Protein Alignment CadN2 and LOC100494953

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: XP_031759339.1
• Gene: LOC100494953 / 100494953
• XenbaseID: XB-GENE-29082483
• Length: 2999
• Species: Xenopus tropicalis
• Alignment Length: 1823
• Identity: 622/1823 - (34%)
• Similarity: 916/1823 - (50%)
• Gaps: 234/1823 - (12%)

  Fly    19 TKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNA 81
            |.:|||.::|.||:.|.|....|||.::|:.|:...|:||||.|.:|..|  :|||||.||....
 Frog  1300 TAYVRIFVSDVNDNAPRFPMQRYETSVEEDKDVGYVVITVNASDEDEGANAKLRYQITNGNSKGI 1364

  Fly    82 FAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQIT 146
            |.|....|.|::...|:||...::||||.|:..:..|:|.|:|||.::||..|:|.:..:...|.
 Frog  1365 FDVDQEIGAIFITQALNYEQDTQFELRLVASDGKWENHTLVLINVINLNDEVPIFSQTEFHGSIL 1429

  Fly   147 EEDDRNLPKRILQVTATDGDVDRPIN-IVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRD 210
            |. ..:||..:|||:|||.|.:...: :.|.|.|||      |||:|.|::..|.|::.|.|||:
 Frog  1430 EA-ITDLPVYVLQVSATDPDQEADQSALQYSLHGQG------ANSEFIIDQFNGKIYIQKELDRE 1487

  Fly   211 QPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQF---PQGIYFGNVTENGTAGSSVM 272
            |   |..|||.|.|.||.||||.|:||:.:::||:|||.|.|   ..|.:.|.:.||..|.::||
 Frog  1488 Q---RATWRFLVLATDENGEGLTGFADVIIDVKDVNDNEPTFLCTTDGCFMGYIPENSPADTTVM 1549

  Fly   273 TMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVV 337
            .|:|.|.|||....||.|.|.|.:|| :.|....:|.|.|.||.|.|.:..||||:...|.|.|.
 Frog  1550 EMTAFDLDDPKSGRNALLTYRIVQNV-QNEINLNLFAIHPSTGSIYTVLGSLDREKNDKYLIVVE 1613

  Fly   338 AMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQY 402
            |.|||||.|||||:|.:.|:||..|.||::.:...|.| |.|...|..:|.....||.|.....:
 Frog  1614 AKDGGGLSGTGTATILISDINDHAPVFTQNVYTAMVPE-NFTINSEVAVLYAWDLDEGENAMMTF 1677

  Fly   403 KVVPNSGFGAD---KFAMVRNG-DGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDK 463
            .::     |.|   ||.:..:. ...|.:::.:.:||| .:....|...::|.|        .|.
 Frog  1678 SII-----GGDDDRKFFIETDKIHKRGIIRLRKKMDYE-RIHERSFNLTVKVED--------MDF 1728

  Fly   464 YHVAYSWVVVKLRDINDNVPKFDREHIE-VSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRS 527
            |.:||  .|:::.|.||:.|.|....:| :|:.||..:||.:....|.|.|.|.:.|.:|.|:.|
 Frog  1729 YSIAY--CVIQVEDSNDHAPVFYPAVLEAISLPEDVSIGTTVVHLSAIDLDSGQNGKFSYHILNS 1791

  Fly   528 TNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQ 592
            ::....|:::..|.|.:...|||||...|::.|||.|.|.||.|.:.::.:|:.|||||||.|..
 Frog  1792 SDVGGLFSVATDGWVVVAGHLDRETLAEHNLVILATDLGEPALTGSTSVLIIIGDVNDNAPEFEA 1856

  Fly   593 DYKPTLPENVSGKKILEV-------AAKDPDDRLRGNGGPFTFRL--DPLASDEIKAGFKVEYDR 648
            .|.|.:.||.....||:|       ..:|.|..:  ||.||.|.|  ||         |.|....
 Frog  1857 QYSPMIWENTESPHILQVNKTSTLLHVRDNDTEV--NGAPFAFSLVHDP---------FNVHDFS 1910

  Fly   649 RGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVL 713
            ..|..||.|||:.||.||||..:.:.:||.|.|:|.|.::.|:|||:.|||:||:....|.....
 Frog  1911 LQDLHNGSAIITVLRSFDREVHQVFYLPILITDSGNPPLSSTNTLTILIGDINDHPHSSGHLDCT 1975

