DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and hmr-1

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001021650.1 Gene:hmr-1 / 173007 WormBaseID:WBGene00001980 Length:2920 Species:Caenorhabditis elegans


Alignment Length:1784 Identity:541/1784 - (30%)
Similarity:822/1784 - (46%) Gaps:298/1784 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQITGGNIGN-AFAVQ 85
            |:|.|.|.||:.|.|:...|...:.|:......|:|:.|.|.::.:|:||.:.|...|. .|.|:
 Worm  1321 VQIVINDVNDNAPSFEEQKYIGRVKESEGEGHDVITIKAHDLDKHSNLRYHLIGAGGGRIPFGVR 1385

  Fly    86 NTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDD 150
            ..:|.|:|..|||:|...:|.|.|.|:..|.|..|.|.|::.|||||.|.|::|.|.|.:.|| |
 Worm  1386 TDSGTIFVKEPLDFEASDQYHLVLIASDGRHNATTNVYIHIEDVNDNAPQFEQQKYATTVIEE-D 1449

  Fly   151 RNLPKRILQVTATDGDVD-RPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNG 214
            .::||.:..|.|||.|.| :...|||.|.|||      |:..|.|.:.:|.|.::|.||||.|.|
 Worm  1450 VDIPKVLFNVHATDADQDEKSSRIVYRLEGQG------ADEVFRIGKYSGTIELVKALDRDPPAG 1508

  Fly   215 RPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTEN----GTAGSSVMTMS 275
            .|.|.|.|.|.|:.|.|||||||:|||::|||||:|.||:.: ||.:.||    .:.|...|.:.
 Worm  1509 VPSWNFVVQAIDDDGNGLVGYADVQVNVRDINDNSPIFPERL-FGYIEENREPIHSDGVYFMDVQ 1572

  Fly   276 AVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTP--DYSIQVVA 338
            |.|:|||. :.||.:.|.|.:|.:  ..|..:|.|:..||.| .|:..||||.:.  ::.|:|.|
 Worm  1573 ARDFDDPT-TENANIEYGIVRNKL--INGESVFRIDQNTGKI-FAMRSLDREISSEREFIIEVRA 1633

  Fly   339 MDGG--GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPI----LTVTVQDEDE- 396
            .|.|  ..:|....:|:|.|:||..|.|.|..:...|:||       .||    ::.:..|.|| 
 Worm  1634 NDRGVPSREGFANVTIKVTDMNDNAPFFEKTRYEGSVEET-------APIGAAVMSFSAFDADEE 1691

  Fly   397 --TNTFQYKVVPNSGFGADKFAMVRNGD----GTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGD 455
              .|.|.|::...|    |.|.:..:.|    ..|.|::.|||||||..|..||...|:|     
 Worm  1692 AKDNVFTYQLSEES----DYFYVTTDKDSKQSSVGVLRVKQPLDYEDVTQRDGFHLGIRV----- 1747

  Fly   456 DGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHI----EVSIYEDTKVGTILEQFKATDADQGG 516
                 ||..|.|.:.|.|.|.|.||:.|     ||    |..:.||...||.:.::.|||.|.|.
 Worm  1748 -----SDGRHDAEAAVHVALVDRNDHAP-----HIHGATEHRVREDVPRGTSIGRYTATDRDAGD 1802

  Fly   517 HSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVK 581
            .::  ::|.|.::.||||.|...|.:.:...||||....:::.|.|.|:.:  ......:.|.::
 Worm  1803 TAR--FRINRQSDPKRQFTIDQDGTLRVAHTLDREDIAVYNLIIEAYDNSN--NIGRQMVAVYLQ 1863

  Fly   582 DVNDNAPTFAQDYKPTLP------ENVSGKKI--LEVAAKDPDDRLRGNGGPFTFRLDPLASDEI 638
            |||||.|   :.|  |:|      ||....::  .|:.|.|.|  ....|.|||..:.|  |.:.
 Worm  1864 DVNDNGP---EPY--TVPRPCIFRENTPVNQLGTCEIRATDRD--TAEFGPPFTMEVSP--SFKY 1919

  Fly   639 KAGFKVEYDRRGDNENGVAIISSLRPFDREAQ---KSYAIPIEIKDNGAPAMTGTSTLTVTIGDV 700
            .....|.::..||..||...|:.|:.|||||.   |...||:.:.|..  .....:::.|.|||:
 Worm  1920 SQYLNVIFNANGDGGNGSMTITPLQEFDREAPVPGKILEIPLILADRA--GRRNEASVHVIIGDL 1982

