DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and Cdh23

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:XP_017169419.1 Gene:Cdh23 / 22295 MGIID:1890219 Length:3361 Species:Mus musculus


Alignment Length:2009 Identity:444/2009 - (22%)
Similarity:722/2009 - (35%) Gaps:546/2009 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNEST--NIRYQITGGNIGNAFAV 84
            |:|.:.::||:.|.|.:.||...:.||..:.::||||.|.|::..|  .:.|..:  :..:.|::
Mouse   453 VKITLINENDNRPIFSQPLYNVSLYENITVGTSVLTVLATDNDVGTFGEVNYFFS--DDPDRFSL 515

  Fly    85 QNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTT--VVINVRDVNDNPPVFDRQTYRTQITE 147
            ...||:|.:.:.||||...|:.|.:.| |:.....||  |.|||.|||||.|.|.:..|...:.|
Mouse   516 DKDTGLIMLIARLDYELIQRFTLTVIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRE 579

  Fly   148 EDDRNLPK--RILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDIN--RTTGDIFVLKPLD 208
                |.|.  :::::.|||.| ..|.|::.:    .|...:...|.|||:  ...|.|.|.:|||
Mouse   580 ----NEPSVTQLVRLRATDED-SPPNNLITY----SIVNASAFGSYFDISIYEGYGVISVSRPLD 635

  Fly   209 RDQ-PNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVM 272
            .:| |||...  .||.|:|.|...|.....:.:.:.|.|||.|.|.:..||.:|.||..||::|:
Mouse   636 YEQIPNGLIY--LTVMAKDAGNPPLYSTVPVTIEVFDENDNPPTFSKPAYFVSVLENIMAGATVL 698

  Fly   273 TMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVV 337
            .::|.|.|...|.....:|||:|        |:..|.|...:|.| |....||||...:|.:.|.
Mouse   699 FLNATDLDRSREYGQESIIYSLE--------GSSQFRINARSGEI-TTTSLLDRETKSEYILIVR 754

  Fly   338 AMDGG----GLKGTGTASIRVKDLNDMPPQFTKDE--WVTEVDETNGTYIPETPILTVTVQDED- 395
            |:|||    ...|..|.::.:.|:||..|.: ||.  ::..|:.|.    |::.:.||...|.| 
Mouse   755 AVDGGVGHNQKTGIATVNVTLLDINDNHPTW-KDAPYYINLVEMTP----PDSDVTTVVAVDPDL 814

  Fly   396 -ETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQ-PLDYE--DPLQSSGFR-FRIQVNDKGD 455
             |..|..|.:.|     .:||..:.:  .||.::... .||.|  ||:::...| ..:.|.|.|.
Mouse   815 GENGTLVYSIHP-----PNKFYSLNS--TTGKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCGR 872

  Fly   456 DGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKV 520
            .....:..     :.|.|.|.|:|||.|.|........|.|.|..|..:.|..|.|.|:|.:..|
Mouse   873 PPLKATSS-----ATVFVNLLDLNDNDPTFRNLPFVAEILEGTPAGVSVYQVVAIDLDEGLNGLV 932

  Fly   521 AYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVND 585
            :|::.....|......|..|.|:....||||....:.::::|.|.|:|.:::|:||||.|.||||
Mouse   933 SYRMQVGMPRMDFVINSTSGVVTTTAELDRERIAEYQLRVVASDAGTPTKSSTSTLTVRVLDVND 997

  Fly   586 NAPT-FAQDYKPTLPENVSGK-KILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDR 648
            ..|| |...|..::.|:|..: :::.:...|.|..|......|      :.:..:...|.|.|..
Mouse   998 ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYF------ITAGNVDGKFSVGYRD 1056

  Fly   649 RGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNG--APAMTGTSTLTVTIGDVNDNKMQPGSKS 711
                    |::.::...|||...:|.:.:|..|||  ....|||:|:.||:.|||||:     ..
Mouse  1057 --------AVVRTVVGLDRETTAAYTLVLEAIDNGPVGKRRTGTATVFVTVLDVNDNR-----PI 1108

  Fly   712 VLVYNYQGQ-SQDTPIGRVYV----NDPDDWDVPDKKYYWEVQEH-QRFKLDTDTGILTMRA--- 767
            .|..:|:.. .:|.|.|...|    .|.|:.:.....|......| ..|::...:|:| ||.   
Mouse  1109 FLQSSYEASVPEDIPEGHSIVQLKATDADEGEFGRVWYRILHGNHGNNFRIHVGSGLL-MRGPRP 1172

  Fly   768 --GTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVK 830
              ..|...:.|..:.|:.:.|.......:.|.|.|:..||                      ||.
Mouse  1173 LDRERNSSHVLMVEAYNHDLGPMRSSVRVIVYVEDVNDEA----------------------PVF 1215

