DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and cdh28

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_017212586.1	Gene:	cdh28 / 108179109	ZFINID:	ZDB-GENE-081104-9	Length:	773	Species:	Danio rerio

Alignment Length:	787	Identity:	193/787 - (24%)
Similarity:	311/787 - (39%)	Gaps:	171/787 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNA-KDH---------- 63
            |...:.:::.|.:..|.|:::...|.|               :|.:|.|.. |||
Zfish     3 VRLGTLFVIFKILSCGFAEESPCTPGF---------------ESKLLVVKVHKDHLHKGERLGRV 52

  Fly    64 -----NESTNIRYQITGGNIGNAFAVQNTTGVI--------------YVASPLDYETRPR-YELR 108
                 :..|.|.:|.|...|.     .|..|.:              :..|..|:..:.. ..:|
Zfish    53 VFSTCDGRTGIDFQSTDQEID-----LNMDGTLMMRRSVTLHEGLKEFSVSAWDFSGKKHTVFVR 112

  Fly   109 LEATRNRKNNYTTVVINVRDVNDN--------------------------PPVFDRQTYRTQITE 147
            :|.....|::....::|...|...                          ||:        .:.|
Zfish   113 VERVDYHKDHDVNTLMNTSSVQTKSLSDDLILIFPKSSLGLNRAKRCWILPPL--------TLHE 169

  Fly   148 EDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQP 212
            ......|.|:.|: .:|...:.|  :.|.:||:|.|.|  ....|.|:|.:|.:.|.:.|||::
Zfish   170 NGKGPFPMRLFQI-KSDSASETP--MAYKITGEGADQD--PKGIFQIDRLSGWVSVTQQLDREK- 228

  Fly   213 NGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAV 277
              :..::....|.......:....:..|.:.|.|||.|.|.|..:..||.|....|...||::|.
Zfish   229 --KASYKLVAHATGVDANIVEKPFEFIVTVMDQNDNKPVFTQNPFNANVPEALEKGEVFMTVTAT 291

  Fly   278 DYDDPNESTNAKLIYSIEKNVIEEETGAP---IFEIEPETGLIKTAVCCLDRERTPDYSIQVVA- 338
            |.||...:.||.:.|:|    |.::..:|   :|.|.|.:|.|......||||:...|::.:.|
Zfish   292 DADDKENTDNADISYAI----ISQDPPSPKPNMFAINPVSGGISMLETGLDREQWSSYTLVITAT 352

  Fly   339 -MDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETN-GTYIPETPILTVTVQDEDETNTF- 400
             |:|.|...||||.|.|.|.|:..|.|.:..:...|.|.. |..:.:.|   ||..||.|:..:
Zfish   353 DMNGEGGSTTGTAVITVTDSNNNAPLFEQTLYTVSVPENQVGAEVAKLP---VTDGDEPESTAWS 414

  Fly   401 -QYKVVPNSGFGADK--FAMVRNGDG--TGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGG 460
             :|:|:     |.||  |..|..|..  .|.:..::||:||...|.  ....|.|||....||
Zfish   415 TKYRVI-----GGDKGGFFNVSTGPSRLEGVITTVKPLNYEKNKQY--ILSVIVVNDDKFVGP-- 470

  Fly   461 SDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIV 525
               ...:.:.|.|.:.|.|: .|:|:.:...:|..||..||:.|..:.|||.|.....|:.|:|
Zfish   471 ---LPTSTATVTVNVEDENE-PPEFNPKEKFISKPEDLPVGSDLVNYTATDPDTEKKQKIIYRI- 530

  Fly   526 RSTNRKRQFAISDRGAVSIQRPLDRET----QDRHHIQILAIDDGSPARTATATLTVIVKDVNDN 586
             ..:.....:::|.|.:.:::|:|||.    ..::...|||:||.....|.|.||.:.::|||||
Zfish   531 -GNDPSGWLSVTDAGQIQVKKPMDRENPSVKDGKYKAVILALDDADTPTTGTGTLVIELQDVNDN 594

  Fly   587 APTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFT--FRLDPLASDEIKAGFKVEYDRR 649
            ||.. .:....|....||..:|.:...|        |.||.  |.::|                :
Zfish   595 APVI-HERTIELCNQDSGPVLLSITDND--------GPPFAGPFTVEP----------------Q 634

  Fly   650 GD---------NENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKM 705
            ||         ||.|..:  ||:|..:..|:.|.:.:.:.|.  ...:..|.:..::.|......
Zfish   635 GDTSKNWSVFFNETGHYL--SLKPQSQLEQREYNLVLRVTDR--EGQSQESAIQASVCDCKGEAF 695

  Fly   706 QPGSKSV 712
            |..:|.|
Zfish   696 QCTNKQV 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	20/121 (17%)
		Cadherin_repeat	140..248	CDD:206637	24/107 (22%)
		Cadherin_repeat	256..359	CDD:206637	37/107 (35%)
		Cadherin_repeat	379..481	CDD:206637	30/107 (28%)
		Cadherin_repeat	489..586	CDD:206637	31/100 (31%)
		Cadherin_repeat	594..703	CDD:206637	23/119 (19%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
cdh28	XP_017212586.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100