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Protein Alignment CadN2 and Cdh5

DIOPT Version :10

Sequence 1:	NP_609855.3	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_033998.2	Gene:	Cdh5 / 12562	MGIID:	105057	Length:	784	Species:	Mus musculus

Alignment Length:	838	Identity:	214/838 - (25%)
Similarity:	342/838 - (40%)	Gaps:	208/838 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 DNP---PVFDRQT-----YRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNP 187
            |.|   |...||.     .:..|.||.:.:||..:.::.:   :|:|. |..|.|.|:.
Mouse    32 DTPNMLPAHHRQKRDWIWNQMHIDEEKNESLPHYVGKIKS---NVNRQ-NAKYVLQGEF------ 86

  Fly   188 ANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEG-GEGLVGYADIQVNLKDINDNAPQ 251
            |...|.::..||::...:.|||::.:   ::..|....|:. .:.|...:...|.:.|||||.|.
Mouse    87 AGKIFGVDANTGNVLAYERLDREKVS---EYFLTALIVDKNTNKNLEQPSSFTVKVHDINDNWPV 148

  Fly   252 FPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGL 316
            |...::..:|.|....|:||:.::|||.|||..:.:|.::|.|.|       |...|.|: .:||
Mouse   149 FSHQVFNASVPEMSAIGTSVIRVTAVDADDPTVAGHATVLYQIVK-------GNEYFSID-NSGL 205

  Fly   317 IKTAVCCLDRERTPDYSIQVVAMDGGGLK---GTGTASIRVKDLNDMPPQFTKDEWVTEVDETNG 378
            |.|.:..||||:..:|.|.|...|..||:   ||.|..||::|:||..|.||:..:...|.|...
Mouse   206 IFTKIKNLDREKQAEYKIVVETQDALGLRGESGTATVMIRLEDINDNFPVFTQSTYTFSVPEDIR 270

  Fly   379 TYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAM----VRNGDGTGSLKIIQPLDYEDPL 439
            ...| ...|||...||.:....:|.::  .|...|.|.:    .||   .|.:|..:.||||...
Mouse   271 VGKP-LGFLTVVDPDEPQNRMTKYSIM--QGEYRDTFTIETDPKRN---EGIIKPTKSLDYEVIQ 329

  Fly   440 QSSGFRFRIQVND-----KGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTK 499
            |   :.|.|:..|     :......|.:|     :.|.:.:.|: |..|.|.|......:.|:.|
Mouse   330 Q---YTFYIEATDPTIRYEYLSSTSGKNK-----AMVTINVLDV-DEPPVFQRHFYHFKLPENQK 385

  Fly   500 ---VGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQIL 561
               :||::    |.|.|:...| :.|.|.::::|.:.|.|:.:|.:..::.|||||...:::.:.
Mouse   386 KPLIGTVV----AKDPDKAQRS-IGYSIRKTSDRGQFFRITKQGNIYNEKELDRETYAWYNLTVE 445

  Fly   562 A--IDD-GSP-ARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVS-GKKILEVAAKDPDDRLRG 621
            |  :|. |:| .:.:...:.:.|.|.|||.|.|||.|:|.:.||.: ||.:::::|.|.|
Mouse   446 ANELDSRGNPVGKESIVQVYIEVLDENDNPPEFAQPYEPKVCENAAQGKLVVQISATDKD----- 505

  Fly   622 NGGPFTFRLDPLASDEIKAGFKVE---YDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNG 683
                    :.|: :.:.|...|.|   :....:::|...|......|:||..|.:.:|:.|.|||
Mouse   506 --------VVPV-NPKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHAKFHYLPVLISDNG 561

  Fly   684 APAMTGTSTLTVTIGDVNDN---------KMQPG------------------------------- 708
            .|::||||||||.:...|:.         ..|.|
Mouse   562 VPSLTGTSTLTVGVCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITVITLLIILRRRIRK 626

  Fly   709 -----SKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVP-----------------DKK--YYWEVQ 749
                 |||.|..:.|..:.|...|...  |...:||.                 |.:  .|.:||
Mouse   627 QAHAHSKSALEIHEQLVTYDEEGGGEM--DTTSYDVSVLNSVRGGSTKPLRSTMDARPAVYTQVQ 689

  Fly   750 EHQRFKLDTDTGILTMRAGTRRGRYQLRFKV---------------YDREH-----GQEDIPANL 794
            :..|           :..|...|..::...:               ||..|     |.|.|
Mouse   690 KPPR-----------LAPGLHGGPREMATMIDVKKEEADNDGGGPPYDTLHIYGYEGAESI---- 739

  Fly   795 SVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLYTD 852
                    ||::....:.......|.||:..|.|           ||: .||||..:|
Mouse   740 --------AESLSSLSTNSSDSDIDYDFLNDWGP-----------RFK-MLAELYGSD 777

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.