DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Pcdh17

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_006518968.1	Gene:	Pcdh17 / 219228	MGIID:	2684924	Length:	1185	Species:	Mus musculus

Alignment Length:	856	Identity:	202/856 - (23%)
Similarity:	332/856 - (38%)	Gaps:	223/856 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 DNPANSKFDINRTTGDIFVLKPLDRD---QPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDIN 246
            :|.|....|::..:|.::..:.:||:   :.|.:.|....|||.|:      ....|:|.::|||
Mouse    69 ENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDK------EICMIKVEIQDIN 127

  Fly   247 DNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIE 311
            ||||.||......:::||...|:.....||   .||:...|....|.:.:    ::.|....:::
Mouse   128 DNAPSFPSDQIEMDISENAAPGTRFPLTSA---HDPDAGENGLRTYLLTR----DDHGLFALDVK 185

  Fly   312 --------PETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVK--DLNDMPPQFTK 366
                    ||..:.|    .||||....:::.:.|:|||....:.|..|.||  |.||..|.|..
Mouse   186 SRGDGTKFPELVIQK----ALDRELQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEA 246

  Fly   367 DEWVTEVDETN--GTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD-GTGSLK 428
            ..::.|:.|..  ||.:.:   |..|..||.......|..   |.:..|:...:.:.| .||.::
Mouse   247 PSYLVELPENAPLGTVVID---LNATDADEGPNGEVLYSF---SSYVPDRVRELFSIDPKTGLIR 305

  Fly   429 IIQPLDYEDPLQSSGFRFRIQVNDKGDDG-PGGSDKYHVAYSWVVVKLRDINDNVPKFDREHI-E 491
            :...||||   ::......:|..|.|.:. |        |:..|.|||.|.|||.|......: :
Mouse   306 VKGNLDYE---ENGMLEIDVQARDLGPNPIP--------AHCKVTVKLIDRNDNAPSIGFVSVRQ 359

  Fly   492 VSIYEDTKVGTILEQFKATDADQGGHSKVAYKIV------------RSTNRKRQFAISDRGAVSI 544
            .::.|....||::...:.||.|.|.:.::..:::            .|...|.:....:...|..
Mouse   360 GALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGLGGPGSVPFKLEENYDNFYTVVT 424

  Fly   545 QRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQD-YKPTLPE-NVSGKKI 607
            .|||||||||.:::.|:|.|.|||...:|.:..|.:.|.|||.|.|.:. |...:.| |:.|:.:
Mouse   425 DRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAVKILDENDNPPRFTKGLYVLQVHENNIPGEYL 489

  Fly   608 LEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKS 672
            ..|.|:|||   .|..|..::.:.|....::.....|..    :..||.  |.:||.|:.|..|:
Mouse   490 GSVLAQDPD---LGQNGTVSYSILPSHIGDVSIYTYVSV----NPTNGA--IYALRSFNYEQTKA 545

  Fly   673 YAIPIEIKDNGAPA-MTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDD 736
            :...:..||:|||| :...:|:.||:.|||||     :..:::...|             ||..:
Mouse   546 FEFKVLAKDSGAPAHLESNATVRVTVLDVNDN-----APVIVLPTLQ-------------NDTAE 592

  Fly   737 WDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDI 801
            ..||.......:....| .||:|.|        ..||  |.:::.|   |.:|
Mouse   593 LQVPRNAGLGYLVSTVR-ALDSDFG--------ESGR--LTYEIVD---GNDD------------ 631

  Fly   802 TAEAVQQAGSMRLSHITDED----FVRTWNPVKNQVEPSKLERFRNKLAELL--YTDRDNVDVFS 860
                          |:.:.|    .:||.:|....|.|         :.||:  .||.....:.:
Mouse   632 --------------HLFEIDPSSGEIRTLHPFWEDVTP---------VVELVVKVTDHGKPTLSA 673

  Fly   861 V----------QLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHREEIEKDVGLNITMVN 915
            |          .|.||.|                      |:||      |:...|:.|
Mouse   674 VAKLIIRSVSGSLPEGVP----------------------RVNG------EQHHWDMSL------ 704

  Fly   916 INECLHEGKGKCGSNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCR-- 978
                                      |..|:::..:::.:...|:....|:..|...:.:|||
Mouse   705 --------------------------PLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIA 743

  Fly   979 --THLCYNGGR 987
              :|....||:
Mouse   744 EYSHPQLGGGK 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	17/65 (26%)
		Cadherin_repeat	256..359	CDD:206637	26/112 (23%)
		Cadherin_repeat	379..481	CDD:206637	26/103 (25%)
		Cadherin_repeat	489..586	CDD:206637	29/109 (27%)
		Cadherin_repeat	594..703	CDD:206637	33/110 (30%)
		Cadherin_repeat	724..801	CDD:206637	15/76 (20%)
		EGF_CA	977..1010	CDD:238011	5/15 (33%)
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Pcdh17	XP_006518968.1	Cadherin_2	21..112	CDD:369785	10/42 (24%)
		Cadherin_repeat	142..240	CDD:206637	27/108 (25%)
		Cadherin_repeat	248..348	CDD:206637	29/116 (25%)
		Cadherin_repeat	362..466	CDD:206637	29/103 (28%)
		Cadherin_repeat	475..577	CDD:206637	33/110 (30%)
		Cadherin_repeat	592..680	CDD:206637	25/136 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000