  Fly   831 NQVEPSKL-----ERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAV 890
            .|.:.::|     ......:..:..||:|..|        |..     |::...|..:..:    
Mouse  1216 TQQQYNRLGLRETAGIGTSVIVVRATDKDTGD--------GGL-----VNYRILSGAEGKF---- 1263

  Fly   891 RLNGVVQMHREEIEKDVGLNIT------------MVNINECLHEG-----KGKCG-----SNSCT 933
                       ||::..||.:|            ::|::..  :|     :|.|.     .|...
Mouse  1264 -----------EIDESTGLIVTVDYLDYETKTSYLMNVSAT--DGAPPFNQGFCSVYVTLLNELD 1315

  Fly   934 SKVELGKKPYTVSVNRTALVGVRL-DISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPKC 997
            ..|:.....|...:.....:|..: .:.|..:......|::                        
Mouse  1316 EAVQFSNASYEAVIMENLALGTEIVRVQAYSIDNLNQITYR------------------------ 1356

  Fly   998 VACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRV--ADGLI------LYNGPI 1054
                  ::.....|:...|:                   ::.||.|  ..||:      .|...:
Mouse  1357 ------FDAYTSAQAKALFK-------------------IDAITGVITVKGLVDREKGDFYTLTV 1396

  Fly  1055 VP----PKPEETVISDFIALELEQGYPRLLIDFGSGT---------LELRVKTKKTLD------- 1099
            |.    ||.:.||......|:.....||  .||.|.:         :..||.|.|..|       
Mouse  1397 VADDGGPKVDSTVKVYITVLDENDNSPR--FDFTSDSAISVPEDCPVGQRVATVKARDPDAGSNG 1459

  Fly  1100 --------DGVWHRLDIFWDTENVRMVVDFCRTALVSEMED-----------GTPPEFDDNACQA 1145
                    ..:....:|....:::..|  |....|..|..|           ||||...|:..|.
Mouse  1460 QVVFSLASGNIAGAFEIITSNDSIGEV--FVAKPLDREELDHYILKVVASDRGTPPRKKDHILQV 1522

  Fly  1146 R----GQIPPFAES---LNLNQPLQLGG----LYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNS 1199
            .    ...||..||   .|::....:||    :..:..|:.:          |.:..:...|...
Mouse  1523 TILDVNDNPPVIESPFGYNVSVNENVGGGTSVVQVRATDRDI----------GINSVLSYYITEG 1577

  Fly  1200 EHYDLAFPALARNS-----FPACPQTDE-------VCLKTEHTARCWEHGNCVASLVQAKCHCQP 1252
            .. |:.| .:.|.|     .||.|..:.       |.::.|.|           ..:.|..|...
Mouse  1578 NE-DMTF-RMDRISGEIATRPAPPDRERQNFYHLVVTVEDEGT-----------PTLSATTHVYV 1629

  Fly  1253 GWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQL-QLRFRTREQG--GELFRVSDQHHREYA 1314
            ..:....|.|..     .|.:.:..|...||..:|.| .::....::|  |.:         .||
Mouse  1630 TIVDENDNAPVF-----QQPHYEVVLDEGPDTINTSLITVQALDLDEGPNGTV---------TYA 1680

  Fly  1315 ILELRRGHLQFRYNLNSMRNEEQLLTLTA-----IAVNDGQWHVI------------RISRYGSA 1362
            |:   .|::     :|:.|..:....:||     ..::.|::.:|            |::...:.
Mouse  1681 IV---AGNI-----INTFRINKHTGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1737

  Fly  1363 ALMELDGGES-----RRYNESFHFTGHQ-----W--LTIDKQEGVYAGGKAEYTGIKTFEVQSDF 1415
            .:...|..::     |.|...|..|..|     |  |..|:..|  ..|:.||: :...:...:|
Mouse  1738 LVNVNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTFLAHDRDSG--PNGQVEYS-VVDGDPLGEF 1799

  Fly  1416 QRSCLD-------DIRLDGKHLP------------LPPAMNGTQWG--------QATMARNLERN 1453
            ..|.::       |:.||.:.:.            :||..:....|        ...:..||..|
Mouse  1800 VISPVEGVLRVRKDVELDRETIAFYNLTICARDRGVPPLSSTMLVGIRVLDINDNDPVLLNLPMN 1864

  Fly  1454 --CPSNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDT-KGC----------VDRNECLDLP 1505
              ...|.|.|:.:                    ..:::||. .||          .:|.....:.
Mouse  1865 VTISENSPVSSFV--------------------AHVLASDADSGCNALLTFNITAGNRERAFFIN 1909

