DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Cdh17

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_038965088.1	Gene:	Cdh17 / 117048	RGDID:	619748	Length:	885	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	196/773 - (25%)
Similarity:	324/773 - (41%)	Gaps:	179/773 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNR---KNNYTTVVINVRDVN 130
            :.:::||...| .|.::. .|::|....||.|||..:.|:|.|..::   .:....::|.|:|:|
  Rat    73 VTFELTGETDG-IFKIEK-DGLLYHTRVLDRETRAVHHLQLAALDSQGAIVDGPVPIIIEVKDIN 135

  Fly   131 DNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPI------------------NIVYF- 176
            ||.|.|.:..|...:.:......|  .:.|.||  |:|.|.                  |::||
  Rat   136 DNRPTFLQTKYEGSVRQNSRPGKP--FMYVNAT--DLDDPATPNGQLFYQIVIQLPKINNVMYFQ 196

  Fly   177 ---------LTGQG---IDP-DNP---------------ANSKFD-------------------- 193
                     ||.:|   :|| .||               .||..|
  Rat   197 IDNKTGAISLTPEGSQVLDPIKNPYYNLVVSVKDMGGQNENSFSDTTSVDITVRENIWKAPEPVE 261

  Fly   194 ---------------------------INR-----------TTGDIFVLKPLDRDQPNGRPQWRF 220
                                       ||:           ..|:|:|.:||||::.:...   |
  Rat   262 IRENLTDPHPIKITQVQWNDPGAHYSLINKEKLPQFPFSIDQEGNIYVTQPLDREEKDSHV---F 323

  Fly   221 TVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNES 285
            ...|:||.|:.|....:|:|.:.|||||.|.....:....|.||...|||:...:|.|.|:.| :
  Rat   324 FATAKDENGKPLAYPLEIRVKVIDINDNPPTCLSQVTVFEVQENEVLGSSIGIFAAHDMDEAN-N 387

  Fly   286 TNAKLIYSIEKNVIEEETGAP---IFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGT 347
            .|:.|.|    .::::....|   :|.|:...|.::.....|.::.:|.|::.|...| ...|..
  Rat   388 INSILKY----RLVDQTPKVPSDELFLIDEYGGKVQLGKRSLKKQDSPQYNLTVEVSD-IDFKTL 447

  Fly   348 GTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDE----TNTFQYKVVPNS 408
            .:..:.|.|:||..|.|.:.::.::. .:..|.|..| ||.:...|:||    ::...||:|...
  Rat   448 CSLQVNVIDINDQIPIFERSDYGSKT-LSEDTAIGST-ILIIQATDDDEPFTGSSKILYKIVQGD 510

  Fly   409 GFGADKFAMVRNG-DGTGSLKIIQPLDYE-DPLQSSGFRFRIQVNDKGDDGP----GGSDKYHVA 467
            ..|  :..:|.:. ..||.:||.:|||:| :|:.|..|:         .:.|    .|.:....:
  Rat   511 TEG--RLEVVTDPMTNTGYVKIRKPLDFETEPVTSIVFK---------AENPEPLVNGIEYNASS 564

  Fly   468 YSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKR 532
            ::...:.:.|:|: ||.|.::..:.::.|||.:||.:....|.|.:   ...|:|.:  ..|::.
  Rat   565 FASFELTVTDVNE-VPVFPQQIFQANVSEDTAIGTKVGTVTARDPE---GLTVSYSL--KDNKRG 623

  Fly   533 QFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKP 596
            ...| |..|.:....||||||:..:.:|::|.:.|..:.::||...:::.|||||.|..|:||..
  Rat   624 WLKIDSVTGDIFSTAPLDRETESVYRVQVVATEVGGSSLSSTAYFHLVLMDVNDNPPRLAKDYTG 688

  Fly   597 TL---PENVSGKKILEVAAKDPDDRLRGNGGPFTFRL--DPLASD-EIKAGFKVEYDRRGDNENG 655
            ..   |.:..|..|.|  |.| ||:.......|||.|  :.|.|| |:.   |:         ||
  Rat   689 LFFCHPLSAPGSLIFE--ATD-DDQQSVRRPKFTFALGRESLQSDWEVS---KI---------NG 738

  Fly   656 VAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGD-VNDNKMQPGSKSV 712
            .....|.: ..|..::.|.|||.|.|.|.|.|.|..:|:||... |:.:..:|....|
  Rat   739 THARLSTK-HTRFEEQVYDIPILINDGGQPPMEGIVSLSVTFCQCVDGSCFRPAGNQV 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	18/65 (28%)
		Cadherin_repeat	140..248	CDD:206637	41/212 (19%)
		Cadherin_repeat	256..359	CDD:206637	25/105 (24%)
		Cadherin_repeat	379..481	CDD:206637	28/111 (25%)
		Cadherin_repeat	489..586	CDD:206637	27/97 (28%)
		Cadherin_repeat	594..703	CDD:206637	36/115 (31%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh17	XP_038965088.1	Cadherin_repeat	48..137	CDD:206637	18/65 (28%)
		Cadherin_repeat	146..249	CDD:206637	21/106 (20%)
		Cadherin_repeat	260..351	CDD:206637	20/93 (22%)
		Cadherin_repeat	361..459	CDD:206637	25/103 (24%)
		Cadherin_repeat	473..577	CDD:206637	27/116 (23%)
		Cadherin_repeat	585..678	CDD:206637	27/97 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11139
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100