DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Cdh4

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_033997.1	Gene:	Cdh4 / 12561	MGIID:	99218	Length:	913	Species:	Mus musculus

Alignment Length:	839	Identity:	213/839 - (25%)
Similarity:	340/839 - (40%)	Gaps:	197/839 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFL 177
            |.:|.::....|||.:.:..|                   .|::::::.:   |.|..|.|.|.:
Mouse   162 RRQKRDWVIPPINVPENSRGP-------------------FPQQLVRIRS---DKDNDIPIRYSI 204

  Fly   178 TGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNL 242
            ||.|  .|.|....|:|:..:|.::|.:|:||::   |..:.....|.|..|..:....|:.:.:
Mouse   205 TGVG--ADQPPMEVFNIDSMSGRMYVTRPMDREE---RASYHLRAHAVDMNGNKVENPIDLYIYV 264

  Fly   243 KDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP- 306
            .|:|||.|:|...:|.|:|.|....|:.|||::|.|.||   ||.|..:  :...::.:...:|
Mouse   265 IDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADD---STTANGM--VRYRIVTQTPQSPS 324

  Fly   307 --IFEIEPETGLIKTAVCCLDRERTPDYS--IQVVAMDGG---GLKGTGTASIRVKDLNDMPPQF 364
              :|.|..|||.|.|....||||:...|:  :|...|:|.   ||..|.||.|.|.|:||.||:|
Mouse   325 QNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEF 389

  Fly   365 TKDEWVTEVDETNGTYIPETPILTVTVQDEDETNT----FQYKVVPNSGFGADKFAMVRNGDGT- 424
            |...:..||.|..    .||.:..:||.|.|:.::    ..|:::  ||..:..|: ||....|
Mouse   390 TTSTFAGEVPENR----IETVVANLTVMDRDQPHSPNWNAVYRII--SGDPSGHFS-VRTDPVTN 447

  Fly   425 -GSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDRE 488
             |.:.:::.:|||   .:..|...:.|:::.....|....:. :.:.|.:.:.|:|: .|.|...
Mouse   448 EGMVTVVKAVDYE---LNRAFMLTVMVSNQAPLASGIQMSFQ-STAGVTISVTDVNE-APYFPSN 507

  Fly   489 HIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISD----------RGAVS 543
            |..:.:.|....||.|..|.|.|.|:.....|.|.           .:||          .|.::
Mouse   508 HKLIRLEEGVPAGTALTTFSAVDPDRFMQQAVRYS-----------KLSDPANWLHINTSNGQIT 561

  Fly   544 IQRPLDRET----QDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVS- 603
            ....||||:    .:.:....||.|:|.|..:.|.||.:.:.|:|||||..       ||:...
Mouse   562 TAAILDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPQL-------LPKEAQI 619

  Fly   604 ----GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRP 664
                |...:.:.|.|.|  :..|.||:.|.| |.....::..:.:      ...||.....|||.
Mouse   620 CERPGLNAINITAADAD--MDPNIGPYVFEL-PFIPTTVRKNWTI------TRLNGDYAQLSLRI 675

  Fly   665 FDREAQKSYAIPIEIKDNGAPAMTGTSTLTV------------TIGDVNDNKMQPGS-------- 709
            ...|| ..|.:||.:.|:|.|.::.||.:.|            |:|.|....:..|:
Mouse   676 LYLEA-GVYDVPIIVTDSGNPPLSNTSVIKVKVCPCDENGDCTTVGAVAAAGLGTGAIVAILICI 739

  Fly   710 -----KSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDK--KYYWE--VQEHQRFKL------DTD 759
                 ..:|...:..:.:.....:..:.||:| ||.|.  ||..|  .:|.|.:.|      :..
Mouse   740 VILLIMVLLFVVWMKRREKERHTKQLLIDPED-DVRDNILKYDEEGGGEEDQDYDLSQLQQPEAM 803

  Fly   760 TGILTMRAGTRRGRYQLRFKVYDREHGQE-------------DI-----------------PANL 794
            ..:|:...|.||        |.:|..|.|             ||                 |...
Mouse   804 EHVLSKTPGVRR--------VDERPVGAEPQYPVRPVVPHPGDIGDFINEGLRAADNDPTAPPYD 860

  Fly   795 SVTVRDI-----TAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAEL 848
            |:.|.|.     ||.:|....|.. |...|.|::..|.|           ||: |||::
Mouse   861 SLLVFDYEGSGSTAGSVSSLNSSS-SGDQDYDYLNDWGP-----------RFK-KLADM 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	5/18 (28%)
		Cadherin_repeat	140..248	CDD:206637	25/107 (23%)
		Cadherin_repeat	256..359	CDD:206637	39/110 (35%)
		Cadherin_repeat	379..481	CDD:206637	23/107 (21%)
		Cadherin_repeat	489..586	CDD:206637	28/110 (25%)
		Cadherin_repeat	594..703	CDD:206637	31/125 (25%)
		Cadherin_repeat	724..801	CDD:206637	25/116 (22%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh4	NP_033997.1	Cadherin_pro	30..119	CDD:285913
		E_set	170..270	CDD:298831	29/126 (23%)
		Cadherin_repeat	278..385	CDD:206637	40/111 (36%)
		Cadherin_repeat	393..500	CDD:206637	25/117 (21%)
		Cadherin_repeat	511..608	CDD:206637	27/107 (25%)
		E_set	616..708	CDD:298831	26/101 (26%)
		Cadherin_C	766..908	CDD:279398	40/163 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010