DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and CDH12

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001304156.1	Gene:	CDH12 / 1010	HGNCID:	1751	Length:	794	Species:	Homo sapiens

Alignment Length:	551	Identity:	170/551 - (30%)
Similarity:	276/551 - (50%)	Gaps:	61/551 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 DVDRPINIV-YFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQD-EG 228
            |:|:....| |.|:|.|      |.:.|.|:.|||||..::.|||::   :|.:.....|.| |.
Human    81 DLDKGEGTVKYTLSGDG------AGTVFTIDETTGDIHAIRSLDREE---KPFYTLRAQAVDIET 136

  Fly   229 GEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYS 293
            .:.|...::..:.::|||||.|:|..|.|...|.|....|:.|:.:.|.|.|||....:|:::||
Human   137 RKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYS 201

  Fly   294 IEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRV 354
            |.:       |.|.|.|:|:||:|:||:..:|||....|.:.:.|.|.    |||.||...:|.:
Human   202 ILQ-------GQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITL 259

  Fly   355 KDLNDMPPQFTKDEWVTEVDETN--GTYIPETPILTVTVQDED--ETNTFQYKVVPNSGFGADKF 415
            .|:||.||:|.|..:..:|.|::  |:.|..     :...|.|  :....:|.:||  |.|.:.|
Human   260 TDVNDNPPRFPKSIFHLKVPESSPIGSAIGR-----IRAVDPDFGQNAEIEYNIVP--GDGGNLF 317

  Fly   416 AMVRNGD-GTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVA-----YSWVVVK 474
            .:|.:.| ..|.:|:.:|||:|   ....:.|:::.::...|     .::|.|     .:.|.:.
Human   318 DIVTDEDTQEGVIKLKKPLDFE---TKKAYTFKVEASNLHLD-----HRFHSAGPFKDTATVKIS 374

  Fly   475 LRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI-SD 538
            :.|: |..|.|.:....:.:||||.||||:....|.|.|.|. |.|.|.|...::....|.| .:
Human   375 VLDV-DEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGS-SAVRYFIDWKSDGDSYFTIDGN 437

  Fly   539 RGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVS 603
            .|.::....||||:..:::..|:|....:|..|:...:.:.|.|||:..|..:..|:..:.||..
Human   438 EGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAK 502

  Fly   604 GKKILE-VAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLR-PFD 666
            ..:|:: |:|.|.|  |...|..|:|||.|.|:  ||..|.|.     |..|..|.|.:.| .:.
Human   503 PGQIIQIVSAADRD--LSPAGQQFSFRLSPEAA--IKPNFTVR-----DFRNNTAGIETRRNGYS 558

  Fly   667 REAQKSYAIPIEIKDNGAPAMTGTSTLTVTI 697
            |..|:.|.:|:.|:|:..|..:.|:|:|:.:
Human   559 RRQQELYFLPVVIEDSSYPVQSSTNTMTIRV 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	26/83 (31%)
		Cadherin_repeat	256..359	CDD:206637	37/106 (35%)
		Cadherin_repeat	379..481	CDD:206637	23/109 (21%)
		Cadherin_repeat	489..586	CDD:206637	31/97 (32%)
		Cadherin_repeat	594..703	CDD:206637	35/106 (33%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
CDH12	NP_001304156.1	CA	80..158	CDD:214520	28/85 (33%)
		Cadherin_repeat	164..265	CDD:206637	38/107 (36%)
		Cadherin_repeat	273..380	CDD:206637	26/122 (21%)
		Cadherin_repeat	389..484	CDD:206637	30/95 (32%)
		Cadherin_repeat	492..590	CDD:206637	35/107 (33%)
		Cadherin_C	638..785	CDD:307269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010