DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and Dsg3

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_085099.2 Gene:Dsg3 / 13512 MGIID:99499 Length:993 Species:Mus musculus


Alignment Length:581 Identity:156/581 - (26%)
Similarity:257/581 - (44%) Gaps:67/581 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 EEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQ 211
            |.:|.:....|.::|:   |..:...|.|.::|.||  |.|....|.::...|||.:...:||::
Mouse    60 EREDNSRRNPIAKITS---DFQKNQKITYRISGVGI--DQPPFGIFVVDPNNGDINITAIVDREE 119

  Fly   212 PNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSA 276
               .|.:..|..|.:..|:.:.....:.|.:.|:|||.|.|.|.|:.|.:.||..:.|.||.::|
Mouse   120 ---TPSFLITCRALNALGQDVERPLILTVKILDVNDNPPIFSQTIFKGEIEENSASNSLVMILNA 181

  Fly   277 VDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAM-- 339
            .|.|:||. .|:|:.:.|   |.:|..|..:|.|...||.::|....||||:...|.:.|...  
Mouse   182 TDADEPNH-MNSKIAFKI---VSQEPAGMSMFLISRNTGEVRTLTSSLDREQISSYHLVVSGADN 242

  Fly   340 DGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKV 404
            ||.||......||::||:||..|...:.::...::|  .|...|.....||..||:.|:.:....
Mouse   243 DGTGLSTQCECSIKIKDVNDNFPVLRESQYSARIEE--NTLNAELLRFQVTDWDEEYTDNWLAVY 305

  Fly   405 VPNSGFGADKFAM---VRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHV 466
            ...||...:.|.:   .|..:|.  ||:::.||||   |....:|.|.|.:|.:.......:|.|
Mouse   306 FFTSGNEGNWFEIETDPRTNEGI--LKVVKALDYE---QVQSMQFSIAVRNKAEFHQSVISQYRV 365

  Fly   467 AYSWVVVKLRDINDNV---PKFDREHIEVSIYEDTKVGTILEQFKATDADQG-GHSKVAYKIVRS 527
            ..:.|.:::.|:.:.:   |......::..:..:..||.||..::|||.|.| ..|.|.|.:.| 
Mouse   366 QSTPVTIQVIDVREGISFRPPSKTFTVQRGVSTNKLVGYILGTYQATDEDTGKAASSVRYVLGR- 429

  Fly   528 TNRKRQFAISDRGA-VSIQRPLDRET----QDRHHIQILAIDDGSPARTATATLTVIVKDVNDNA 587
             |......|..:.| :...:.:||::    ......::||||:.: .:|:|.|:.|.|...|:|.
Mouse   430 -NDGGLLVIDSKTAQIKFVKNIDRDSTFIVNKTISAEVLAIDENT-GKTSTGTIYVEVPSFNENC 492

  Fly   588 PTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGN-GGPFTFRLD--PLASDEIKAGFKVEYDRR 649
            |:...:.|.....:.|  ..|.|...|     ||. .||:|..|:  ||.       ..|.:...
Mouse   493 PSVVLEKKDICTSSPS--VTLSVRTLD-----RGKYTGPYTVSLEEQPLK-------LPVMWTIT 543

  Fly   650 GDNENGVAIISSLRPFDREAQKS-----YAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKM 705
            ..|.....:         :||:.     |.:|:.:|||.........:||:|:...:|..|
Mouse   544 TLNATSALL---------QAQQQVSPGVYNVPVIVKDNQDGLCDTPESLTLTVCQCDDRSM 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 25/100 (25%)
Cadherin_repeat 256..359 CDD:206637 37/104 (36%)
Cadherin_repeat 379..481 CDD:206637 27/104 (26%)
Cadherin_repeat 489..586 CDD:206637 28/102 (27%)
Cadherin_repeat 594..703 CDD:206637 25/116 (22%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
Dsg3NP_085099.2 CA 75..155 CDD:214520 23/87 (26%)
Cadherin_repeat 161..263 CDD:206637 38/105 (36%)
Cadherin 272..375 CDD:278457 27/109 (25%)
Cadherin_repeat 396..491 CDD:206637 28/97 (29%)
Cadherin_C <790..837 CDD:279398
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..876
Desmoglein repeat 1 905..930
Desmoglein repeat 2 931..961
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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