Protein Alignment CadN2 and Cdh23

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: XP_063134984.1
• Gene: Cdh23 / 114102
• RGDID: 619760
• Length: 3351
• Species: Rattus norvegicus
• Alignment Length: 2009
• Identity: 446/2009 - (22%)
• Similarity: 727/2009 - (36%)
• Gaps: 547/2009 - (27%)

  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNEST--NIRYQITGGNIGNAFAV 84
            |:|.:.::||:.|.|.:.||...:.||..:.::||||.|.|::..|  .:.|..:  :..:.|::
  Rat   444 VKITLINENDNRPIFSQPLYNVSLYENITVGTSVLTVLATDNDVGTFGEVNYFFS--DDPDRFSL 506

  Fly    85 QNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTT--VVINVRDVNDNPPVFDRQTYRTQITE 147
            ...||:|.:.:.||||...|:.|.:.| |:.....||  |.|||.|||||.|.|.:..|...:.|
  Rat   507 DKDTGLIMLIARLDYELIQRFTLTVIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRE 570

  Fly   148 EDDRNLPK--RILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDIN--RTTGDIFVLKPLD 208
                |.|.  :::::.|||.| ..|.|::.:    .|...:...|.|||:  ...|.|.|.:|||
  Rat   571 ----NEPSVTQLVRLRATDED-SPPNNLITY----SIVNASAFGSYFDISVYEGYGVISVSRPLD 626

  Fly   209 RDQ-PNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVM 272
            .:| |||...  .||.|:|.|...|.....:.:.:.|.|||.|.|.:..||.:|.||..||::|:
  Rat   627 YEQIPNGLIY--LTVMAKDAGNPPLYSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 689

  Fly   273 TMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVV 337
            .::|.|.|...|.....:|||:|        |:..|.|...:|.| |....||||...:|.:.|.
  Rat   690 FLNATDLDRSREYGQESIIYSLE--------GSSQFRINARSGEI-TTTSLLDRETKAEYILIVR 745

  Fly   338 AMDGG----GLKGTGTASIRVKDLNDMPPQFTKDE--WVTEVDETNGTYIPETPILTVTVQDED- 395
            |:|||    ...|..|.::.:.|:||..|.: ||.  ::..|:.|.    |::.:.||...|.|
  Rat   746 AVDGGVGHNQKTGIATVNVTLLDINDNHPTW-KDAPYYINLVEMTP----PDSDVTTVVAVDPDL 805

  Fly   396 -ETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQ-PLDYE--DPLQSSGFR-FRIQVNDKGD 455
             |..|..|.:.|     .:||..:.:  .||.::... .||.|  ||:::...| ..:.|.|.|.
  Rat   806 GENGTLVYSIQP-----PNKFYSLNS--TTGKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCGR 863

  Fly   456 DGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKV 520
            .....:..     :.|.|.|.|:|||.|.|........:.|.|..|..:.|..|.|.|:|.:..|
  Rat   864 PPLKATSS-----ATVFVNLLDLNDNDPTFQNLPFVAEVLEGTPAGVSVYQVVAIDLDEGLNGLV 923

  Fly   521 AYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVND 585
            :|::.....|......|..|.|:....||||....:.::::|.|.|:|.:::|:|||:.|.||||
  Rat   924 SYRMQVGMPRMDFVINSTSGVVTTTAELDRERIAEYQLRVVASDAGTPTKSSTSTLTIRVLDVND 988

  Fly   586 NAPT-FAQDYKPTLPENVSGK-KILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDR 648
            ..|| |...|..::.|:|..: :::.:...|.|..|......|      :.:..:...|.|.|..
  Rat   989 ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYF------ITAGNVDGKFSVGYRD 1047

  Fly   649 RGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNG--APAMTGTSTLTVTIGDVNDNKMQPGSKS 711
                    |::.::...|||...:|.:.:|..|||  ....|||:|:.||:.|||||:     ..
  Rat  1048 --------AVVRTVVGLDRETTAAYTLVLEAIDNGPVGKRRTGTATVFVTVLDVNDNR-----PI 1099