  Fly   714 VYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRF 778
            ||:|:|......:|:|...|.|:|:  .|.||.| .:.:.|.|:..||:|||:.|...|.|:||.
 Frog  1976 VYSYKGILPTVTLGKVPAPDLDEWE--HKMYYLE-GKSRVFSLNEATGLLTMKEGAIPGVYKLRV 2037

  Fly   779 KVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRN 843
            ||.|..  ..|:.:.:.:.|.|||.||...|.|:|:|..|.||||     ::...:.||.|..:.
 Frog  2038 KVSDGT--WPDVISTVRIVVHDITEEAALNAISVRISGFTAEDFV-----LRPPDKISKYELMKY 2095

  Fly   844 KLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHREEIEKDVG 908
            .|.|:|..:.||:.:||| |.........|:.||....|:.   :|.:|||:|...||:||..:|
 Frog  2096 LLLEILQAELDNIHIFSV-LNTPGLSGCMDIWFAVSGDTRH---QAEKLNGIVASSREKIESTLG 2156

  Fly   909 LNITMVNINECLHEGKGKCG-SNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTH 972
            :.:|.:...||.:.   ||. ...|..:....:.|..::....:...|.:...|.|.|.:|.  |
 Frog  2157 VQVTQIGEYECENV---KCSHQTGCLVRSSYKQTPTMITAGSVSFGSVTILTKALCSCPSRE--H 2216

  Fly   973 QDHNCRTH---LCYNGGRCVETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESH 1034
            |..:|.::   .|.|||.||:...|.:| .||:.::||.|||:..:|.|.|:||:||:.||.||.
 Frog  2217 QHLSCSSYERNPCLNGGICVDGNMGYRC-ECPLSFHGPECQQTKHTFIGQGYAWFPPMALCYESQ 2280

  Fly  1035 LSLEFITRVADGLILYNGPIVPPKPEETVISDFIALELEQGYPRLLIDFGSGTLELRVKTKKTLD 1099
            :||:|||...:||:|:|||:.|.|..:|  .|||||||:.|.|.|.|:.|||||.|:..||:.|.
 Frog  2281 ISLDFITEKGNGLLLFNGPMSPSKYRQT--EDFIALELQNGSPLLAINHGSGTLLLQFSTKQNLA 2343

  Fly  1100 DGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQIPPFAESLNLNQPLQL 1164
            |..||.:.|..:.:.|:|::|.|..||.:|.:....|..|.::|:.....|.....|::.|||||
 Frog  2344 DRRWHNIRIESNGKKVKMILDHCSDALANEADGIRQPLHDRSSCEVSTGTPGNKRFLDVYQPLQL 2408

  Fly  1165 GGLYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNSEHYDLAFPALARNSFPACPQTDEVCLKTEH 1229
            ||:  :|...:|:.   |....||.||:||:..:|:.|||..|..:.||.|.|..||.:|..| .
 Frog  2409 GGV--KHVLPSLHP---ALQFSGFIGCLRNLKVDSKVYDLEQPLESLNSIPGCTMTDGLCAVT-G 2467

  Fly  1230 TARCWEHGNCVASLVQAKCHCQPGWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQLQLRFR 1294
            :..|..||.|::.|...:|||.||:.|..|........|:..|::.:.|...|...|..:||..|
 Frog  2468 SPPCGGHGFCISDLSSIRCHCHPGYHGDNCETVLQEWNFEKDSWIHYQLHILPSLHSLSVQLMVR 2532

  Fly  1295 TREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRY 1359
            ||.....:......:...:..||:..|:...|:|..   ..|.|:||.|:.::.|||..:...||
 Frog  2533 TRMASCTILSFVSTNKSSFLRLEVVEGNFAVRFNFG---EREHLITLPALRIDHGQWTSLSFERY 2594

  Fly  1360 GSAALMELDGGESRRYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGI----KTFEVQS------- 1413
            .::                  ||    |.|:|     .||..|.|.:    :.|:|.|
 Frog  2595 DNS------------------FT----LMINK-----GGGDHELTSVMGTSRLFDVDSSSILLGT 2632

  Fly  1414 --------DFQRSCLDDIRLDGKHLPLPPAMNGTQWGQATMARNLERNCPSNRPCSNVICPDPFD 1470
                    ||| .||.||||:|:||||....||  :......:.:.|.|.|: .|.:..|..|.:
 Frog  2633 SLLQGGRNDFQ-GCLRDIRLNGRHLPLDGLENG--YSSTVSVQGVSRGCHSD-ACRSQPCQSPLN 2693

