DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN2 and Fat1

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:XP_006509330.1 Gene:Fat1 / 14107 MGIID:109168 Length:4645 Species:Mus musculus


Alignment Length:1785 Identity:438/1785 - (24%)
Similarity:709/1785 - (39%) Gaps:410/1785 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 TKFVRIGIADKNDSPPYFDRFLYE---TEIDENADLQSTVLTVNAKDHNESTNIRYQITGGNIGN 80
            |..|.:.:.|.|||||.|...:|:   :|.|....:.:.:.|.:|.....:..:.|.||||:...
Mouse  2926 TAIVGVTVTDVNDSPPRFTAEIYKGTVSEDDPPGGVIAILSTTDADTEEINRQVSYFITGGDALG 2990

  Fly    81 AFAVQNTTG--VIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRT 143
            .|||:|...  .:||..|||.|.:..|.|.:.||....::...|.:.|.|.|||.||.::.:|..
Mouse  2991 QFAVENVQSDWRVYVKKPLDREQKDSYLLTVTATDGTFSSKARVEVKVLDANDNSPVCEKTSYSD 3055

  Fly   144 QITEEDDRNLP-KRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPL 207
            .|.|:   .|| |.::||:|||.|:.....|.|.|.|.|.:       ||.:|..||::..|..|
Mouse  3056 TIPED---ALPGKLVMQVSATDADIRSNAEITYTLFGSGAE-------KFKLNPDTGELRTLALL 3110

  Fly   208 DRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVM 272
            ||::   :..:...|.|.|.||...  .|.|.:.|:|:|||||:|....|...|.||...|:.:.
Mouse  3111 DREE---QAVYNLLVKATDGGGRSC--QAAIVLTLEDVNDNAPEFTAEPYTITVFENTEPGTPLT 3170

  Fly   273 TMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVV 337
            .:.|.|.|   ...|.|:.||:    :|...|.  |.|...:|:|:... .||||....|::.:.
Mouse  3171 RVQATDAD---TGLNRKISYSL----VESADGQ--FSINERSGIIQLEK-HLDRELQAVYTLTLK 3225

  Fly   338 AMDGG---GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDED-ETN 398
            |:|.|   .|..|||..:.|.|:||.||.|...|:...|.|   ..:..|.:|.|.....| |.|
Mouse  3226 AVDQGLPRRLTATGTVVVSVLDINDNPPVFEYREYGASVSE---DIVIGTEVLQVYAASRDIEAN 3287

  Fly   399 T-FQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSD 462
            . ..|.::..:..|  ||::   ...||::.||:.||||   .|..:...::..|.|.  |..||
Mouse  3288 AEITYAIISGNEHG--KFSI---DSKTGAIFIIESLDYE---SSHEYYLTVEATDGGT--PSLSD 3342

  Fly   463 KYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRS 527
                 .:.|.:.:.|||||.|.|.::.....:.||..:...:....|.|||...:|.:.|.|:..
Mouse  3343 -----VATVNINVTDINDNSPVFSQDTYTTVVSEDAALEQPVITIMADDADGPSNSHIHYSIIEG 3402

  Fly   528 TNRKRQFAISD-RGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFA 591
             |:...|.|.. ||.|.:.:||||||...:.:.:.|.|:|:|.|..|.|:.:.|.|||||||.|:
Mouse  3403 -NQGSPFTIDPVRGEVKVTKPLDRETISGYTLTVQAADNGNPPRVNTTTVNIDVSDVNDNAPLFS 3466

  Fly   592 QD-YKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNEN 654
            :| |...:.||.. |..:|::...|.|.  ..||.||.|   .:.|...:..|:|       |::
Mouse  3467 RDNYSVIIQENKPVGFSVLKLVVTDKDS--SHNGPPFFF---TIVSGNDENAFEV-------NQH 3519

  Fly   655 GVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVY---- 715
            ||.:.::  ...|:.:..|.:.:::.|:|.|.::..:.:.:.:  :.::...|....:.::    
Mouse  3520 GVLLTAA--TIKRKVKDHYLLHVKVADSGKPQLSSMTHIDIRV--IEESIHPPAILPLEIFITAF 3580

  Fly   716 --NYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQ--RFKLDTDTGILTMRAGTRRGRYQL 776
              .|.|    ..||:::..|.|.:|.    ..:.:..|.  .|.:.:..|.|........|:|.|
Mouse  3581 GEEYSG----GVIGKIHATDQDVYDT----LMYSLDPHMDGLFSVSSTGGKLIAHRKLDIGQYLL 3637

