Protein Alignment CadN2 and CDH17

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_001400880.1
• Gene: CDH17 / 1015
• HGNCID: 1756
• Length: 851
• Species: Homo sapiens
• Alignment Length: 734
• Identity: 198/734 - (26%)
• Similarity: 316/734 - (43%)
• Gaps: 122/734 - (16%)

  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNE----STNIRYQIT--GGNIGN 80
            :.|.:.|.||:.|.|.:..||..:.:|:......|.|||.|.::    :..:.|||.  ...|.|
Human   112 ITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPNGQLYYQIVIQLPMINN 176

  Fly    81 A--FAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDV---NDNPPVFDRQT 140
            .  |.:.|.||.|.:......|..|           .||....:||:|:|:   ::|.  |...|
Human   177 VMYFQINNKTGAISLTREGSQELNP-----------AKNPSYNLVISVKDMGGQSENS--FSDTT 228

  Fly   141 YRTQITEEDDRNLPKRILQV-TATDGDVDRPINIV----------YFLTGQGIDPDNPANSKFDI 194
            ....|..|:....||.:..| .:||   ..||.|.          |.|    :|.:......|.|
Human   229 SVDIIVTENIWKAPKPVEMVENSTD---PHPIKITQVRWNDPGAQYSL----VDKEKLPRFPFSI 286

  Fly   195 NRTTGDIFVLKPLDRDQPNG--------RPQ--------WRFTVFAQDEGGEGLVGYADIQVNLK 243
            :: .|||:|.:||||::.:.        |.|        :.|...|:||.|:.|....:|.|.:|
Human   287 DQ-EGDIYVTQPLDREEKDAVSKREEFHRRQDKVLCPSTYVFYAVAKDEYGKPLSYPLEIHVKVK 350

  Fly   244 DINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP-- 306
            |||||.|..|..:....|.||...|:|:.|::|.|.|:.| :.|:.|.|    .::|:....|
Human   351 DINDNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEEN-TANSFLNY----RIVEQTPKLPMD 410

  Fly   307 -IFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEW- 369
             :|.|:...|:::.|...|.::.||.|::.:...| ...|......|.|.|:||..|.|.|.::
Human   411 GLFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSD-KDFKTLCFVQINVIDINDQIPIFEKSDYG 474

  Fly   370 -VTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD---GTGSLKII 430
             :|..::||   |..| |||:...|.||..|...|::.:...|..:..:..:.|   .||.:.|.
Human   475 NLTLAEDTN---IGST-ILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHTNTGYVIIK 535

  Fly   431 QPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHV-AYSWVVVKLRDINDNVPKFDREHIEVSI 494
            :|||:|....|:     |....:..:......||:. :::...:.:.|:|: .|:|.:...:..:
Human   536 KPLDFETAAVSN-----IVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNE-APQFSQHVFQAKV 594

  Fly   495 YEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQR---------PLDR 550
            .||..:||.:....|.|.:   ...::|.:...|          ||.:.|..         ||||
Human   595 SEDVAIGTKVGNVTAKDPE---GLDISYSLRGDT----------RGWLKIDHVTGEIFSVAPLDR 646

  Fly   551 ETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTL---PENVSGKKILEVAA 612
            |....:.:|::|.:.|..:.::.:...:|:.|||||.|..|:||....   |.:..|..|.|  |
Human   647 EAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSAPGSLIFE--A 709

  Fly   613 KDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPI 677
            .|.|..| ..|..|||   .|.|..::..::|      ...||.....|.|..:.| ::.|.:.|
Human   710 TDDDQHL-FRGPHFTF---SLGSGSLQNDWEV------SKINGTHARLSTRHTEFE-EREYVVLI 763

  Fly   678 EIKDNGAPAMTGTSTLTVT 696
            .|.|.|.|.:.|..:|.||
Human   764 RINDGGRPPLEGIVSLPVT 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	26/101 (26%)
		Cadherin_repeat	140..248	CDD:206637	38/134 (28%)
		Cadherin_repeat	256..359	CDD:206637	28/105 (27%)
		CA	388..483	CDD:214520	21/98 (21%)
		Cadherin_repeat	489..586	CDD:206637	23/105 (22%)
		Cadherin_repeat	594..703	CDD:206637	31/106 (29%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
CDH17	NP_001400880.1	Cadherin_repeat	33..122	CDD:206637	3/9 (33%)
		Cadherin_repeat	131..235	CDD:206637	30/116 (26%)
		CA	271..357	CDD:214520	29/90 (32%)
		Cadherin_repeat	365..463	CDD:206637	28/103 (27%)
		Cadherin_repeat	475..581	CDD:206637	27/114 (24%)
		Cadherin_repeat	589..682	CDD:206637	23/105 (22%)
		CA_like	700..784	CDD:481204	29/96 (30%)