DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and LOC100492690

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:XP_031750532.1 Gene:LOC100492690 / 100492690 XenbaseID:XB-GENE-29081299 Length:904 Species:Xenopus tropicalis


Alignment Length:869 Identity:197/869 - (22%)
Similarity:326/869 - (37%) Gaps:232/869 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 QITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLD 208
            :|.||.....||.|..|...||     ..:.|.|.|:||:.:  ....|.||...|:|:|...:|
 Frog    67 EIQEELPGPYPKLIGTVNMEDG-----AQLRYKLQGKGINEE--PKGLFHINEDNGNIYVHDKVD 124

  Fly   209 RDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMT 273
            .:.   .|.:.:...|.::....|.....||:.:.|||||||:|....|...|.|:...|.:|.|
 Frog   125 FEV---TPVFHWEFHAINKTSNKLGTKLGIQLKVIDINDNAPEFSSSSYEVPVNESCMQGFTVFT 186

  Fly   274 MSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP--IFEIEPETGLIKTAVCCLDRERTPDYSIQV 336
            :.|.|.|| :.|.|:.:.|::    :.:....|  .|.:..|.|.| :...|||..|..:|.:|.
 Frog   187 LLAYDKDD-HSSPNSLVHYTL----LSQTPADPDVEFTVHKEKGFI-SFKGCLDYARNKNYKLQF 245

  Fly   337 VAMDGGGL---KGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETN 398
            .|.|.|..   :......|.:.|.|:.||.:...|..||:.|..|    ...::.:.|.|:|...
 Frog   246 EAKDNGAAIQQRNQCEMIINIIDGNNNPPIWANGEGPTEIPEREG----NRTVIRLAVTDKDTPF 306

  Fly   399 TFQYKVVPNSGFGADKFAMVR-NGDGT-----------GSLKIIQPLDYE--------------D 437
            |..::.|         ::::. |.||.           |.|.:|:|||||              :
 Frog   307 TPAWRAV---------YSIIEGNEDGNFKIETDPVTNEGILTVIKPLDYETSSQNNLSITVANQE 362

  Fly   438 PLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVV------------------VKLRDINDNVPK 484
            ||      |..:|.::...|           .|||                  ||::|:|| .|:
 Frog   363 PL------FSCKVVERTPFG-----------LWVVDAAKKIKAKTLTPMKGVNVKVKDVND-PPQ 409

  Fly   485 FDREHIEVSIYEDT-KVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAIS-DRGAVSIQRP 547
            |..|.:..::.|.: |.|:.:.:.:|.|.|....:|:.|.|:  .:.....|:: |.|.::..:.
 Frog   410 FVSEKVGYNVVEHSLKPGSPVGRIQAKDMDIISPNKIKYVIL--NDPAHWVAVNEDTGVITCTQD 472

  Fly   548 LDRETQ----DRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKIL 608
            :|||::    .::::.|||:|||.|:.|:|.|..:.:||:|||.||....|..............
 Frog   473 MDRESEFVSNSKYNVTILAVDDGVPSMTSTVTFIINLKDINDNTPTLESPYMSICESEEEALMST 537

  Fly   609 EVAAKDPDDRLRGNGGPFTFR-LDPLASDEIKAGFKVEYDRRGDNENGVAIIS-----------S 661
            .:..:|.|.    ..|||... ||       ||..|.......:|:|.:.::.           .
 Frog   538 PIIDRDLDP----YSGPFYIEALD-------KATEKKHLKLMENNDNVLKVLKLKDAPRGNHTLR 591

  Fly   662 LRPFDRE---AQKSYAIPI-EI--------KDNGAPAMTGTST------------LTVTIGDVND 702
            |..:||:   :|:::.:.: |.        |.|..|.|.|.:.            |::.:..:..
 Frog   592 LEIYDRQGVISQQNFTVFVCECLEGGVCLEKMNDPPTMGGGAIALLLLPPVLFLGLSLLLCKIQR 656

  Fly   703 NKM-----QPGSKSVLVYNYQGQSQDTPIG-RVYVNDPD--DWDVPD------------------ 741
            .|:     |....|::.||.:..:.|.... .|..|.|:  ...|.|                  
 Frog   657 VKVMVPVEQEPLHSMIAYNEESGTMDCQASPSVLDNSPNLVGQGVKDEGGTAAAAAEEEIDSVFH 721

  Fly   742 ----KKY-------------------YWEVQEHQRFKLDTDTGILTMRA-------GTRR-GRYQ 775
                :||                   .::.|..|..:..|.|.|..:.|       |.|| ..:.
 Frog   722 RASTRKYSAPALMMEQKMMLARSSNQQYQFQRQQSLRQTTVTSIKRVSARRHSSFHGERRASNHM 786

  Fly   776 LRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNP------------ 828
            ||...   ..||....|..|.:.|...::.::.....:|....|.| :.|..|            
 Frog   787 LRQMA---AAGQRRSSATNSSSARSYHSKILENVIKQKLDSHVDYD-LATPKPRVYALEGDLSPA 847

  Fly   829 --------VKNQVEPSKLERFRNK 844
                    ..:.::|.:||...:|
 Frog   848 PSLEALSIASSCIDPERLENLGSK 871

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 29/103 (28%)
Cadherin_repeat 256..359 CDD:206637 29/107 (27%)
CA 388..483 CDD:214520 29/138 (21%)
Cadherin_repeat 489..586 CDD:206637 28/102 (27%)
Cadherin_repeat 594..703 CDD:206637 24/144 (17%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
LOC100492690XP_031750532.1 Cadherin_repeat 66..161 CDD:206637 29/103 (28%)
Cadherin_repeat 169..>251 CDD:206637 26/87 (30%)
Cadherin 284..361 CDD:394985 19/89 (21%)
Cadherin_repeat 423..515 CDD:206637 27/93 (29%)
CADH_Y-type_LIR 826..880 CDD:460041 8/47 (17%)
Blue background indicates that the domain is not in the aligned region.

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