  Fly  1506 CLNGATCINLEPRLRYRCICPEGYWGENCELVQEGQRLKLSMGALGAIFVCLIIILILALIFVLY 1570
            ...|...:| .|..|.|  .||             .||.:|:                       
Mouse  1910 ATTGIVTVN-RPLDRER--IPE-------------YRLTVSV----------------------- 1935

  Fly  1571 SRKRKTTKKKKRSGPE------KDVRETVISYEDEGG-------GEDDMTAFDITPLQIPISAQG 1622
                       :..||      ||....::|..||..       |.......:.:|...|::...
Mouse  1936 -----------KDNPENPRIARKDFDLLLVSLADENDNHPLFTEGTYQAEVMENSPAGTPLTVLN 1989

  Fly  1623 GPPDIAACKMPIIYPVMT--LLPPGQEL----NVAYLMEERKQ-RIDKDNNAPPFDDLRNFTFEG 1680
            | |.:|......:|.|:|  ||....:|    |...::..|.. .||::..:|||.:|.      
Mouse  1990 G-PILALDADEDVYAVVTYQLLGTHSDLFVIDNSTGVVTVRSGIIIDREAFSPPFLELL------ 2047

  Fly  1681 SGSIAESLSSLASGTD-------DENQDF----------NYLQNWGPRFNALAAMYVHDKAKASS 1728
              .:||.:..| :||.       |:|.::          :.|:|..|.|:.|......:.:..:.
Mouse  2048 --LLAEDIGQL-NGTAHLFITILDDNDNWPTFSPPTYTVHLLENCPPGFSVLQVTATDEDSGLNG 2109

  Fly  1729 QLPSDGGGGSGDGPGPGASSSSPLGGGGTGGGSGIPGNV-----LAVVATGSGAGPGGG 1782
            :|......|:.|     .....|:.|....|.:.|....     |.||||..|..|..|
Mouse  2110 ELVYRIEAGAQD-----RFLIHPVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSG 2163

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 32/94 (34%)
Cadherin_repeat 140..248 CDD:206637 33/112 (29%)
Cadherin_repeat 256..359 CDD:206637 35/106 (33%)
Cadherin_repeat 379..481 CDD:206637 27/107 (25%)
Cadherin_repeat 489..586 CDD:206637 32/96 (33%)
Cadherin_repeat 594..703 CDD:206637 28/111 (25%)
Cadherin_repeat 724..801 CDD:206637 18/86 (21%)
EGF_CA 977..1010 CDD:238011 0/32 (0%)
LamG 1013..1198 CDD:238058 45/242 (19%)
EGF_2 <1233..1259 CDD:285248 2/25 (8%)
Laminin_G_2 1293..1428 CDD:280389 31/172 (18%)
EGF_CA 1497..1535 CDD:238011 8/37 (22%)
Cadherin_C 1583..1719 CDD:279398 39/172 (23%)
Cdh23XP_017169419.1 Cadherin_repeat 51..137 CDD:206637
Cadherin_repeat 145..240 CDD:206637
Cadherin_repeat 249..353 CDD:206637
Cadherin_repeat 361..463 CDD:206637 3/9 (33%)
Cadherin_repeat 472..564 CDD:206637 32/94 (34%)
Cadherin_repeat 573..674 CDD:206637 33/111 (30%)
Cadherin_repeat 683..781 CDD:206637 36/106 (34%)
Cadherin_repeat 789..893 CDD:206637 29/119 (24%)
Cadherin_repeat 901..997 CDD:206637 31/95 (33%)
Cadherin_repeat 1006..1105 CDD:206637 28/112 (25%)
Cadherin_repeat 1113..1210 CDD:206637 21/97 (22%)
Cadherin_repeat 1225..1315 CDD:206637 17/119 (14%)
Cadherin_repeat 1324..1421 CDD:206637 18/145 (12%)
Cadherin_repeat 1433..1530 CDD:206637 17/98 (17%)
Cadherin_repeat 1540..1637 CDD:206637 18/119 (15%)
Cadherin_repeat 1645..1747 CDD:206637 19/118 (16%)
Cadherin_repeat 1759..1854 CDD:206637 18/97 (19%)
Cadherin_repeat 1862..1962 CDD:206637 26/169 (15%)
Cadherin_repeat 1970..2072 CDD:206637 26/111 (23%)
Cadherin_repeat 2080..2176 CDD:206637 20/89 (22%)
Cadherin_repeat 2187..2296 CDD:206637
Cadherin_repeat 2308..2405 CDD:206637
Cadherin_repeat 2413..2511 CDD:206637
Cadherin_repeat 2520..2614 CDD:206637
Cadherin_repeat 2627..2725 CDD:206637
Cadherin_repeat 2742..2848 CDD:206637
Cadherin_repeat 2857..2958 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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