  Fly  1471 CVDLWNEYECTC--SEGRIMSSDT--KGCVDRNECLDLPCLNGATCINLEPRLRYRCICPEGYWG 1531
            |:|||.:|||.|  .|..::::.|  |.|.. :.|:...|.||.||: .:...:|.|.|.:||.|
 Frog  2694 CIDLWRKYECRCPADEVEVINNMTGQKHCYP-SPCMRWSCRNGGTCV-AQSHQKYVCQCRDGYKG 2756

  Fly  1532 ENCELVQ--EGQRLKLSMGALGAIFVCLIIILILALIFVLYSRKRKTTKKKKRSG-----PE--- 1586
            ..||.:|  ..:.:.||.|::.||.:||:|.:.|.:.:.::|  :..:.|..:.|     ||
 Frog  2757 RICESIQINTAKMIGLSSGSILAISMCLLIFIALLVSYTVWS--QWGSSKFHKGGVYHIPPEHES 2819

  Fly  1587 -KDVRETVISYEDEGGGEDDM--------------------TAFDITPLQIPISAQGGPPDIAAC 1630
             :|:||:||::.:|.|.|.:.                    ..:|...|:.|:  :.....:.:.
 Frog  2820 WEDIRESVINFSEESGIEHNQCWKKASKASGEVVHKSTKITNGYDKHKLKRPL--RENVQQLCSS 2882

  Fly  1631 KMPIIYPVMTLLP--------PGQELNVAYLMEERKQRIDKDNNAPPF----------------- 1670
            :..::.|    .|        .|:..|..:    .|.:|..:|..|.|
 Frog  2883 ENDLVLP----RPHQPAEESHTGKSTNATF----HKLQISTENRHPSFQFYVPQMLWAADNDMKS 2939

  Fly  1671 ---DDLRNFTFEGSGSIAESLSSLASGTDDENQDFNY--LQNWGPRFNALAAMYVHDKAKASSQL 1730
               |.|.::|.||.||...|||||.|.:.||  ||||  ||.||.:|:.|..:|         :.
 Frog  2940 HPPDLLHSYTTEGQGSPTGSLSSLDSSSTDE--DFNYDVLQEWGSKFDRLKELY---------RS 2993

  Fly  1731 PSD 1733
            |||
 Frog  2994 PSD 2996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	39/92 (42%)
		Cadherin_repeat	140..248	CDD:206637	46/108 (43%)
		Cadherin_repeat	256..359	CDD:206637	47/102 (46%)
		CA	388..483	CDD:214520	22/98 (22%)
		Cadherin_repeat	489..586	CDD:206637	35/97 (36%)
		Cadherin_repeat	594..703	CDD:206637	45/117 (38%)
		EGF_CA	977..1010	CDD:238011	13/35 (37%)
		LamG	1013..1198	CDD:238058	77/184 (42%)
		EGF_2	1233..1259	CDD:400365	11/25 (44%)
		LamG	1265..1426	CDD:238058	45/179 (25%)
		EGF_CA	1497..1535	CDD:238011	12/37 (32%)
		CADH_Y-type_LIR	1662..1719	CDD:460041	28/78 (36%)
LOC100494953	XP_031759339.1	PHA03247	<51..374	CDD:223021
		Cadherin_repeat	475..564	CDD:206637
		Cadherin_repeat	575..667	CDD:206637
		Cadherin_repeat	681..769	CDD:206637
		Cadherin_repeat	778..877	CDD:206637
		Cadherin_repeat	890..986	CDD:206637
		Cadherin_repeat	995..1083	CDD:206637
		Cadherin_repeat	1095..1198	CDD:206637
		Cadherin_repeat	1207..1313	CDD:206637	6/12 (50%)
		Cadherin_repeat	1322..1414	CDD:206637	38/91 (42%)
		Cadherin_repeat	1423..1522	CDD:206637	46/108 (43%)
		Cadherin_repeat	1537..1636	CDD:206637	47/99 (47%)
		Cadherin_repeat	1644..1744	CDD:206637	27/116 (23%)
		Cadherin_repeat	1756..1850	CDD:206637	34/93 (37%)
		Cadherin_repeat	1857..1965	CDD:206637	45/118 (38%)
		EGF_CA	2221..2256	CDD:238011	13/35 (37%)
		LamG	2261..2437	CDD:238058	77/182 (42%)
		EGF_CA	<2470..2498	CDD:238011	11/27 (41%)
		LamG	2526..2654	CDD:214598	41/158 (26%)
		EGF_CA	<2732..2760	CDD:238011	11/28 (39%)
		CADH_Y-type_LIR	2933..2991	CDD:460041	25/59 (42%)