DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and Cdh12

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001008420.1	Gene:	Cdh12 / 215654	MGIID:	109503	Length:	794	Species:	Mus musculus

Alignment Length:	738	Identity:	203/738 - (27%)
Similarity:	329/738 - (44%)	Gaps:	150/738 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 DVDRPINIV-YFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQD-EG 228
            |:|:....| |.|:|.|      |.:.|.|:.|||||..::.|||::   :|.:.....|.| |.
Mouse    81 DLDKGEGTVKYTLSGDG------AGTVFTIDETTGDIHAIRSLDREE---KPFYTLRAQAVDIET 136

  Fly   229 GEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYS 293
            .:.|...::..:.::|||||.|:|..|.|..:|.|....|:.|:.:.|.|.|||....:|:::||
Mouse   137 RKPLEPESEFIIKVQDINDNEPKFLDGPYVASVPEMSPVGAYVLQVKATDADDPTYGNSARVVYS 201

  Fly   294 IEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRV 354
            |.:       |.|.|.|:|:||:|:||:..:|||....|.:.:.|.|.    |||.||...:|.:
Mouse   202 ILQ-------GQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTVVNITL 259

  Fly   355 KDLNDMPPQFTKDEWVTEVDETN--GTYIPETPILTVTVQDED--ETNTFQYKVVPNSGFGADKF 415
            .|:||.||:|.|..:..:|.|::  |:.|..     :...|.|  :....:|.:||  |.|.:.|
Mouse   260 TDVNDNPPRFPKSIFHLKVPESSPVGSAIGR-----IRAVDPDFGKNAEIEYNIVP--GDGGNLF 317

  Fly   416 AMVRNGD-GTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVA-----YSWVVVK 474
            .:|.:.| ..|.:|:.:|||:|   ....:.|:::.::...|     .::|.|     .:.|.:.
Mouse   318 DIVTDEDTQEGIIKLKKPLDFE---TKKAYTFKVEASNLHLD-----HRFHSAGPFKDTATVKIS 374

  Fly   475 LRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI-SD 538
            :.|: |..|.|.:....:.:||||.||||:....|.|.|.|. |.|.|.|...::.:..|.| ..
Mouse   375 VLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGS-SAVRYFIDWKSDGESYFTIDGT 437

  Fly   539 RGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVS 603
            .|.::....||||...:::..|:|....:|..|:...:.:.|.|||:..|..:..|:..:.||..
Mouse   438 EGTIATNELLDRENMAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAK 502

  Fly   604 GKKILE-VAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLR-PFD 666
            ..:|:: |.|.|.|  |...|..|:|||.|.|  .||..|.|.     |..|..|.|.:.| .:.
Mouse   503 PGQIIQIVGAVDRD--LSPAGQQFSFRLAPEA--VIKPNFTVH-----DFRNNTAGIETRRNGYS 558

  Fly   667 REAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQDTPIGRVYV 731
            |..|:.|.:||.|:|:..|..:.|:|:|:.:...:.:      .::|..|.  ::...|:|
Mouse   559 RRQQELYFLPIVIEDSSYPVQSSTNTMTIRVCRCDSD------GTILSCNV--EAIFLPVG---- 611

  Fly   732 NDPDDWDVPDKKYYWEVQEHQRFKLDTDT------------GILTMRAGTRRGRYQ--------- 775
                                    |.|..            .|:.:....||.|.:
Mouse   612 ------------------------LSTGALIAILLCMVILLAIVVLYVALRRQRKKDTLMTSKED 652

  Fly   776 LRFKV--YDRE-HGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSK 837
            :|..|  ||.| .|:||..|      .||        |::|...:.:|      |.::..::|..
Mouse   653 IRDNVIHYDDEGGGEEDTQA------FDI--------GALRNPKVIEE------NKIRRDIKPDS 697

  Fly   838 --LERFRNKLAELLYTDRDNVDV 858
              |.|.|.::       .||.|:
Mouse   698 LCLSRQRPQV-------EDNTDI 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	26/83 (31%)
		Cadherin_repeat	256..359	CDD:206637	37/106 (35%)
		Cadherin_repeat	379..481	CDD:206637	23/109 (21%)
		Cadherin_repeat	489..586	CDD:206637	31/97 (32%)
		Cadherin_repeat	594..703	CDD:206637	36/110 (33%)
		Cadherin_repeat	724..801	CDD:206637	17/100 (17%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh12	NP_001008420.1	CA	80..158	CDD:214520	28/85 (33%)
		Cadherin_repeat	164..265	CDD:206637	38/107 (36%)
		Cadherin_repeat	273..380	CDD:206637	26/122 (21%)
		Cadherin_repeat	389..484	CDD:206637	30/95 (32%)
		Cadherin_repeat	492..590	CDD:206637	36/106 (34%)
		Cadherin_C	638..785	CDD:395833	25/103 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010