DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Cdh16

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_031689.1	Gene:	Cdh16 / 12556	MGIID:	106671	Length:	830	Species:	Mus musculus

Alignment Length:	709	Identity:	157/709 - (22%)
Similarity:	260/709 - (36%)	Gaps:	186/709 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KIFWVLTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHN----ES 66
            :|.|    ...|||    :.:.|:||..|.|.:.:|..::.:........|.:.|.|.:    .:
Mouse   106 RILW----GPQLVT----VHVKDENDQVPQFSQAIYRAQLSQGTRPGVPFLFLEASDGDAPGTAN 162

  Fly    67 TNIRYQITGGN----IGNAFAVQNTTGVIYV----ASPLDYETRPRYELRLEATRNRKNNYTTVV 123
            :::|:.|...:    :.:.|.:....|.:.:    ::.||:.....|:|               :
Mouse   163 SDLRFHILSQSPPQPLPDMFQLDPHLGALALSPSGSTSLDHALEETYQL---------------L 212

  Fly   124 INVRDVNDNPPVFDR-QTYRTQITEED---------DRNL----PKRILQVTATDGDVDRPINIV 174
            :.|:|:.|.|..... .|....|.|..         ..||    |..|.||..:.|||.
Mouse   213 VQVKDMGDQPSGHQAIATVEISIVENSWAPLEPVHLAENLKVVYPHSIAQVHWSGGDVH------ 271

  Fly   175 YFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQ 239
            |.|..|   |..|    ||:: |.|.:.|...|||:   .:.:::..|.||:..||......::|
Mouse   272 YQLESQ---PPGP----FDVD-TEGMLHVTMELDRE---AQAEYQLQVRAQNSHGEDYAEPLELQ 325

  Fly   240 VNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETG 304
            |.:.|.|||||.........|:.|....|:.:..:||.|.|.|. |.|:.::|.:.....||...
Mouse   326 VVVMDENDNAPVCSPHDPTVNIPELSPPGTEIARLSAEDLDAPG-SPNSHIVYQLLSPEPEEGAE 389

  Fly   305 APIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDLNDMPPQFT 365
            ...||::|.:|.:......|...::  ..:||:|:|    ..||..|...::.|.|:|:..|:|.
Mouse   390 NKAFELDPTSGSVTLGTAPLHAGQS--ILLQVLAVDLAGSESGLSSTCEVTVMVTDVNNHAPEFI 452

  Fly   366 KDEW--VTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGDGTG--- 425
            ..:.  ||..::..    |...:.|:...|.|....|:..          .|| :..||..|
Mouse   453 NSQIGPVTLPEDVK----PGALVATLMATDADLEPAFRLM----------DFA-IEEGDPEGIFD 502

  Fly   426 ----------SLKIIQPLDYE--------------DPLQSSGFRFRIQVNDKGDDGPGGSDKYHV 466
                      .|::.:.|.||              :.|...|            .||..:....:
Mouse   503 LSWEPDSDHVQLRLRKNLSYEAAPDHKVVVVVSNIEELVGPG------------PGPAATATVTI 555

  Fly   467 AYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDA-----------DQGGHSKV 520
            ....||..|        |.|:|..|.||...|..|::|...:.:|.           |..|
Mouse   556 LVERVVAPL--------KLDQESYETSIPVSTPAGSLLLTIQPSDPMSRTLRFSLVNDSEG---- 608

  Fly   521 AYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTV-IVKDVN 584
             :..::..:.:...|.|.:||         :..|.:.:.:.|.|...|..:.:||:.: .:|...
Mouse   609 -WLCIKEVSGEVHTAQSLQGA---------QPGDTYTVLVEAQDTDKPGLSTSATVVIHFLKASP 663

  Fly   585 DNAPTFA-----------QDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDP 632
            ..|.|.:           |||...    |||      .::|||  |....||::|.|.|
Mouse   664 VPALTLSAGPSRHLCTPRQDYGVV----VSG------VSEDPD--LANRNGPYSFALGP 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	14/102 (14%)
		Cadherin_repeat	140..248	CDD:206637	34/120 (28%)
		Cadherin_repeat	256..359	CDD:206637	27/106 (25%)
		Cadherin_repeat	379..481	CDD:206637	21/128 (16%)
		Cadherin_repeat	489..586	CDD:206637	20/108 (19%)
		Cadherin_repeat	594..703	CDD:206637	13/39 (33%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh16	NP_031689.1	CA	<67..126	CDD:214520	8/27 (30%)
		Cadherin_repeat	132..236	CDD:206637	17/118 (14%)
		Cadherin_repeat	246..334	CDD:206637	31/104 (30%)
		Cadherin_repeat	344..447	CDD:206637	28/105 (27%)
		Cadherin_repeat	459..560	CDD:206637	20/127 (16%)
		Cadherin_repeat	570..657	CDD:206637	19/100 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000