  Fly   777 RFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRT-WNPVKNQVEPSKLER 840
            ...|.|   |:....|:::|.::.:|.|.:....::|.:::|.|:||.. |            ..
Mouse  3638 NVSVTD---GKFTTVADITVHIQQVTQEMLNHTVAIRFANLTPEEFVGDYW------------RN 3687

  Fly   841 FRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDV-HFAARS-----ATQQPYFKAVRLNGVVQMH 899
            |:..|..:|...::::.:.|:|..|  |:...|| .|..||     :|:|...|   :|..|   
Mouse  3688 FQRALRNILGVRKNDIQIVSLQPSE--PHSHLDVLLFVERSGGTHVSTKQLLHK---INSSV--- 3744

  Fly   900 REEIEKDVGLNITMVNINECLHEGKG-KCGSNSCTSKVELGKKPY-TVSVNRTALVGVRLDISAQ 962
             .::|:.:|:.|..|....|    .| .|....|..||.:.:... |.|..|.:.|..|...:|.
Mouse  3745 -TDVEEIIGVRILEVFQKLC----AGLDCPWKFCDEKVSVDENVMSTHSTARLSFVTPRHHRTAV 3804

  Fly   963 CVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPK--CVACPVGYNGPRCQQSTRSFRGNGWAWYP 1025
            |:|:........|.|..:.|..|..||......|  || ||.|..|.....|:.:|.||.:..|.
Mouse  3805 CLCKDGTCPPVHHGCEDNPCPAGSECVADPREEKYSCV-CPGGGFGKCPGSSSITFTGNSFVKYR 3868

  Fly  1026 PLQLCQESHLSLEFITRV----ADGLILY-NGPIVPPKPEETVISDFIALELEQGYPRLLIDFGS 1085
            .|:  .|:.|.::...|:    :..:::| .|            :|:..||:..|..:...|.||
Mouse  3869 LLE--NENRLEMKLSMRLRTYSSHAVVMYARG------------TDYSILEIHTGRLQYKFDCGS 3919

  Fly  1086 GTLELRVKTKKTLDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQIP 1150
            |...:.|::.: ::||.||.:.:..:....::|:|...|                    |.|..|
Mouse  3920 GPGIVSVQSIQ-VNDGQWHAVSLEVEGNYAKLVLDEVHT--------------------ASGTAP 3963

  Fly  1151 PFAESLNLNQPLQLGGLYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNSEHYDLAFPALARNSFP 1215
            ...::|||:..:..||..||   |...:.:.|..:.||.||:.::..|.:...|       |:.|
Mouse  3964 GALKTLNLDNYVFFGGHLRQ---QGTKHGRGAQVASGFRGCMDSIYLNGQELPL-------NNKP 4018

  Fly  1216 -ACPQTDEVCLKTEHTARCW---EHGNCVASLVQAKCHCQPGWMGPGCNVPTIPTTFKAQSYVKF 1276
             |....:|           |   .|| |:.:..: .|...|...|..|| |: ||          
Mouse  4019 RAYAHIEE-----------WVDLSHG-CLLTATE-DCSSSPCQNGGVCN-PS-PT---------- 4058

  Fly  1277 ALSFEPDRFSTQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLLTL 1341
                                  ||...:.|..:                            :.|.
Mouse  4059 ----------------------GGYYCKCSALY----------------------------VGTF 4073

  Fly  1342 TAIAVNDGQWHVIRISRYGSAALMELDGGESRRYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGI 1406
            ..::||....:.   ..||...::: :||                 .:.:..|:|.|.:.:.:..
Mouse  4074 CEVSVNPCSSNP---CLYGGTCMVD-NGG-----------------FVCQCRGLYTGQRCQLSPY 4117

  Fly  1407 KTFEVQSDFQRSCLDDIRLDGKHLPLPPAMNGTQWGQATMARNLERNCPSNRPCSNVICPDPFDC 1471
                        |.||                                    ||.|     ...|
Mouse  4118 ------------CKDD------------------------------------PCKN-----GGTC 4129

  Fly  1472 VDLWNEYECTCSEG----RIMSSDTKGCVDRNECLDLPCLNGATCINLEPRLRYRCICPEGYWGE 1532
            .|..:...|.|..|    |..|       |.:||...||.|||.|.|...  .|.|.|.:.|.|:
Mouse  4130 FDSLDGAVCQCDSGFRGERCQS-------DIDECAGNPCRNGALCENTHG--SYHCNCSQEYRGK 4185

