DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and Dsg2

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_031909.2	Gene:	Dsg2 / 13511	MGIID:	1196466	Length:	1122	Species:	Mus musculus

Alignment Length:	1214	Identity:	253/1214 - (20%)
Similarity:	437/1214 - (35%)	Gaps:	307/1214 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 NDNPPVFDRQTY-----RTQIT------EEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGID 183
            |:..| |.:.|:     |..||      |.:|.:....|.:: .:|...::.|.|.|..||:||
Mouse    38 NEGKP-FPKHTHLVRQKRAWITAPVALREGEDLSRKNPIAKI-HSDLAEEKGIKITYKYTGKGI- 99

  Fly   184 PDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDN 248
             ..|....|..:|.||::.:...|||::   .|.:..|.:|.|..|..|....::::.:.|||||
Mouse   100 -TEPPFGIFVFDRNTGELNITSILDREE---TPYFLLTGYALDSRGNNLEKPLELRIKVLDINDN 160

  Fly   249 APQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPE 313
            .|.|.|.::.|::.|...|.:.||.::|.|.||| |:.|||:.|.|   |.:|...:.:|.:..:
Mouse   161 EPVFTQEVFVGSIEELSAAHTLVMKITATDADDP-ETLNAKVSYRI---VSQEPANSHMFYLNKD 221

  Fly   314 TGLIKTAVCCLDRERTPDYSIQVVAMDGGGL---KGTGTA--SIRVKDLNDMPPQFTKDEWVTEV 373
            ||.|.|....||||....||:.|.|.||.|.   |....|  .||:.|:||..|......:...|
Mouse   222 TGEIYTTSFTLDREEHSSYSLTVEARDGNGQITDKPVQQAQVQIRILDVNDNIPVVENKMYEGTV 286

  Fly   374 DETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGAD----KFAMVRNGDG----------- 423
            :|..    ....::.:.|.|.||.             |:|    .|......:|
Mouse   287 EENQ----VNVEVMRIKVTDADEV-------------GSDNWLANFTFASGNEGGYFHIETDTQT 334

  Fly   424 -TGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDR 487
             .|.:.:::.:|||   :.......|.|.:|.........||......:.||::::.:.:
Mouse   335 NEGIVTLVKEVDYE---EMKKLDLSIIVTNKAAFHKSILSKYKATPIPITVKVKNVVEGI----- 391

  Fly   488 EHIEVSI--------YEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNR--KRQFAISDRGAV 542
             |.:.|:        .:.:.:...:..|:..|.|.|..:||.|..|:.|:.  ......|:...|
Mouse   392 -HFKSSVVSFRASEAMDRSSLSRSIGNFQVFDEDTGQAAKVTYVKVQDTDNWVSVDSVTSEIKLV 455

  Fly   543 SIQRPLDRETQD-RHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKK 606
            .|.....|..|: .:..:::||....|.:|.|.|:.:.|:|||||.|......:....:    :.
Mouse   456 KIPDFESRYVQNGTYTAKVVAISKEHPQKTITGTIVITVEDVNDNCPVLVDSVRSVCED----EP 516

  Fly   607 ILEVAAKDPDDRLRGNGGPFTFRL---DPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDRE 668
            .:.|.|:|.|.  ..|..||:|.:   .|..:.:.|.          .::...:::  |:..:|:
Mouse   517 YVNVTAEDLDG--AQNSAPFSFSIIDQPPGTAQKWKI----------THQESTSVL--LQQSERK 567

  Fly   669 AQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDV----------NDNKMQPGSKSV----------- 712
            ..:| .||..|.|:...:......|.:|:.:.          .||.:..|..::
Mouse   568 RGRS-EIPFLISDSQGFSCPERQVLQLTVCECLKGGGCVAAQYDNYVGLGPAAIALMILALLLLL 631

  Fly   713 ------LVYNYQGQSQD-TPI-GRV-----YVND---PDDWDVPDKKYYWEVQEH-QRFKLDTDT 760
                  |:.:..|.::. ||| |.:     :.|:   |:|..||...    |.:| :...:....
Mouse   632 LVPLLLLICHCGGGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSLL----VADHAESSAVRGGV 692

