DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and DSG2

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001934.2 Gene:DSG2 / 1829 HGNCID:3049 Length:1118 Species:Homo sapiens


Alignment Length:1159 Identity:239/1159 - (20%)
Similarity:424/1159 - (36%) Gaps:348/1159 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 VINVRDVN---DNPPVFDRQ-----TYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTG 179
            |::.|:.|   ...|...||     |....:.|.:|.:....|.:: .:|...:|.:.|.|..||
Human    28 VLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKI-HSDLAEERGLKITYKYTG 91

  Fly   180 QGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKD 244
            :||  ..|....|..|:.||::.|...|||::   .|.:..|.:|.|..|..:....::::.:.|
Human    92 KGI--TEPPFGIFVFNKDTGELNVTSILDREE---TPFFLLTGYALDARGNNVEKPLELRIKVLD 151

  Fly   245 INDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFE 309
            ||||.|.|.|.::.|:|.|...|.:.||.::|.|.|:|| :.|:|:.|.|   |..|....|:|.
Human   152 INDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPN-TLNSKISYRI---VSLEPAYPPVFY 212

  Fly   310 IEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGG------LKGTGTASIRVKDLNDMPPQFTKD- 367
            :..:||.|.|....||||....|::.|.|.||.|      :| .....||:.|:||..|..... 
Human   213 LNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVK-QAQVQIRILDVNDNIPVVENKV 276

  Fly   368 -EWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGAD----KFAMVRNGDG---- 423
             |.:.|.::.|      ..:..:.|.|.||             .|:|    .|......:|    
Human   277 LEGMVEENQVN------VEVTRIKVFDADE-------------IGSDNWLANFTFASGNEGGYFH 322

  Fly   424 --------TGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDIND 480
                    .|.:.:|:.:|||   :.....|.:.|.:|.........||......:.||::::.:
Human   323 IETDAQTNEGIVTLIKEVDYE---EMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKE 384

  Fly   481 NVPKFDREHIE---VSIY-----EDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI- 536
            .:      |.:   :|||     :.:..|.|:..|:|.|.|.|..:...|  |:..:|....:: 
Human   385 GI------HFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARY--VKLEDRDNWISVD 441

  Fly   537 SDRGAVSIQRPLDRETQ----DRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPT 597
            |....:.:.:..|.|::    ..:.::|:||.:..|.:|.|.|:.:.|:|:|||.||..:..:..
Human   442 SVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTI 506

  Fly   598 LPENVSGKKILEVAAKDPDDRLRGNGGPFTFRL---DPLASDEIKAGFKVEYDRRGDNENGVAII 659
            ..:    .:.:.|.|:|.|.  ..|.|||:|.:   .|..:::.|..          .:...:::
Human   507 CHD----AEYVNVTAEDLDG--HPNSGPFSFSVIDKPPGMAEKWKIA----------RQESTSVL 555

  Fly   660 SSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDV----------NDN--KMQPGSKSV 712
              |:..:::..:| .|...|.||...:......||:|:.:.          :|:  .:.|.:.::
Human   556 --LQQSEKKLGRS-EIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIAL 617

  Fly   713 LVYNY----------------QGQSQDTPI-GRV-----YVND---PDDWDVPDKKYYWEVQEHQ 752
            ::..:                :|....||| |.:     :.|:   |:|..||.           
Human   618 MILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPS----------- 671

  Fly   753 RFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHI 817
              .|..|.|      |:..||           :|           |..:..||..:..|      
Human   672 --FLPVDQG------GSLVGR-----------NG-----------VGGMAKEATMKGSS------ 700

  Fly   818 TDEDFVRTWNPVKNQVEPSKLE---------------RFRNKLAELLYTDRDNVDVFSVQLKEGS 867
                   :.:.||.|.|.|:::               :|......::.|     :........|:
Human   701 -------SASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTT-----ETTKTARATGA 753

  Fly   868 PYPLTDVHFAARSATQQ---PYF--KAVRLNGVVQMHREEIEKDVGLNITMVNINECLHEGKGKC 927
            ...:.....||.:..::   .||  ||.       .:.||.|.....:..:|...|   |.:...
Human   754 SRDMAGAQAAAVALNEEFLRNYFTDKAA-------SYTEEDENHTAKDCLLVYSQE---ETESLN 808

  Fly   928 GSNSCTSKVE----------LGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCRTH-L 981
            .|..|.|.:|          ||.|..|::   ...:|.::||:.:...|.:..|....|..:| |
Human   809 ASIGCCSFIEGELDDRFLDDLGLKFKTLA---EVCLGQKIDINKEIEQRQKPATETSMNTASHSL 870

  Fly   982 C----------YNGG------------------------RCVETRNGPKCVACPVGYNGPRCQQS 1012
            |          |:.|                        |.|.:|...| ||.|:          
Human   871 CEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQK-VATPL---------- 924

  Fly  1013 TRSFRGNGWAWYPPLQLCQESHLSLE--FITRVADGLILYNGPIVPP--------KPEETVISDF 1067
                         |..:...:.::.|  ::|          |..:||        :|:..::::.
Human   925 -------------PDPMASRNVIATETSYVT----------GSTMPPTTVILGPSQPQSLIVTER 966

  Fly  1068 I----ALELEQGY---------PRLLIDFGSGTLELRVKTKKTLDDGVWHRLDI 1108
            :    :..::|.|         .|::...|.|:..|         :|..|..|:
Human   967 VYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPL---------EGTQHLQDV 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 3/11 (27%)
Cadherin_repeat 140..248 CDD:206637 29/107 (27%)
Cadherin_repeat 256..359 CDD:206637 37/108 (34%)
Cadherin_repeat 379..481 CDD:206637 20/117 (17%)
Cadherin_repeat 489..586 CDD:206637 27/109 (25%)
Cadherin_repeat 594..703 CDD:206637 20/121 (17%)
Cadherin_repeat 724..801 CDD:206637 17/85 (20%)
EGF_CA 977..1010 CDD:238011 12/67 (18%)
LamG 1013..1198 CDD:238058 16/119 (13%)
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
DSG2NP_001934.2 Cadherin_repeat 62..155 CDD:206637 27/98 (28%)
Cadherin_repeat 163..268 CDD:206637 38/109 (35%)
Cadherin_repeat 276..382 CDD:206637 23/127 (18%)
Cadherin_repeat 392..495 CDD:206637 26/104 (25%)
Desmoglein repeat 1 881..912 3/30 (10%)
Desmoglein repeat 2 913..942 7/52 (13%)
Desmoglein repeat 3 943..968 4/24 (17%)
Desmoglein repeat 4 969..992 3/22 (14%)
Desmoglein repeat 5 993..1021 6/28 (21%)
Desmoglein repeat 6 1022..1051
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1068..1118
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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