DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and CDH18

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001278885.1	Gene:	CDH18 / 1016	HGNCID:	1757	Length:	790	Species:	Homo sapiens

Alignment Length:	573	Identity:	171/573 - (29%)
Similarity:	266/573 - (46%)	Gaps:	108/573 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 DGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQ--- 225
            ||.|.      |.|||:|      |.:.|.|:.|||||...|.|||:|     :..:.:.||
Human    85 DGSVK------YILTGEG------AGTIFIIDDTTGDIHSTKSLDREQ-----KTHYVLHAQAID 132

  Fly   226 DEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKL 290
            ....:.|...::..:.::|||||||:|..|.|...|.|....|:||:.::|.|.|||....:|::
Human   133 RRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARV 197

  Fly   291 IYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTAS 351
            :|||.:       |.|.|.::|:||:|:||:..:|||....||:.:.|.|    .|||.|:.|.:
Human   198 VYSILQ-------GQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVN 255

  Fly   352 IRVKDLNDMPPQFTKDEWVTEVDETNGTYIPE-----TPILTVTVQDEDETNTFQYKVVPNSGFG 411
            |.:.|:||.||:|.:..:        ..|:||     :.:..:...|.|            :|..
Human   256 ITLTDVNDNPPRFPQKHY--------QLYVPESAQVGSAVGKIKANDAD------------TGSN 300

  Fly   412 ADKFAMVRNGDGTG---------------SLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGS 461
            ||....:.||||.|               |||  :||:||   :...:...|:         |.:
Human   301 ADMTYSIINGDGMGIFSISTDKETREGILSLK--KPLNYE---KKKSYTLNIE---------GAN 351

  Fly   462 DKYHVAYS---------WVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGH 517
            ......:|         .:.:.:.|: |..|.|......:.:||:.|:||::....|.|.| ..:
Human   352 THLDFRFSHLGPFKDATMLKIIVGDV-DEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPD-STN 414

  Fly   518 SKVAYKIVRSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVK 581
            |.|.|.|..:....|.|.| ::.|.:...:.||||....::|.:.|.:..:|...:..|:.:.|.
Human   415 SLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVL 479

  Fly   582 DVNDNAPTFAQDYKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVE 645
            |||||.|..|::|...:.||.. |:.|..::|.|.||  ..||..|.|.||...  .:...|.::
Human   480 DVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDD--FANGPRFNFFLDERL--PVNPNFTLK 540

  Fly   646 YDRRGDNE-NGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI 697
                 ||| |..:|::..|.|.|..|..|.:||.|.|.|.|:::.:||||:.:
Human   541 -----DNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRV 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	27/86 (31%)
		Cadherin_repeat	256..359	CDD:206637	38/106 (36%)
		Cadherin_repeat	379..481	CDD:206637	24/130 (18%)
		Cadherin_repeat	489..586	CDD:206637	28/97 (29%)
		Cadherin_repeat	594..703	CDD:206637	36/106 (34%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
CDH18	NP_001278885.1	CA	79..157	CDD:214520	29/88 (33%)
		Cadherin_repeat	163..264	CDD:206637	39/107 (36%)
		Cadherin_repeat	272..379	CDD:206637	24/141 (17%)
		Cadherin_repeat	387..484	CDD:206637	28/97 (29%)
		Cadherin_repeat	491..589	CDD:206637	36/107 (34%)
		Cadherin_C	637..783	CDD:307269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010