  Fly   712 VLVYNYQGQ-SQDTPIGRVYV----NDPDDWDVPDKKYYWEVQEH-QRFKLDTDTGILTMRAGTR 770
            .|..:|:.. .:|.|.|...|    .|.|:.:.....|......| ..|:|...:|:|.
  Rat  1100 FLQSSYEASVPEDIPEGHSIVQLKATDADEGEFGRVWYRILHGNHGNNFRLHVSSGLLV------ 1158

  Fly   771 RGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAV-QQAGSMRLS-----HITDEDFVRTWNPV 829
            ||...|     |||.....:          :.|||. ...|.||.|     ::.|   |....||
  Rat  1159 RGPRPL-----DRERNSSHV----------LMAEAYNHDLGPMRSSVRVIVYVED---VNDEAPV 1205

  Fly   830 KNQVEPSKL-----ERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKA 889
            ..|.:.::|     ......:..:..||||..|        |..     |::...|..:..:
  Rat  1206 FTQQQYNRLGLRETAGIGTSVIVVRATDRDTGD--------GGL-----VNYRILSGAEGKF--- 1254

  Fly   890 VRLNGVVQMHREEIEKDVGLNIT------------MVNINECLHEG-----KGKCG-----SNSC 932
                        ||::..||.:|            ::|::..  :|     :|.|.     .|..
  Rat  1255 ------------EIDESTGLIVTVDYLDYETKTSYLMNVSAT--DGAPPFNQGFCSVYVTLLNEL 1305

  Fly   933 TSKVELGKKPYTVSVNRTALVGVRL-DISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPK 996
            ...|:.....|...:.....:|..: .:.|..:......|::
  Rat  1306 DEAVQFSNASYEAVIMENLALGTEIVRVQAYSIDNLNQITYR----------------------- 1347

  Fly   997 CVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRV--ADGLI------LYNGP 1053
                   ::.....|:...|:                   ::.||.|  ..||:      .|...
  Rat  1348 -------FDAYTSAQAKALFK-------------------IDAITGVITVKGLVDREKGDFYTLT 1386

  Fly  1054 IVP----PKPEETVISDFIALELEQGYPRLLIDFGSGT---------LELRVKTKKTLD------ 1099
            :|.    ||.:.||:. ...|:.....||  .||.|.:         :..||.|.|..|
  Rat  1387 VVADDGGPKVDSTVVY-VTVLDENDNSPR--FDFTSDSAISVPEDCPVGQRVATVKARDPDAGSN 1448

  Fly  1100 ---------DGVWHRLDIFWDTENV----------RMVVDFCRTALVSEMEDGTPPEFDDNACQA 1145
                     ..:....:|....:::          |..:|.....:|:. :.||||...|:..|.
  Rat  1449 GQVVFSLASGNIAGAFEIITSNDSIGEVFVAKPLDREELDHYILKIVAS-DRGTPPRKKDHILQV 1512

  Fly  1146 R----GQIPPFAES---LNLNQPLQLGG----LYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNS 1199
            .    ...||..||   .|::....:||    :..:..|:.:          |.:..:...|...
  Rat  1513 TILDVNDNPPVIESPFGYNVSVNENVGGGTSVVQVRATDRDI----------GINSVLSYYITEG 1567

  Fly  1200 EHYDLAFPALARNS-----FPACPQTDE-------VCLKTEHTARCWEHGNCVASLVQAKCHCQP 1252
            .. |:.| .:.|.|     .||.|..:.       |.::.|.|           ..:.|..|...
  Rat  1568 NE-DMTF-RMDRISGEIATRPAPPDRERQNFYHLVVTVEDEGT-----------PTLSATTHVYV 1619

  Fly  1253 GWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQL-QLRFRTREQG--GELFRVSDQHHREYA 1314
            ..:....|.|..     .|.:.:..|...||..:|.| .::....::|  |.:         .||
  Rat  1620 TIVDENDNAPVF-----QQPHYEVVLDEGPDTVNTSLITVQALDLDEGPNGTV---------TYA 1670

