Protein Alignment CadN2 and DSC3

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_001932.2
• Gene: DSC3 / 1825
• HGNCID: 3037
• Length: 896
• Species: Homo sapiens
• Alignment Length: 667
• Identity: 178/667 - (26%)
• Similarity: 292/667 - (43%)
• Gaps: 136/667 - (20%)

  Fly    82 FAVQNTTGVIYVASPLDYETRPR-YELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQI 145
            |.|.| .|.:|.|..:....:.| :.:.|...|.:.....||::.          ..::..:|:.
Human    71 FRVLN-DGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLE----------HQKKVSKTRH 124

  Fly   146 TEE-----------------DDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFD 193
            |.|                 .:.:|....|.:...:.|..:...:.|.::|:|:|.: |.| .|.
Human   125 TRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKE-PLN-LFY 187

  Fly   194 INRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYAD------------IQVNLKDIN 246
            |.|.||::|..:|:||::        :.||       .|:.||.            :.:.::|.|
Human   188 IERDTGNLFCTRPVDREE--------YDVF-------DLIAYASTADGYSADLPLPLPIRVEDEN 237

  Fly   247 DNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP-IFEI 310
            ||.|.|.:.||...|.|:...|::|..:.|.|.|:| ::.:.:|.|||    :::...:| :|.:
Human   238 DNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEP-DTMHTRLKYSI----LQQTPRSPGLFSV 297

  Fly   311 EPETGLIKTAVCCLDRERTPDYSI--QVVAMDGG--GLKGTGTASIRVKDLNDMPPQFTKDEWVT 371
            .|.||:|.|....||||....||:  :|..|||.  ||.||.|..|.|.|.||..|.|.::.:..
Human   298 HPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEA 362

  Fly   372 EVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD------------GT 424
            .|:| |...:   .||.:.::|:|..||..::|         .|.:::..:            ..
Human   363 FVEE-NAFNV---EILRIPIEDKDLINTANWRV---------NFTILKGNENGHFKISTDKETNE 414

  Fly   425 GSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVA---YSWVVVKLRDINDNVPKFD 486
            |.|.:::||:||:..|   ....|.||   ::.|...|...|.   .:.|.|.:||: |..|:..
Human   415 GVLSVVKPLNYEENRQ---VNLEIGVN---NEAPFARDIPRVTALNRALVTVHVRDL-DEGPECT 472

  Fly   487 REHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISD-RGAVSIQRPLDR 550
            .....|.|.|:..||:.:..:||.|.:....:.:.||  :..:.|....|.: .|::...:.|||
Human   473 PAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDR 535

  Fly   551 ETQ----DRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDY----KPTLPENVSGKKI 607
            |.:    :.::|.:||||...  |:.|.||.|.::|||||.|...|:|    ||.:       ..
Human   536 EVETPKNELYNITVLAIDKDD--RSCTGTLAVNIEDVNDNPPEILQEYVVICKPKM-------GY 591

  Fly   608 LEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQ-K 671
            .::.|.|||:.:  :|.||.|.| |..|.||...:.:      ...|..|...|   :.:.|. :
Human   592 TDILAVDPDEPV--HGAPFYFSL-PNTSPEISRLWSL------TKVNDTAARLS---YQKNAGFQ 644

  Fly   672 SYAIPIEIKDNGAPAMT 688
            .|.|||.:||....|.|
Human   645 EYTIPITVKDRAGQAAT 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	11/50 (22%)
		Cadherin_repeat	140..248	CDD:206637	28/136 (21%)
		Cadherin_repeat	256..359	CDD:206637	39/107 (36%)
		CA	388..483	CDD:214520	24/109 (22%)
		Cadherin_repeat	489..586	CDD:206637	30/101 (30%)
		Cadherin_repeat	594..703	CDD:206637	28/100 (28%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
DSC3	NP_001932.2	Cadherin_pro	27..111	CDD:214999	9/40 (23%)
		Cadherin	140..234	CDD:394985	23/110 (21%)
		Cadherin_repeat	247..351	CDD:206637	40/108 (37%)
		Cadherin	360..462	CDD:394985	26/120 (22%)
		Cadherin_repeat	477..573	CDD:206637	30/99 (30%)
		CA_like	<596..669	CDD:481204	25/78 (32%)
		CADH_Y-type_LIR	841..891	CDD:460041