            ..|.::       |:.||.:.:.            :||..:....|        ...:..||..|
Mouse  1800 VISPVEGVLRVRKDVELDRETIAFYNLTICARDRGVPPLSSTMLVGIRVLDINDNDPVLLNLPMN 1864

  Fly  1454 --CPSNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDT-KGC----------VDRNECLDLP 1505
              ...|.|.|:.:                    ..:::||. .||          .:|.....:.
Mouse  1865 VTISENSPVSSFV--------------------AHVLASDADSGCNALLTFNITAGNRERAFFIN 1909

  Fly  1506 CLNGATCINLEPRLRYRCICPEGYWGENCELVQEGQRLKLSMGALGAIFVCLIIILILALIFVLY 1570
            ...|...:| .|..|.|  .||             .||.:|:                       
Mouse  1910 ATTGIVTVN-RPLDRER--IPE-------------YRLTVSV----------------------- 1935

  Fly  1571 SRKRKTTKKKKRSGPE------KDVRETVISYEDEGG-------GEDDMTAFDITPLQIPISAQG 1622
                       :..||      ||....::|..||..       |.......:.:|...|::...
Mouse  1936 -----------KDNPENPRIARKDFDLLLVSLADENDNHPLFTEGTYQAEVMENSPAGTPLTVLN 1989

  Fly  1623 GPPDIAACKMPIIYPVMT--LLPPGQEL----NVAYLMEERKQ-RIDKDNNAPPFDDLRNFTFEG 1680
            | |.:|......:|.|:|  ||....:|    |...::..|.. .||::..:|||.:|.      
Mouse  1990 G-PILALDADEDVYAVVTYQLLGTHSDLFVIDNSTGVVTVRSGIIIDREAFSPPFLELL------ 2047

  Fly  1681 SGSIAESLSSLASGTD-------DENQDF----------NYLQNWGPRFNALAAMYVHDKAKASS 1728
              .:||.:..| :||.       |:|.::          :.|:|..|.|:.|......:.:..:.
Mouse  2048 --LLAEDIGQL-NGTAHLFITILDDNDNWPTFSPPTYTVHLLENCPPGFSVLQVTATDEDSGLNG 2109

  Fly  1729 QLPSDGGGGSGDGPGPGASSSSPLGGGGTGGGSGIPGNV-----LAVVATGSGAGPGGG 1782
            :|......|:.|     .....|:.|....|.:.|....     |.||||..|..|..|
Mouse  2110 ELVYRIEAGAQD-----RFLIHPVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSG 2163

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637 32/94 (34%)
Cadherin_repeat 140..248 CDD:206637 33/112 (29%)
Cadherin_repeat 256..359 CDD:206637 35/106 (33%)
CA 388..483 CDD:214520 28/100 (28%)
Cadherin_repeat 489..586 CDD:206637 32/96 (33%)
Cadherin_repeat 594..703 CDD:206637 28/111 (25%)
EGF_CA 977..1010 CDD:238011 0/32 (0%)
LamG 1013..1198 CDD:238058 45/242 (19%)
EGF_2 1233..1259 CDD:400365 2/25 (8%)
LamG 1265..1426 CDD:238058 35/199 (18%)
EGF_CA 1497..1535 CDD:238011 8/37 (22%)
CADH_Y-type_LIR 1662..1719 CDD:460041 17/73 (23%)
Cdh23XP_017169419.1 Cadherin_repeat 51..137 CDD:206637
Cadherin_repeat 145..240 CDD:206637
Cadherin_repeat 249..353 CDD:206637
Cadherin_repeat 361..463 CDD:206637 3/9 (33%)
Cadherin_repeat 472..564 CDD:206637 32/94 (34%)
Cadherin_repeat 573..674 CDD:206637 33/111 (30%)
Cadherin_repeat 683..781 CDD:206637 36/106 (34%)
Cadherin_repeat 789..893 CDD:206637 29/119 (24%)
Cadherin_repeat 901..997 CDD:206637 31/95 (33%)
Cadherin_repeat 1006..1105 CDD:206637 28/112 (25%)
Cadherin_repeat 1113..1210 CDD:206637 21/97 (22%)
Cadherin_repeat 1225..1315 CDD:206637 17/119 (14%)
Cadherin_repeat 1324..1421 CDD:206637 18/145 (12%)
Cadherin_repeat 1433..1530 CDD:206637 17/98 (17%)
Cadherin_repeat 1540..1637 CDD:206637 18/119 (15%)
Cadherin_repeat 1645..1747 CDD:206637 19/118 (16%)
Cadherin_repeat 1759..1854 CDD:206637 18/97 (19%)
Cadherin_repeat 1862..1962 CDD:206637 26/169 (15%)
Cadherin_repeat 1970..2072 CDD:206637 26/111 (23%)
Cadherin_repeat 2080..2176 CDD:206637 20/89 (22%)
Cadherin_repeat 2187..2296 CDD:206637
Cadherin_repeat 2308..2405 CDD:206637
Cadherin_repeat 2413..2511 CDD:206637
Cadherin_repeat 2520..2614 CDD:206637
Cadherin_repeat 2627..2725 CDD:206637
Cadherin_repeat 2742..2848 CDD:206637
Cadherin_repeat 2857..2958 CDD:206637
Blue background indicates that the domain is not in the aligned region.

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