DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and DSG3

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001935.2 Gene:DSG3 / 1830 HGNCID:3050 Length:999 Species:Homo sapiens


Alignment Length:586 Identity:162/586 - (27%)
Similarity:257/586 - (43%) Gaps:105/586 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 TTG-------VIYVASPLDYETRPRY---ELRL-EATRNRKNNYTTVVINVRDVNDNPPVFDRQT 140
            |||       ||.|...|..||:.:|   |:.: :|.|.:|..:.......|:..||        
Human     8 TTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDN-------- 64

  Fly   141 YRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLK 205
                    ..||   .|.::|:   |......|.|.::|.||  |.|....|.:::.||||.:..
Human    65 --------SKRN---PIAKITS---DYQATQKITYRISGVGI--DQPPFGIFVVDKNTGDINITA 113

  Fly   206 PLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSS 270
            .:||::   .|.:..|..|.:..|..:.....:.|.:.|||||.|.|.|.|:.|.:.||..:.|.
Human   114 IVDREE---TPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSL 175

  Fly   271 VMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQ 335
            ||.::|.|.|:||. .|:|:.:.|   |.:|..|.|:|.:...||.::|....||||:...|.:.
Human   176 VMILNATDADEPNH-LNSKIAFKI---VSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLV 236

  Fly   336 V--VAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETN 398
            |  ...||.||......:|:|||:||..|.|...::...::|.    |..:.:|...|.|.||..
Human   237 VSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEEN----ILSSELLRFQVTDLDEEY 297

  Fly   399 TFQYKVVP--NSGFGADKFAM---VRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGP 458
            |..:..|.  .||...:.|.:   .|..:|.  ||:::.||||. |||  .:..|.|.:|.:...
Human   298 TDNWLAVYFFTSGNEGNWFEIQTDPRTNEGI--LKVVKALDYEQ-LQS--VKLSIAVKNKAEFHQ 357

  Fly   459 GGSDKYHVAYSWVVVKLRDINDNV---PKFDREHIEVSIYEDTKVGTILEQFKATDAD------- 513
            ....:|.|..:.|.:::.::.:.:   |......::..|.....|..||..::|.|.|       
Human   358 SVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASN 422

  Fly   514 --------QGGH----SKVA-YKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDD 565
                    .||:    ||.| .|.|::.||...|.::        :.:..|        :||||:
Human   423 VKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVN--------KTITAE--------VLAIDE 471

  Fly   566 GSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRL 630
            .: .:|:|.|:.|.|.|.|||.||...:.......:.|    :.|:|:..::|..   ||:||.|
Human   472 YT-GKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPS----VVVSARTLNNRYT---GPYTFAL 528

  Fly   631 D 631
            :
Human   529 E 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 15/55 (27%)
Cadherin_repeat 140..248 CDD:206637 27/107 (25%)
Cadherin_repeat 256..359 CDD:206637 37/104 (36%)
Cadherin_repeat 379..481 CDD:206637 28/106 (26%)
Cadherin_repeat 489..586 CDD:206637 29/116 (25%)
Cadherin_repeat 594..703 CDD:206637 9/38 (24%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
DSG3NP_001935.2 CA 82..155 CDD:214520 24/77 (31%)
Cadherin_repeat 165..263 CDD:206637 36/101 (36%)
Cadherin 272..375 CDD:278457 29/111 (26%)
Cadherin_repeat 402..491 CDD:206637 28/105 (27%)
Desmoglein repeat 1 910..935
Desmoglein repeat 2 936..966
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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