DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and Cdh17

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_062727.1	Gene:	Cdh17 / 12557	MGIID:	1095414	Length:	827	Species:	Mus musculus

Alignment Length:	757	Identity:	195/757 - (25%)
Similarity:	304/757 - (40%)	Gaps:	180/757 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNR---KNNYTTVVINVRDVN 130
            :.:::||...| .|.::. .|::|....||.|||..:.|:|.|..:.   .:....:.|.|:|:|
Mouse    57 VTFELTGETDG-IFKIEK-DGLLYHTRALDRETRAVHHLQLAALDSHGAIVDGPVPITIEVKDIN 119

  Fly   131 DNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGD--------------VDRP-IN-IVYF--- 176
            ||.|.|.:..|...:.:......|  .:.|.|||.|              :..| || ::||
Mouse   120 DNRPTFLQSKYEGSVRQNSRPGKP--FMYVNATDLDDPATPNGQLFYQIVIQLPQINDVMYFQID 182

  Fly   177 -------LTGQG---IDP-DNPA------------NSKFDINRTT-------------------- 198
                   ||.:|   :|| .||:            .|:...:.||
Mouse   183 SKTGAISLTPEGSQELDPVKNPSYNLVVSVKDMGGQSENSFSDTTYVDISIRENIWKAPEPVEIR 247

  Fly   199 -----------------------------------------GDIFVLKPLDRDQPNGRPQWRFTV 222
                                                     |:|:|.:.|||::.|...   |..
Mouse   248 ENSTDPHPIKITQVQWNDPGAQYSLVNKEKLSPFPFSIDQEGNIYVTQALDREEKNSHV---FFA 309

  Fly   223 FAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTN 287
            .|:||.|:.|....:|.|.:.|||||.|.....:....|.||...|:|:....|.|.|:.| :.|
Mouse   310 TAKDENGKPLAYPLEIYVKVIDINDNPPTCLSPVTVFEVQENEPLGNSIGIFEAHDMDEAN-NIN 373

  Fly   288 AKLIYSIEKNVIEEETGAP---IFEIEPETGLIKTAVCCLDRERTPDY--SIQVVAMDGGGLKGT 347
            :.|.|.:    :::....|   :|.|....|.::.:...|.::.:|.|  ||:|..:|   .|..
Mouse   374 SILKYKL----VDQTPKVPSDGLFLIGEYEGKVQLSKQSLKKQDSPQYNLSIEVSDVD---FKTL 431

  Fly   348 GTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDE----TNTFQYKVVPNS 408
            ....:.|.|:||..|.|....:.::. .:..|.|..| ||.:...|.||    ::...||:|...
Mouse   432 CYIQVNVIDINDQIPIFETSNYGSKT-LSEDTAIGST-ILIIQATDADEPFTGSSKILYKIVQGD 494

  Fly   409 GFGADKFAMVRN-GDGTGSLKIIQPLDYE-DPLQSSGFRFRIQVND-----KGDDGPGGSDKYHV 466
            ..|  :..:|.: ....|.:||.:|||:| .|:.|..|    |..:     ||.:....|   ..
Mouse   495 TEG--RLEVVTDPTTNAGYVKIKKPLDFETQPVSSIVF----QAENPEPLVKGIEYNASS---FA 550

  Fly   467 AYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRK 531
            ::..:|.   |:|: ||.|.:...:.::.||..||:.:....|.|.:   ...|:|.:  ..|.:
Mouse   551 SFELIVT---DVNE-VPVFPQRIFQANVSEDAAVGSRVGNVTARDPE---GLTVSYSL--KGNMR 606

  Fly   532 RQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYK 595
            ....| |..|.:....||||||:..:.:|::|.:.|..:.::||...:::.|||||.|..|:||.
Mouse   607 GWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGSSLSSTADFHLVLTDVNDNPPRLAKDYT 671

  Fly   596 PTL---PENVSGKKILEVAAKDPDDRLRGNGGPFTFRL--DPLASD-EIKAGFKVEYDRRGDNEN 654
            ...   |.:..|..|.||...|.....|..   |||.|  :.|.|| |:.   |:         |
Mouse   672 GLFFCHPLSAPGSLIFEVTDDDQQSLRRPK---FTFALGREGLQSDWEVS---KI---------N 721

  Fly   655 GVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVT 696
            |.....|.| ..|..::.|.|||.|.|.|.|.|.||..|.||
Mouse   722 GTHARLSTR-HTRFEEQVYNIPIRINDGGQPPMEGTVFLPVT 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	18/65 (28%)
		Cadherin_repeat	140..248	CDD:206637	40/210 (19%)
		Cadherin_repeat	256..359	CDD:206637	26/107 (24%)
		Cadherin_repeat	379..481	CDD:206637	30/112 (27%)
		Cadherin_repeat	489..586	CDD:206637	26/97 (27%)
		Cadherin_repeat	594..703	CDD:206637	36/109 (33%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh17	NP_062727.1	Cadherin_repeat	32..121	CDD:206637	18/65 (28%)
		Cadherin_repeat	130..233	CDD:206637	22/104 (21%)
		Cadherin_repeat	244..335	CDD:206637	18/93 (19%)
		Cadherin_repeat	345..443	CDD:206637	26/105 (25%)
		Cadherin_repeat	457..561	CDD:206637	29/117 (25%)
		Cadherin_repeat	569..662	CDD:206637	26/97 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100