DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and LOC103909937

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001315629.1	Gene:	LOC103909937 / 103909937	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	675	Identity:	182/675 - (26%)
Similarity:	296/675 - (43%)	Gaps:	117/675 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 DVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQ---WRFTVFAQDE 227
            |:...:|.:.|...: ||.:.......|||..||::.|.:.:||::..|...   .:|....:|.
Zfish    38 DLGLDVNRLSFRKAR-IDTEGNRKRYCDINLNTGELTVAERIDREEICGDRASCVLKFEFMLEDP 101

  Fly   228 GGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIY 292
                 :....:.:.::|||||:|.|.:.:....:||:...|:.....:|.|.|   ...||...|
Zfish   102 -----LELHRVSLQIQDINDNSPVFSKDLITFEITESTFRGTRYRLNAAHDAD---IGQNAVQRY 158

  Fly   293 SIEKN------VIEEETGAPIFE--IEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGT 349
            |::||      :..:..|....|  :|.|          ||||:..:.::.:.|:|||....:||
Zfish   159 SLQKNDNFQLAINSDVHGEKNLELLLEKE----------LDREQQKEVTLILTAVDGGTPPRSGT 213

  Fly   350 ASIRVK--DLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDE--TNTFQYKVVPNSGF 410
            .:|.|.  |.||..|.|::..:...:.|.:..   :|.::||:..|.||  .....|:....|..
Zfish   214 VAIHVTVLDANDNAPVFSQAVYKVSLPENSPV---DTVVVTVSATDADEGQNGEVMYEFSRISDK 275

  Fly   411 GADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAY-SWVVVK 474
            ....|::.:|   ||.::|...||:||   .:.:..|::          |.|.:.::. :.||:.
Zfish   276 AKKLFSLDKN---TGDIRIAGALDFED---EAVYELRVE----------GKDVFGLSSDAKVVIN 324

  Fly   475 LRDINDNVP----KFDREHIEVSIYEDTKVGTILEQFKATDADQGG------HSKVAYKIVRSTN 529
            |.|:|||.|    |..|..:..|....|:||.|..|.:  |::..|      ...|.:|:|.|.
Zfish   325 LSDVNDNAPEIRLKSLRSPVPESALPGTEVGIINVQDR--DSENNGQVRCSIQQNVPFKLVPSI- 386

  Fly   530 RKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTF-AQD 593
             |..:::...|      .||||....::|.|:|.|:|||..::|..:.:.|.|||||.|.| .|:
Zfish   387 -KNYYSLVTTG------ELDRELLSEYNITIIATDEGSPPLSSTKNIHLTVADVNDNPPVFQQQN 444

  Fly   594 YKPTLPE-NVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVA 657
            |:..:.| |.:|..|..|:|.|||.|..|     |.....|:||...|.........||    ..
Zfish   445 YRAHVQENNKAGSSICSVSATDPDWRQNG-----TVVYSLLSSDVSGAPVSSFLSINGD----TG 500

  Fly   658 IISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQ 722
            :|.::|.||.|..||:.:.:..:|||:|.::...|::|.|.|.|||     |..:|..:.:|.|.
Zfish   501 VIHAVRSFDYEQMKSFKVLVLARDNGSPPLSCNVTVSVFISDENDN-----SPQILYPSPEGNSF 560

  Fly   723 DTP-----------IGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQL 776
            .|.           :.:|...|.|........|:        ....||.|:.|:  |...|..:.
Zfish   561 MTEMVPKAAQARSLVSKVIAVDTDSGQNAWLSYH--------IIKATDPGLFTI--GVHSGEIRT 615

  Fly   777 RFKVYDREHGQED-IPANLSVTVRD 800
            :     |:..:.| :..||.|:|||
Zfish   616 Q-----RDISESDSMKQNLIVSVRD 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	19/84 (23%)
		Cadherin_repeat	256..359	CDD:206637	29/112 (26%)
		Cadherin_repeat	379..481	CDD:206637	25/104 (24%)
		Cadherin_repeat	489..586	CDD:206637	30/102 (29%)
		Cadherin_repeat	594..703	CDD:206637	35/109 (32%)
		Cadherin_repeat	724..801	CDD:206637	19/89 (21%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
LOC103909937	NP_001315629.1	Cadherin_2	18..100	CDD:285466	15/62 (24%)
		Cadherin_repeat	126..226	CDD:206637	30/112 (27%)
		Cadherin_repeat	234..331	CDD:206637	26/115 (23%)
		Cadherin_repeat	344..436	CDD:206637	30/101 (30%)
		Cadherin_repeat	445..546	CDD:206637	35/109 (32%)
		Cadherin_repeat	565..653	CDD:206637	18/86 (21%)
		Cadherin_C_2	673..757	CDD:293101
		Cadherin_tail	793..921	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000