Protein Alignment CadN2 and ds

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: XP_061514261.1
• Gene: ds / 1278050
• VectorBaseID: AGAMI1_006399
• Length: 3489
• Species: Anopheles gambiae
• Alignment Length: 1241
• Identity: 301/1241 - (24%)
• Similarity: 511/1241 - (41%)
• Gaps: 267/1241 - (21%)

  Fly    20 KFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTN--IRYQI--TGGNIGN 80
            |.:.:.:.|.||:.|.|::.:|...:.|.||..::|:.|.|.|.:|..|  |.|.:  |.....:
Mosquito   466 KDIFLTVTDINDNAPEFEKDVYHANVMEVADPGTSVIQVTAVDRDEGNNSAIVYSLLDTPDTHSH 530

  Fly    81 AFAVQNTTGVIYVASPLDYETRPRYELRLEATRNRK---NNYTTVVINVRDVNDNPPVFDRQTYR 142
            .|.:.:.:|:|...:.:|.||.|..:|.:.|..|.:   ::..||::.:.|||||.|:||:..|.
Mosquito   531 WFQIDSHSGLITTRAHIDCETDPVPQLIVMAQDNGRPPLSSTGTVLVTIHDVNDNEPIFDQSFYN 595

  Fly   143 TQITEEDDRNLPKRILQVTATDGDVDRPIN-IVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKP 206
            ..:.|.:.:.  :.||:|:|||.|..  :| :|.:..|:|.    ..|::|:|..:||::.:...
Mosquito   596 VSVAENESKG--RCILKVSATDPDCG--VNAMVNYTLGEGY----KKNAEFEIRPSTGEVCIASE 652

  Fly   207 LDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTE----NGTA 267
            ||.:..|   .:.|.:.|.|.|  ||...|.:::.|.|:|||.|.|....|..::.|    |...
Mosquito   653 LDYETRN---SYEFPIIATDRG--GLSTTAMVKIQLTDVNDNRPTFYPREYNVSLRESMPTNSLL 712

  Fly   268 GSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETG-LIKTAVCCLDRERTPD 331
            .:.|:.:.|.|.|..:..|   :.|.|   |...|.|  ||.::..|| :..|....|.....|.
Mosquito   713 STPVVVVVATDSDSGSFGT---ISYRI---VAGNEAG--IFRMDRLTGEIFVTRPNMLSSRTQPY 769

  Fly   332 YSIQVVAMDGGGLKGTGTAS--IRVKDLNDMPPQFTKDEWVTEVDETNGTYIPE-----TPILTV 389
            :.:.:.|.|||||:.|..|.  |.|.|....||.|.|..:.        .|:.|     |.:.||
Mosquito   770 HRLNISASDGGGLRSTHDAEVFISVIDATQRPPIFDKPRYT--------YYVKEDVKRNTVVGTV 826

  Fly   390 TVQDEDETNT-----FQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQ 449
            :....:..|.     |.|...|:..|..|..        :|::::...||:|...|       :.
Mosquito   827 SATSSNSGNRGSLRYFIYSGDPDGFFAIDPV--------SGNIRVANALDHETKPQ-------VL 876

  Fly   450 VNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQ 514
            :|.:...|    |.....::.|.:.:.|:|||.|:|:...:.:|:.|:.::|:.|.:..|.|.|.
Mosquito   877 LNIQATSG----DPPAYGHTQVNIDIEDVNDNPPEFESNTVRISVPENVEIGSPLYEANAQDKDS 937

  Fly   515 GGHSKVAYKIVRSTN-----RKRQFAISDR-GAVSIQRPLDRETQDRHHIQILAIDDGSPARTAT 573
            |....:.|.:....|     |...|::..| |.:::.||||.|:..||.:.:.|.|.|:|:.:..
Mosquito   938 GMSGVITYMLAGQGNTLSGARSSLFSMDSRSGHLTLARPLDYESMQRHTLVVTASDSGTPSLSTN 1002

  Fly   574 ATLTVIVKDVNDNAPTFAQ-DYKPTLPENV-SGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASD 636
            .|:.|.|:|||||||.|.: :|..::.|:. |..:||:|:|.|.|   .||....|:::  |..|
Mosquito  1003 LTILVEVQDVNDNAPIFEKNEYAISVIESTPSNSQILQVSATDAD---TGNNARLTYKI--LGED 1062

