DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and si:ch73-74h11.1

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_017208205.2	Gene:	si:ch73-74h11.1 / 100534918	ZFINID:	ZDB-GENE-091204-215	Length:	1157	Species:	Danio rerio

Alignment Length:	1111	Identity:	234/1111 - (21%)
Similarity:	368/1111 - (33%)	Gaps:	398/1111 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPIN---IVYFLTGQGID--PDNPANSKF 192
            ||        |::.|..|....:.:.::.:     |:.||   :.|.|||.|.:  |.|    .|
Zfish    37 PP--------TRLYENVDYTKEEYVAKIRS-----DKDINWQVVEYGLTGHGANKLPYN----LF 84

  Fly   193 DINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIY 257
            .||...|.:.|...|||::.:   .:..|..|:...|........:::.::|.|||.|.|.:  .
Zfish    85 VINPENGYVKVTGLLDREKTS---SYNLTGIAKYRNGSIAEENIMLKIKVEDQNDNFPIFRE--Q 144

  Fly   258 FGNVTENGTAGSSVMTMSAVDYDDPNEST-NAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAV 321
            .|:|.|:...|:.||.:.|.|.|:  |.| |:|:.|||.|....|  ...:|.|:..||.:....
Zfish   145 SGSVKESSKIGTPVMQIRATDADE--EGTINSKIAYSIIKQSPAE--SGNMFSIDRATGNVYVKE 205

  Fly   322 CCLDRERTPDYS--IQVVAMDG--GGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIP 382
            ..|||||...|:  :|.|.|||  .|..||||..|.:.|:||..|...|:|:...|||.    :.
Zfish   206 KILDRERHDKYTLIVQGVDMDGHPSGNTGTGTVHINILDINDNVPTLEKEEYSGSVDEG----VV 266

  Fly   383 ETPILTVTVQDED-----------------ETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKII 430
            :..::.:..||:|                 |.|.|..:..|.:              ..|.||:|
Zfish   267 DVVVMRIKAQDKDLKFTDNWLAVFDILKGNEDNLFSIETDPKT--------------NEGILKLI 317

  Fly   431 QPLDYEDPLQ-------------SSGFRFRIQVN-DKG--------------------------- 454
            :|:|:|...:             .:|....:.|| |||
Zfish   318 KPVDFEKVKELDLNLVISNVAPFINGSALELDVNLDKGGAGAGAGAGVGAGLGVGLGVGLGLGLD 382

  Fly   455 ---DDGP--------------------------------------------------GGS----- 461
               |.||                                                  ||.
Zfish   383 AGLDAGPNAGLGAGLDLGAGLDAGLDAELDAGLDAGLDAGLDAGLDAGVDLGAGMDAGGDVGLKP 447

  Fly   462 ----------------------------------------DKYHVAYSW-VVVKLRDINDNVPKF 485
                                                    ||......: |.:.:.::.|. |.|
Zfish   448 GVNPGAKPGPSLGVKPGPKPGPKPGTKPGTSPSGKPVSDPDKKPAGKGYPVKISVNNLPDG-PGF 511

  Fly   486 DREHIEVSIYEDTK--VGTILEQFKATDADQGGHSK-VAYKIVRSTNRKRQFAISDRGA-VSIQR 546
            .....:..:.||..  ...:|..|.|.|.|.|..:: |.|  .:..:......|.:..| :.:.:
Zfish   512 SPSVKDFPVSEDPNEDFPVVLGTFAALDGDTGEPAENVRY--AKGHDPDNWITIDEETAEIKLTK 574

  Fly   547 PLDRETQ----DRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKI 607
            ..|||::    ..:..:|:.:....||:|||.|:.:.|:|.||:.||....|..|...|    |:
Zfish   575 APDRESKFLVNGTYFAKIICMTQDVPAKTATGTIALKVEDTNDHCPTLTSCYHQTCDNN----KV 635

  Fly   608 LEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKA-------GFKVEY------------------D 647
            :.|.|.|.|  ...|..||.|.|  :..:.:..       |..|.:                  |
Zfish   636 VNVTAFDED--ADPNATPFQFAL--IEEESVGKWQMVPINGTTVSFHTQETLWPGIYELTVKITD 696

  Fly   648 RRG----DNENGVAII------SSLRPFDREAQKSYAIPIEIKDNGAPA----MTGTSTLTVT-- 696
            .:|    ||:.....:      ||..| ...||:|  :|::|   |.||    ::|.:.|.:.
Zfish   697 AQGLACPDNQKFEVEVCSCEEKSSCGP-RLAAQRS--VPLKI---GKPALGLFLSGAALLLLVPF 755

  Fly   697 ------IGDVNDNKMQP-GSKSVLV-YNYQGQSQDTPIGRVYVNDPDDWDVP---------DKKY 744
                  .|.||:....| .:|..|: |:.:|      ||       :|.::|         |:|.
Zfish   756 LLLFCQCGTVNEFTDLPFDAKEYLIPYHTEG------IG-------EDKEIPALSGLAATIDQKQ 807

  Fly   745 YWEVQE-----HQRFKLDTDTGIL---------------------TMRAGTRRGR--YQLRF--- 778
            ..:|..     |.:..:..|:.:|                     |:.....|..  |...|
Zfish   808 LLQVSNTVSKMHFQTSVANDSRMLNQDINNDGLTESDGRIWYRENTISTANHRNSALYSASFIQE 872

  Fly   779 -----------KVYDREH-GQEDIPANLSVTVRD--ITAEAVQQ---AGSMRLSHITDED----- 821
                       .|:..|: .|:...|..:..:.|  :..|.|.|   |||:....|.:.|
Zfish   873 KQDIYGDMALGDVFLNEYFSQKASSAAANPPLADGLLVYEYVGQGSPAGSLGCCSILESDDDLEF 937

  Fly   822 ----------FVRTWNPVKNQVEPSKLERFRNKLAELLYTDRDNVDVFSVQLKEGSPYP------ 870
                      .....||.|..:.|:|.|:. .|..|..|....:|...::|:.:....|
Zfish   938 LNNLGSKFLTLAEICNPPKPSLPPTKTEQV-VKSVETSYKSESSVSTSTIQVTKEKTAPQQVQQS 1001

  Fly   871 -LTDVHFAARSAT-----------QQPYFKAVRLNGVVQMHREEIEKDVGLNITMVNINE----- 918
             :|.|......||           |||.|..|.    .||......:.....:.::|.|.
Zfish  1002 SVTKVETVNTFATLPTASQTVYVEQQPLFYFVE----EQMPNISFVESPTQGLFVINGNHGMEGL 1062

  Fly   919 CLHEGK 924
            .|.:||
Zfish  1063 ILQDGK 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	26/112 (23%)
		Cadherin_repeat	256..359	CDD:206637	40/107 (37%)
		Cadherin_repeat	379..481	CDD:206637	28/258 (11%)
		Cadherin_repeat	489..586	CDD:206637	25/104 (24%)
		Cadherin_repeat	594..703	CDD:206637	35/155 (23%)
		Cadherin_repeat	724..801	CDD:206637	19/130 (15%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
si:ch73-74h11.1	XP_017208205.2	CA	58..139	CDD:214520	25/92 (27%)
		Cadherin_repeat	143..248	CDD:206637	41/110 (37%)
		E_set	271..336	CDD:324323	14/78 (18%)
		Cadherin_repeat	526..618	CDD:206637	23/93 (25%)
		E_set	634..699	CDD:324323	13/68 (19%)
		Cadherin_C	<902..951	CDD:307269	9/48 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000