  Fly   761 GILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEA---VQQAGSMRLSHITDEDF 822
            |...::.|..:|....  .|...:|...::..........:||.|   |:.||:     |...:.
Mouse   693 GGAMLKEGMMKGSSSA--SVTKGQHELSEVDGRWEEHRSLLTAGATHHVRTAGT-----IAANEA 750

  Fly   823 VRTWNPVKNQVEPSKLERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQ---- 883
            |||                                     ...||...::    .||.|..
Mouse   751 VRT-------------------------------------RATGSSRDMS----GARGAVAVNEE 774

  Fly   884 --QPYF--KAVRLNGVVQMHREEIEKDVGLNITMVNINECL-----HEGKGKCGSNSCTSKVE-- 937
              :.||  ||...||...:|   :.||            ||     .:.....||..|.|.:|
Mouse   775 FLRSYFTEKAASYNGEDDLH---MAKD------------CLLVYSQEDTASLRGSVGCCSFIEGE 824

  Fly   938 --------LGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNG 994
                    ||.|..|::   ...:|.::|:...                          :|.|..
Mouse   825 LDDLFLDDLGLKFKTLA---EVCLGRKIDLDVD--------------------------IEQRQK 860

  Fly   995 PKCVACPVGYNGPRCQQSTRS----FRGN-GWAWYPPLQLCQESHLSLEFITR------------ 1042
            |...|.....:|...:|:..|    :..| |:....||.......::.|.:|.
Mouse   861 PVREASVSAASGSHYEQAVTSSESAYSSNTGFPAPKPLHEVHTEKVTQEIVTESSVSSRQSQKVV 925

  Fly  1043 -----VADGLILY------NGPIVPP--------KPEETVISDFIALELEQGYPRLLIDFGSGTL 1088
                 ||.|.|:.      .|..|||        :|:..::::.:.....     .|:|......
Mouse   926 PPPDPVASGNIIVTETSYAKGSAVPPSTVLLAPRQPQSLIVTERVYAPTS-----TLVDQHYANE 985

  Fly  1089 ELRVKTKKTL--DDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQIPP 1151
            |..:.|::.:  :.|:...|::....::.:.|:...|.::::. ..|..|.....:..|.||...
Mouse   986 EKVLVTERVIQPNGGIPKPLEVTQHLKDAQYVMVRERESILAP-SSGVQPTLAMPSVAAGGQNVT 1049

  Fly  1152 FAESLNLNQPLQLGGLYRQHFDQTLYNWQYAFSSKGFDGCIRNV 1195
            ..|.: |.....|...|:...:.::.......||.|..|.:.|:
Mouse  1050 VTERI-LTPASTLQSSYQIPSETSITARNTVLSSVGSIGPLPNL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	1/1 (100%)
		Cadherin_repeat	140..248	CDD:206637	32/118 (27%)
		Cadherin_repeat	256..359	CDD:206637	39/107 (36%)
		Cadherin_repeat	379..481	CDD:206637	19/117 (16%)
		Cadherin_repeat	489..586	CDD:206637	26/107 (24%)
		Cadherin_repeat	594..703	CDD:206637	19/121 (16%)
		Cadherin_repeat	724..801	CDD:206637	16/86 (19%)
		EGF_CA	977..1010	CDD:238011	5/32 (16%)
		LamG	1013..1198	CDD:238058	38/221 (17%)
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Dsg2	NP_031909.2	Cadherin_repeat	67..160	CDD:206637	27/98 (28%)
		Cadherin_repeat	168..273	CDD:206637	40/108 (37%)
		Cadherin_repeat	282..387	CDD:206637	21/124 (17%)
		Cadherin_repeat	414..500	CDD:206637	24/85 (28%)
		Desmoglein repeat 1	885..916		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	913..932		0/18 (0%)
		Desmoglein repeat 2	917..945		4/27 (15%)
		Desmoglein repeat 3	946..971		5/24 (21%)
		Desmoglein repeat 4	972..995		4/27 (15%)
		Desmoglein repeat 5	996..1024		4/27 (15%)
		Desmoglein repeat 6	1025..1055		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1089..1122		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000