  Fly  1533 NCE------LVQEGQRLKLSMGALGAIFVCLIIILILALIFVLYSRKRKTTKKKKRSGPE----- 1586
            :||      .|.....:.|:.|....:|:..|::|:  ::||| .||..:.|||:::.||     
Mouse  4186 HCEDASPNHYVSTPWNIGLAEGIGIIVFIAGIVLLV--MVFVL-CRKMISRKKKRQAEPEDKRLG 4247

  Fly  1587 --------------------KDVRETV----ISY----EDEGGGEDDMTAFDITPLQ-------- 1615
                                .|:...|    |||    ..:.....|..:|:.:.:.        
Mouse  4248 PTTAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTF 4312

  Fly  1616 IPISAQGGPPDIAACKMPIIYPVMTLLPPGQELNVAYLMEERKQRIDKDN---------NAPPFD 1671
            .|.|..|....:|.|.   :.|.:...||....:.:..:::.....|.|.         :..|.:
Mouse  4313 NPESMHGHRKAVAVCS---VAPNLPPPPPSNSPSDSDSIQKPSWDFDYDAKVVDLDPCLSKKPLE 4374

  Fly  1672 DLRNFTFEGSGSIAE--SLSSLASGTDDEN 1699
            :..:..:....|::|  ||||..|.:.|:|
Mouse  4375 EKPSQPYSARESLSEVQSLSSFQSESCDDN 4404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 28/95 (29%)
Cadherin_repeat 140..248 CDD:206637 36/108 (33%)
Cadherin_repeat 256..359 CDD:206637 32/105 (30%)
Cadherin_repeat 379..481 CDD:206637 28/103 (27%)
Cadherin_repeat 489..586 CDD:206637 32/97 (33%)
Cadherin_repeat 594..703 CDD:206637 23/109 (21%)
Cadherin_repeat 724..801 CDD:206637 17/78 (22%)
EGF_CA 977..1010 CDD:238011 12/34 (35%)
LamG 1013..1198 CDD:238058 42/189 (22%)
EGF_2 <1233..1259 CDD:285248 7/28 (25%)
Laminin_G_2 1293..1428 CDD:280389 16/134 (12%)
EGF_CA 1497..1535 CDD:238011 15/37 (41%)
Cadherin_C 1583..1719 CDD:279398 29/169 (17%)
Fat1XP_006509330.1 Cadherin_repeat 39..145 CDD:206637
Cadherin_repeat 154..253 CDD:206637
Cadherin 278..357 CDD:421759
Cadherin_repeat 372..460 CDD:206637
Cadherin_repeat 468..566 CDD:206637
Cadherin_repeat 576..663 CDD:206637
Cadherin_repeat 725..819 CDD:206637
Cadherin_repeat 827..924 CDD:206637
Cadherin_repeat 933..1017 CDD:206637
Cadherin_repeat 1044..1136 CDD:206637
Cadherin_repeat 1144..1242 CDD:206637
Cadherin_repeat 1251..1346 CDD:206637
Cadherin_repeat 1364..1477 CDD:206637
Cadherin_repeat 1486..1583 CDD:206637
Cadherin_repeat 1591..1687 CDD:206637
Cadherin_repeat 1696..1786 CDD:206637
Cadherin_repeat 1794..1899 CDD:206637
Cadherin_repeat 1909..1995 CDD:206637
Cadherin_repeat 2009..2102 CDD:206637
Cadherin_repeat 2110..2199 CDD:206637
Cadherin_repeat 2212..2304 CDD:206637
Cadherin_repeat 2312..2395 CDD:206637
Cadherin_repeat 2419..2513 CDD:206637
Cadherin_repeat 2521..2617 CDD:206637
Cadherin_repeat 2626..2719 CDD:206637
Cadherin_repeat 2733..2830 CDD:206637
Cadherin_repeat 2838..2938 CDD:206637 3/11 (27%)
Cadherin_repeat 2947..3044 CDD:206637 28/96 (29%)
Cadherin_repeat 3052..3146 CDD:206637 36/108 (33%)
Cadherin_repeat 3154..3251 CDD:206637 33/106 (31%)
Cadherin_repeat 3259..3356 CDD:206637 31/114 (27%)
Cadherin_repeat 3364..3461 CDD:206637 32/97 (33%)
Cadherin_repeat 3470..3561 CDD:206637 23/106 (22%)
Cadherin_repeat 3586..3659 CDD:206637 18/83 (22%)
LamG 3879..4010 CDD:214598 36/166 (22%)
EGF_CA 4041..4075 CDD:238011 12/95 (13%)
EGF_CA 4078..4113 CDD:238011 9/55 (16%)
EGF 4118..4148 CDD:394967 11/70 (16%)
EGF_CA 4152..4188 CDD:238011 15/37 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.