  Fly  1315 ILELRRGHLQFRYNLNSMRNEEQLLTLTA-----IAVNDGQWHVI------------RISRYGSA 1362
            |:   .|::     :|:.|...:...:||     ..::.|::.:|            |::...:.
  Rat  1671 IV---AGNI-----INTFRINRRTGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1727

  Fly  1363 ALMELDGGES-----RRYNESFHFTGHQ-----W--LTIDKQEGVYAGGKAEYTGIKTFEVQSDF 1415
            .:...|..::     |.|...|..|..|     |  |..|:..|  ..|:.||: :...:...:|
  Rat  1728 LVNVNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTFLAHDRDSG--PNGQVEYS-VVDGDPLGEF 1789

  Fly  1416 QRSCLD-------DIRLDGKHLP------------LPPAMNGTQWG--------QATMARNLERN 1453
            ..|.::       |:.||.:.:.            :||..:....|        ...:..||..|
  Rat  1790 VISPVEGVLRVRKDVELDRETIAFYNLTICARDRGVPPLSSTMLVGIRVLDINDNDPVLLNLPMN 1854

  Fly  1454 --CPSNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDT-KGC----------VDRNECLDLP 1505
              ...|.|.|:.:                    ..:::||. .||          .:|.....:.
  Rat  1855 ITISENSPVSSFV--------------------AHVLASDADSGCNALLTFNITAGNRERAFFIN 1899

  Fly  1506 CLNGATCINLEPRLRYRCICPEGYWGENCELVQEGQRLKLSMGALGAIFVCLIIILILALIFVLY 1570
            ...|...:| .|..|.|  .||             .||.:|:
  Rat  1900 ATTGIVTVN-RPLDRER--IPE-------------YRLTVSV----------------------- 1925

  Fly  1571 SRKRKTTKKKKRSGPE------KDVRETVISYEDEGG-------GEDDMTAFDITPLQIPISAQG 1622
                       :..||      ||....::|..||..       |.......:.:|...|::...
  Rat  1926 -----------KDNPENPRIARKDFDLLLVSLADENDNHPLFTEGTYQAEVMENSPAGTPLTVLN 1979

  Fly  1623 GPPDIAACKMPIIYPVMT--LLPPGQEL----NVAYLMEERK-QRIDKDNNAPPFDDLRNFTFEG 1680
            | |.:|......:|.|:|  ||....:|    |...::..|. ..||::..:|||.:|.
  Rat  1980 G-PILALDADEDVYAVVTYQLLGTHSDLFVIDNSTGVVTVRSGVIIDREAFSPPFLELL------ 2037

  Fly  1681 SGSIAESLSSLASGTD-------DENQDF----------NYLQNWGPRFNALAAMYVHDKAKASS 1728
              .:||.:..| :||.       |:|.::          :.|:|..|.|:.|......:.:..:.
  Rat  2038 --LLAEDVGQL-NGTAYLFITILDDNDNWPTFSPPAYTVHLLENCPPGFSVLQITATDEDSGLNG 2099

  Fly  1729 QLPSDGGGGSGDGPGPGASSSSPLGGGGTGGGSGIPGNV-----LAVVATGSGAGPGGG 1782
            :|......|:.|     .....|:.|....|.:.|....     |.||||..|..|..|
  Rat  2100 ELVYRIEAGAQD-----RFLIHPVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSG 2153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	32/94 (34%)
		Cadherin_repeat	140..248	CDD:206637	33/112 (29%)
		Cadherin_repeat	256..359	CDD:206637	35/106 (33%)
		CA	388..483	CDD:214520	28/100 (28%)
		Cadherin_repeat	489..586	CDD:206637	30/96 (31%)
		Cadherin_repeat	594..703	CDD:206637	28/111 (25%)
		EGF_CA	977..1010	CDD:238011	0/32 (0%)
		LamG	1013..1198	CDD:238058	43/241 (18%)
		EGF_2	1233..1259	CDD:400365	2/25 (8%)
		LamG	1265..1426	CDD:238058	35/199 (18%)
		EGF_CA	1497..1535	CDD:238011	8/37 (22%)
		CADH_Y-type_LIR	1662..1719	CDD:460041	17/73 (23%)
Cdh23	XP_063134984.1	None