DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and Dsc1

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001278733.1 Gene:Dsc1 / 13505 MGIID:109173 Length:886 Species:Mus musculus


Alignment Length:644 Identity:167/644 - (25%)
Similarity:284/644 - (44%) Gaps:85/644 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 GVIYVASPLDYETRPR-YELRLEATRNRKNNYTTVVINVRDV------NDNPPVFDRQTYR---- 142
            |.||....|...:..| :.:.|...:.::.....||::.|:.      :...||.:|...|    
Mouse    75 GTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEV
VLSAREKKVFRKRHTKEPVHNRSKRRWAPI 139

  Fly   143 -TQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKP 206
             ..:.|......|:.|.|:   ..|..:...|.|.::|.|:|.: |.| .|.|.:.||||:..:.
Mouse   140 PCSLMENSLGPFPQHIQQI---QSDAAQNYTIFYSISGPGVDKE-PYN-LFYIEKDTGDIYCTRS 199

  Fly   207 LDRDQPNGRPQWRFTVFAQDEGGEGLVGYA-----DIQVNLKDINDNAPQFPQGIYFGNVTENGT 266
            :||:|.:     :|.|:......:   |||     .:...::|.|||||.|...:...:|.||..
Mouse   200 IDREQYD-----QFLVYGYATTAD---GYAPDYPLPLLFKVE
DDNDNAPYFETKLTVFSVPENCR 256

  Fly   267 AGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPD 331
            :|:||..::|:|.|:|. :.:.:|.|.|.:.:.::...   |.|.|:||:|.|....||||:...
Mouse   257 SGTSVGQVTAIDKDEPG-TLHTRLKYKILQQIPDQPKH---FSIHPDTGVITTTTPLLDREKCDT 317

  Fly   332 YSIQVVAMDGG----GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQ 392
            |.:.:...|.|    ||..|||.:|.::|.||..|.||:..:.|||:|..    .:..||.:.|.
Mouse   318 YKLVMEVRDMGGQPFGLFTTGTITISLEDENDN
SPYFTQTSYTTEVEENR----IDVEILRMVVH 378

  Fly   393 DEDETNT----FQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQV--- 450
            |:|..||    ..|.::..:..|..|.....| ...|.|.:::||:||...|.:     :|:   
Mouse   379 DQDLPNTPHSKAVYTILKGNENGNFKITTDPN-TNEGVLCVVKPLNYEVSRQVT-----LQIGVL 437

  Fly   451 NDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQG 515
            |:........:....:..:.|.||::| .|..|:.......:...:....|..|..:||.|.:..
Mouse   438 NEAQFTNAANAQPPTMCTTTVTVKI
KD-RDEGPECQPPVKVIQSKDGLPAGQELLGYKAVDPETS 501

  Fly   516 GHSKVAYKIVRSTNRKRQFAISD-RGAVSIQRPLDRETQ----DRHHIQILAIDDGSPARTATAT 575
            ....:.|::|  .:....|.|:. .|.:...:.||||::    ::::|.::|.|  :..|:.|.|
Mouse   502 SGEGLRYEMV--GDEDNWFEINKITGDLRTVKVLDRESKFVKNNQYNISVVATD--TAGRSCTGT 562

  Fly   576 LTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKA 640
            |.|:::|.||:.|..  |.:.|:.:......:||....|..|    ||.||.|.||..:|     
Mouse   563 LVVLLE
DFNDHPPQI--DKEVTICQQEKDFAVLEPIDLDGPD----NGPPFQFLLDNSSS----- 616

  Fly   641 GFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGD 699
              |:......|.:..:     ||.........|::||:|:|.  ...:....|:|.:.|
Mouse   617 --KLWTLESQDGKRAI-----LRQRHNLNYNYYSVPIQIQDR--HGFSAKHVLSVRVCD 666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 9/49 (18%)
Cadherin_repeat 140..248 CDD:206637 29/117 (25%)
Cadherin_repeat 256..359 CDD:206637 34/106 (32%)
Cadherin_repeat 379..481 CDD:206637 24/108 (22%)
Cadherin_repeat 489..586 CDD:206637 24/101 (24%)
Cadherin_repeat 594..703 CDD:206637 25/106 (24%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
Dsc1NP_001278733.1 Cadherin_pro 29..109 CDD:214999 6/33 (18%)
Cadherin 139..233 CDD:278457 26/106 (25%)
Cadherin_repeat 248..350 CDD:206637 35/105 (33%)
Cadherin 359..462 CDD:278457 26/112 (23%)
Cadherin 477..568 CDD:278457 22/94 (23%)
Cadherin_C <837..880 CDD:279398
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 69 1.000 Domainoid score I9567
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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