  Fly   701 NDNKMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTM 765
            |||.|..|..::.|.:|.|:.::|.||||||:|.||||:.||.:.|: .....|:| :|.|.:||
 Worm  1983 NDNTMHDGRMTIHVNSYLGRLKETVIGRVYVDDADDWDLGDKTFSWK-DSRPGFEL-SDKGSITM 2045

  Fly   766 RAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDE-------DFV 823
            ......|.|.:...|:|... .||....::|.|..:...|....||::|. |.:|       ||:
 Worm  2046 AGEMAAGTYTMSANVHDNAR-DEDAVGYVTVIVNAVPQIAFDNQGSVQLL-IAEETPLQLPDDFI 2108

  Fly   824 RTWNPVKNQVEPSKLERFRNKLAELLYTDRDNVDVFSVQL----KEGSPYPLTDVHFAARSATQQ 884
            |.     :....|.::.|:.::...:..| ..|||||||:    .:....|:.:|.|.||.:|  
 Worm  2109 RA-----DSNGQSLMDTFKQEMTAYMGGD-VTVDVFSVQVGIATLQTRDVPVLNVRFNARGST-- 2165

  Fly   885 PYFKAVRLNGVVQMHREEIEKDVGLNITMVNINECLHEGKGKCGSNSCTSKVELGKKPY---TVS 946
             |....:|||::..||.::::.:.:.|..|.|:.|...   :|.:...|    |....|   .||
 Worm  2166 -YRDTAQLNGLIAAHRADLQRKLNVEIVGVGIDMCKFT---QCDAGCQT----LNSADYDGIVVS 2222

  Fly   947 VNRTALVGVRLDISAQCVC---RARNFTHQDHNCRTHLCYNGGRCVETRNGPKCVACPVGYNGPR 1008
            .|.|.:|||.......|.|   ||      ...|:..||:|.|.|..|..|..|.....|..|.|
 Worm  2223 ANSTVIVGVNATSRDDCTCPVWRA------PPACQHSLCHNDGVCHNTNPGFFCECRNDGLKGAR 2281

  Fly  1009 CQQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRVADGLILYNGPIVPPKPEETV-ISDFIALEL 1072
            ||.:||||.|||:|||.|:..|...::|..|:|..:|.|:.||||:...:.:..: .||:|.::|
 Worm  2282 CQGTTRSFGGNGFAWYKPMPACTSLNISFSFMTTQSDALLFYNGPLETLRNDTHIEYSDYIFIQL 2346

  Fly  1073 EQGYPRLLIDF-GSGTLELRVKTKKTLDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPP 1136
            ..|...|.:.. |.....|.| ....|:||.||.:.:..:.:.|.:|||.||.     :..|.  
 Worm  2347 RGGRISLEVSMNGQSRSSLEV-ASTALNDGTWHDISVNQEGKRVELVVDNCRF-----LGAGA-- 2403

  Fly  1137 EFDDNACQARGQIPPFAESLNLNQPLQLGG---LYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHN 1198
              ||::|:|....|...|.||:..|:|:||   |..|.:.||:       ...|.:||:||:..|
 Worm  2404 --DDSSCRAELYTPDDDERLNIVTPVQIGGLAPLSGQDYPQTI-------PRAGLNGCVRNLNVN 2459

  Fly  1199 SEHYDLAFPALARNSFPACPQTDEVC--LKTEHTARCWEHGNCVASL-----VQAKCHCQPGWMG 1256
            .:.||||.||..:||...|......|  ...:....| .||:|.|.:     :.|||.|.|||.|
 Worm  2460 GDQYDLATPAFEQNSEKGCRLWGATCDSNSVDSLNHC-IHGDCFADVQGSGAMVAKCVCDPGWGG 2523

  Fly  1257 PGCNVPTIPTTFKAQSYVKFA----------LSFEPDRFSTQLQLRFRTREQGG---ELFRVSDQ 1308
            ..|.        :...:::||          ::| |::.| .::|.|.:.:..|   ||...:|.
 Worm  2524 ARCE--------RRMEWIQFAQGAFIEYSPRIAF-PEQVS-DIELLFISGKVNGAPAELSFGTDS 2578

  Fly  1309 HHREYAILELRRGH----LQFRYNLNS-MRNEEQLLTLTAIAVNDGQWHVIRISRYGSAALMELD 1368
             .:.|....|..|.    ...::::.: .|...|.|.::.:.:.:...:.::.:|..:.|.:.:|
 Worm  2579 -QQSYVSTNLESGQNGVTAAGKFDIGTGGRRARQELRVSEVLLKENASYWLQFTRNPTRASLSID 2642

