Protein Alignment CadN2 and Cdh2

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_031690.3
• Gene: Cdh2 / 12558
• MGIID: 88355
• Length: 906
• Species: Mus musculus
• Alignment Length: 933
• Identity: 235/933 - (25%)
• Similarity: 381/933 - (40%)
• Gaps: 188/933 - (20%)

  Fly    36 FDRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQITG------GNIGNAFAV-------QNT 87
            |...:|...:.::......:|.|...:.|....::|:.:.      ...|..:||       :..
Mouse    36 FPEDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQA 100

  Fly    88 TGVIYVASPLDYETRPRYELRLEATRN--------RKNNYTTVVINVRDVNDNPPVFDRQTYRTQ 144
            ..:||..   |.||:.::::.:..:|.        ::.:....::..|.:..:.....||.....
Mouse   101 KFLIYAQ---DKETQEKWQVAVNLSREPTLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWV 162

  Fly   145 I----TEEDDRN-LPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVL 204
            |    ..|:.|. .|:.::::.:   |.|:.:::.|.:||.|  .|.|....|.||..:|.:.|.
Mouse   163 IPPINLPENSRGPFPQELVRIRS---DRDKNLSLRYSVTGPG--ADQPPTGIFIINPISGQLSVT 222

  Fly   205 KPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGS 269
            |||||:.   ..::.....|.|..|..:....||.:|:.|:|||.|:|...::.|:|.|....|:
Mouse   223 KPLDREL---IARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGT 284

  Fly   270 SVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP-IFEIEPETGLIKTAVCCLDRERTPDYS 333
            .|||::|:|.|||| :.|..|.|.|....  ..|.:| :|.|..|||.|.|....||||:...|:
Mouse   285 YVMTVTAIDADDPN-ALNGMLRYRILSQA--PSTPSPNMFTINNETGDIITVAAGLDREKVQQYT 346

  Fly   334 --IQVVAMDGG---GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQD 393
              ||...|:|.   ||..|.||.|.|.|:||.||:||...:..||.|.....|    :..:||.|
Mouse   347 LIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVI----VANLTVTD 407

  Fly   394 EDETNT----FQYKVVPNSGFGADKFAMVRN-GDGTGSLKIIQPLDYEDPLQSSGFRFRIQVND- 452
            :|:.:|    ..|::  :.|....:||::.: ....|.:.:::|:|:|   .:..|...:...:
Mouse   408 KDQPHTPAWNAAYRI--SGGDPTGRFAILTDPNSNDGLVTVVKPIDFE---TNRMFVLTVAAENQ 467

  Fly   453 ----KGDDGPGGSDKYHVAYSWVVVKLRDINDNV-----PKFDREHIEVSIYEDTKVGTILEQFK 508
                ||...|..|.      :.|.|.:.|:|:|.     ||..|:.      |....||:|....
Mouse   468 VPLAKGIQHPPQST------ATVSVTVIDVNENPYFAPNPKIIRQE------EGLHAGTMLTTLT 520

  Fly   509 ATDADQGGHSKVAY-KIVRSTNRKRQFAISDRGAVSIQRPLDRET----QDRHHIQILAIDDGSP 568
            |.|.|:.....:.| |:....|..:...::  |.::....||||:    .:.::...||.|:|.|
Mouse   521 AQDPDRYMQQNIRYTKLSDPANWLKIDPVN--GQITTIAVLDRESPNVKNNIYNATFLASDNGIP 583

  Fly   569 ARTATATLTVIVKDVNDNAPTFAQDYKPT--LPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLD 631
            ..:.|.||.:.:.|:|||||........|  .||..|    :.:.|.|.|  :..|.|||.|.|
Mouse   584 PMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNS----INITALDYD--IDPNAGPFAFDL- 641

  Fly   632 PLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVT 696
            ||:...||..:.:      :..||.....:|:....|| ..|.:||.|.|:|.|..:..|.|.|.
Mouse   642 PLSPVTIKRNWTI------NRLNGDFAQLNLKIKFLEA-GIYEVPIIITDSGNPPKSNISILRVK 699

  Fly   697 I------GDVNDNKMQPGS----------------KSVLVYNY----QGQSQDTPIGRVYVNDPD 735
            :      ||..|.....|:                ..:||..:    :.:.::....::.: ||:
Mouse   700 VCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLI-DPE 763

  Fly   736 DWDVPDK--KYYWE--VQEHQRFKL------DTDTGILTMRAGTRR---------GRYQLR---- 777
            | ||.|.  ||..|  .:|.|.:.|      ||.........|.||         .:|.:|
Mouse   764 D-DVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAP 827

  Fly   778 ------------FKVYDREHGQEDIPANLSVTVRDI-----TAEAVQQAGSMRLSHITDEDFVRT 825
                        .|..|.:   ...|...|:.|.|.     ||.::....|.......|.|::..
Mouse   828 HPGDIGDFINEGLKAADND---PTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLND 889

  Fly   826 WNPVKNQVEPSKLERFRNKLAEL 848
            |.|           ||: |||::
Mouse   890 WGP-----------RFK-KLADM 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	15/111 (14%)
		Cadherin_repeat	140..248	CDD:206637	30/112 (27%)
		Cadherin_repeat	256..359	CDD:206637	43/108 (40%)
		CA	388..483	CDD:214520	23/109 (21%)
		Cadherin_repeat	489..586	CDD:206637	25/101 (25%)
		Cadherin_repeat	594..703	CDD:206637	34/116 (29%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
Cdh2	NP_031690.3	Cadherin_pro	31..121	CDD:462590	14/87 (16%)
		CA_like	163..263	CDD:481204	30/107 (28%)
		Cadherin_repeat	273..378	CDD:206637	44/107 (41%)
		Cadherin_repeat	386..494	CDD:206637	26/122 (21%)
		Cadherin_repeat	508..601	CDD:206637	25/94 (27%)
		CA_like	608..701	CDD:481204	32/106 (30%)
		CADH_Y-type_LIR	843..902	CDD:460041	17/73 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..883		3/19 (16%)