DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Cdh1

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_033994.1	Gene:	Cdh1 / 12550	MGIID:	88354	Length:	884	Species:	Mus musculus

Alignment Length:	816	Identity:	211/816 - (25%)
Similarity:	316/816 - (38%)	Gaps:	199/816 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRT 197
            ||:        ...|.:....||.::|:.:   :.|:...:.|.:||||  .|.|....|.|.|.
Mouse   161 PPI--------SCPENEKGEFPKNLVQIKS---NRDKETKVFYSITGQG--ADKPPVGVFIIERE 212

  Fly   198 TGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVT 262
            ||.:.|.:||||:   ...::.....|....||.:....:|.:.:.|.|||.|:|.|.::.|.|.
Mouse   213 TGWLKVTQPLDRE---AIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQPVFEGFVA 274

  Fly   263 ENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP---IFEIEPETGLIKTAVCCL 324
            |....|:|||.:||.|.||...:.||.:.|:|    :.::...|   :|.:..:||:|......|
Mouse   275 EGAVPGTSVMKVSATDADDDVNTYNAAIAYTI----VSQDPELPHKNMFTVNRDTGVISVLTSGL 335

  Fly   325 DRERTPDYSIQVVAMD--GGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPIL 387
            |||..|.|::.|.|.|  |.||..|..|.|.|||:||..|.|....:..:|.|..    ....|.
Mouse   336 DRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENE----VNARIA 396

  Fly   388 TVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD-----------GTGSLKIIQPLDYEDPLQS 441
            |:.|.|:|..||..:|.|         :.:|.:.|           ..|.||..:.||:|...|
Mouse   397 TLKVTDDDAPNTPAWKAV---------YTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQ- 451

  Fly   442 SGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQ 506
                :.:.|..:.::...||  ...:.:.|.|.:.|:|: .|.|......|.:.||..||..:..
Mouse   452 ----YILHVRVENEEPFEGS--LVPSTATVTVDVVDVNE-APIFMPAERRVEVPEDFGVGQEITS 509

  Fly   507 FKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQ-------ILAID 564
            :.|.:.|.....|:.|:|.|.|....:.. .:.||:..:..:|||  |..|::       |:|.|
Mouse   510 YTAREPDTFMDQKITYRIWRDTANWLEIN-PETGAIFTRAEMDRE--DAEHVKNSTYVALIIATD 571

  Fly   565 DGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDP--------DDRLRG 621
            ||||..|.|.||.:::.|||||||         :||    .:.::...::|        |..|..
Mouse   572 DGSPIATGTGTLLLVLLDVNDNAP---------IPE----PRNMQFCQRNPQPHIITILDPDLPP 623

  Fly   622 NGGPFTFRLDPLASDEIKAGFKVEYD----------RRGDNENGVAIISSLRPFDREAQKSYAIP 676
            |..|||..|...||    ..:.:||:          .|.|.|.|                .|.|.
Mouse   624 NTSPFTAELTHGAS----VNWTIEYNDAAQESLILQPRKDLEIG----------------EYKIH 668

  Fly   677 IEIKDNGAPAMTGTSTLTVTI----GDVNDNKMQPGSKSVLVYNYQGQSQDTPIG---------- 727
            :::.||  ......:||.|.:    |.|| |.|:.|..:.      |......:|
Mouse   669 LKLADN--QNKDQVTTLDVHVCDCEGTVN-NCMKAGIVAA------GLQVPAILGILGGILALLI 724

  Fly   728 -----------RVYVND----PDDWDVPDKKYYWEV----QEHQRFKLDTDTGILTMR------- 766
                       |..|.:    ||| |..|..||::.    :|.|.|.|......|..|
Mouse   725 LILLLLLFLRRRTVVKEPLLPPDD-DTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRND 788

  Fly   767 -AGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDIT------------------AEAVQQAGSM 812
             |.|.....|.|.:..:.:.....|..||.....|.|                  |.::....|.
Mouse   789 VAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSS 853

  Fly   813 RLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAEL 848
            ......|.|::..|.           .||: |||::
Mouse   854 ESDQDQDYDYLNEWG-----------NRFK-KLADM 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	28/107 (26%)
		Cadherin_repeat	256..359	CDD:206637	39/107 (36%)
		Cadherin_repeat	379..481	CDD:206637	25/112 (22%)
		Cadherin_repeat	489..586	CDD:206637	33/103 (32%)
		Cadherin_repeat	594..703	CDD:206637	28/130 (22%)
		Cadherin_repeat	724..801	CDD:206637	23/113 (20%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh1	NP_033994.1	Cadherin_pro	29..118	CDD:285913
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..139
		CA_like	160..260	CDD:206635	30/114 (26%)
		Cadherin_repeat	268..373	CDD:206637	40/108 (37%)
		Cadherin	382..461	CDD:278457	21/96 (22%)
		Cadherin	493..575	CDD:278457	24/84 (29%)
		E_set	606..688	CDD:298831	23/103 (22%)
		Cadherin_C	743..879	CDD:279398	32/148 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..808		14/58 (24%)
		Required for binding CTNND1 and PSEN1. /evidence=ECO:0000250	760..771		3/10 (30%)
		Required for binding alpha, beta and gamma catenins. /evidence=ECO:0000250	813..884		15/77 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010