  Fly  1369 GGESRRYNESFHFTGHQWLTIDKQE-------GVYAGGKAEYTGIKTFEVQSDFQRSCLDDIRLD 1426
            ..    |..|        ..:||.|       .:..|.:.:..|         || .|:...|..
 Worm  2643 NA----YTVS--------TQLDKGEPFSLQVNQITLGTQGQNKG---------FQ-GCIGTYRWS 2685

  Fly  1427 GKHLPLP--PAMNGTQWGQATMAR--NLERNCPSNRPCSNV---ICPDPFDCVDLWNEYECTCSE 1484
            .::|||.  .||:..:....:::.  .::..|.....|:::   .|...|.|||.|....|||::
 Worm  2686 KQNLPLKRGGAMDENEESIVSISNMAGVQDGCDLRITCADLPAGYCGGSFVCVDFWKGPFCTCND 2750

  Fly  1485 G--RIMSSDTK--GCVDRNECLDLPCLNGATCINLEPRLRYRCICPEGYWGENCELVQEGQRLKL 1545
            |  .|:..|.:  ||                                   ||...:    .:|.:
 Worm  2751 GANAILGDDGQVVGC-----------------------------------GETLAV----SKLGI 2776

  Fly  1546 SMGALGAIFVCLIIILILALIFVLYSRKRKTTKKKKRSGPEKDVRETVISYEDEGGGEDDMTAFD 1610
            |..|:..|.|.|.::::|.::.|:|:|:.....:..|  ||:..|:.:..|..|||||.|...:.
 Worm  2777 SSPAIILILVSLALLILLVMMMVVYTRRSPGAFENVR--PEEMNRDNLRQYGVEGGGEADNDQYS 2839

  Fly  1611 ITPLQIPI--------SAQGG-PPDIAACKMPIIYPVMTLLPP--GQELNVAYLMEERKQRIDKD 1664
            :..|:.|:        .|.|| ||.         ||...:.||  ..|||      .:.:.::.|
 Worm  2840 MAGLRKPVMPLDTGMGPAIGGHPPH---------YPPRGMAPPKDDHELN------SKIKDLETD 2889

  Fly  1665 NNAPPFDDLRNFTFEGSGSIAESLSSLAS 1693
            .||.|:|:||.:..|.......:|.|:.|
 Worm  2890 QNAAPYDELRIYDDERDNISVVTLESIES 2918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 32/91 (35%)
Cadherin_repeat 140..248 CDD:206637 52/108 (48%)
Cadherin_repeat 256..359 CDD:206637 36/110 (33%)
Cadherin_repeat 379..481 CDD:206637 35/112 (31%)
Cadherin_repeat 489..586 CDD:206637 31/100 (31%)
Cadherin_repeat 594..703 CDD:206637 36/119 (30%)
Cadherin_repeat 724..801 CDD:206637 29/76 (38%)
EGF_CA 977..1010 CDD:238011 12/32 (38%)
LamG 1013..1198 CDD:238058 63/189 (33%)
EGF_2 <1233..1259 CDD:285248 13/30 (43%)
Laminin_G_2 1293..1428 CDD:280389 25/149 (17%)
EGF_CA 1497..1535 CDD:238011 2/37 (5%)
Cadherin_C 1583..1719 CDD:279398 35/122 (29%)
hmr-1NP_001021650.1 Cadherin_repeat 431..521 CDD:206637
Cadherin_repeat 534..638 CDD:206637
Cadherin_repeat 647..742 CDD:206637
Cadherin_repeat 752..861 CDD:206637
Cadherin_repeat 875..975 CDD:206637
Cadherin_repeat 983..1085 CDD:206637
Cadherin_repeat 1103..1206 CDD:206637
Cadherin_repeat 1216..1331 CDD:206637 5/9 (56%)
Cadherin_repeat 1340..1432 CDD:206637 32/91 (35%)
Cadherin_repeat 1443..1542 CDD:206637 51/105 (49%)
Cadherin_repeat 1553..1657 CDD:206637 35/107 (33%)
Cadherin_repeat 1666..1768 CDD:206637 38/122 (31%)
Cadherin_repeat 1779..1868 CDD:206637 28/92 (30%)
EGF_CA 2250..2283 CDD:238011 12/32 (38%)
LamG 2286..2459 CDD:238058 63/189 (33%)
LamG 2533..2679 CDD:304605 29/170 (17%)
Cadherin_C 2812..>2919 CDD:279398 36/124 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 80 1.000 Domainoid score I5555
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1193 1.000 Inparanoid score I98
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4879at33208
OrthoFinder 1 1.000 - - FOG0001479
OrthoInspector 1 1.000 - - otm14448
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2878
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.870

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