  Fly   637 EIKAGFKVEYDRRGDNENGVAIISSLRP----------FDREAQKSYAIPIEIKDNGAPAMTGTS 691
            ..:.|   :..:....:..||.|..:.|          .|||.::.|.|.:.:.|||.|.:|.|:
Mosquito  1063 HQRTG---KSTQPASPDEPVAEIFGIFPNSGWIYLRTKLDREVKERYNITVIVSDNGVPTLTATA 1124

  Fly   692 TLTVTIGDVNDNKMQP-GSKSVLVYNY-QGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRF 754
            .:.|||.|.|||  .| .:||:..:.. :...:...||.|..:| .|..:.....|..:..:..|
Mosquito  1125 HVIVTILDANDN--SPIFAKSLYEFEIEENMRRGAMIGTVSASD-SDAGINAVVRYSLIPSNTSF 1186

  Fly   755 KLDTDTGILTMRAGTRR---GRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSH 816
            :::..:|.:|.|....|   ..|.|..:..|:.........::.|.:.|:...|         ..
Mosquito  1187 QINPVSGEITTRDSLDRETKASYDLVVEARDQGTPYRSSRVSVKVQILDVNDNA---------PD 1242

  Fly   817 ITD--EDF--VRTWNPVKNQ-VEPSKLERFRNKLAELLYT-----DRDNVDVFS-------VQLK 864
            |.|  ||.  ||...|:..: |:...::|...:.|.:.|:     |.|...:||       ::.|
Mosquito  1243 IVDPQEDVVSVREEQPIGTEVVKVRAIDRDHGQNASISYSILKGRDSDGYGMFSIDPMSGVIRTK 1307

  Fly   865 EGSPYPLTDVHFAARSATQ--QPYFKAVRL-----------------NGVVQMHREEI------- 903
            ....:....::..|.:||.  :|..:.|||                 :.:|...||::
Mosquito  1308 TSLDHEEKTIYRLAVAATDNGKPPKQTVRLLRIEVLDLNDNRPTFTSSSLVFRLREDVGVGHIIG 1372

  Fly   904 ----------------EKDVGLNITMVNINECLHEG-------KGKC------------------ 927
                            ..|:.:..|:..:...:.||       .||.
Mosquito  1373 SISGNEQSDAENFISSSSDLHITYTLTPLTNDITEGAFDIDRNSGKLVVARQLDREQQSEYRMEI 1437

  Fly   928 -----------GSNSCTSKVELG----------KKPYTVSVNRTALVGVRLDISAQCVCRARNFT 971
                       .|::.|.|:|:.          ..|..|.|:....||..:          .|||
Mosquito  1438 RALDTSASNNPQSSAVTVKIEIADVNDNPPKWPSDPINVYVSEDTPVGAIV----------YNFT 1492

  Fly   972 HQDHNCRT------------HLCYNGGRCVETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWY 1024
            .||::..|            ||.......:::..|...:..|:.:      :.|:.|       .
Mosquito  1493 VQDNDTGTNAEIKYNLSKPAHLAQKEYFAIDSLTGSLTLLAPLDH------EDTQEF-------L 1544

  Fly  1025 PPLQLCQESHLSLEFITRVADGLILY-----NGP--IVPPKPEETV-ISDFIALELEQGYPRLL- 1080
            ..:|...:|....|.:|..|...|:.     |.|  ::|...:..| |||  :||::|....::
Mosquito  1545 LIVQATDQSSNVTERLTTSATARIIVTDVNDNSPKFVIPQAADGVVYISD--SLEIDQVVSHVVA 1607

  Fly  1081 IDFGSG 1086
            ||..||
Mosquito  1608 IDPDSG 1613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	28/97 (29%)
		Cadherin_repeat	140..248	CDD:206637	31/108 (29%)
		Cadherin_repeat	256..359	CDD:206637	31/109 (28%)
		CA	388..483	CDD:214520	21/99 (21%)
		Cadherin_repeat	489..586	CDD:206637	31/102 (30%)
		Cadherin_repeat	594..703	CDD:206637	35/119 (29%)
		EGF_CA	977..1010	CDD:238011	5/44 (11%)
		LamG	1013..1198	CDD:238058	22/83 (27%)
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
ds	XP_061514261.1	None