DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and cdh12

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:XP_017950450.2 Gene:cdh12 / 100489783 XenbaseID:XB-GENE-982876 Length:826 Species:Xenopus tropicalis


Alignment Length:782 Identity:201/782 - (25%)
Similarity:337/782 - (43%) Gaps:162/782 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 DVDRPI-NIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQD-EG 228
            |:|:.| ::.|.|.|.|      |.:.|.|:.|||||..:|.|||::   :|.:.....|.| ..
 Frog   114 DLDKGIGSVKYTLLGDG------AGTIFTIDDTTGDIHAIKSLDREE---KPFYTLRAQAVDIVT 169

  Fly   229 GEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYS 293
            |:.:...::..:.::|||||.|:|..|.|..:|.|....|:.|:.:.|.|.|||...::|:::||
 Frog   170 GKPVEPESEFIIKVQDINDNEPKFLDGPYVASVPEMSPVGAYVLQVKATDADDPTYGSSARVVYS 234

  Fly   294 IEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRV 354
            |.:       |.|.|.|:|:||:|:||:..:|||....|.:.:.|.|.    |||.||.|.:|.:
 Frog   235 ILQ-------GQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTTVNITL 292

  Fly   355 KDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDED--ETNTFQYKVVPNSGFGADKFAM 417
            .|:||.||:|.|..:..:|.|.:..   .:||..:...|.|  .....:|.:||  |.|.:.|. 
 Frog   293 TDVNDNPPRFPKSIFHLKVPEASPV---GSPIGKIRAVDPDFGRNAEIEYSIVP--GDGGNLFD- 351

  Fly   418 VRNGDGT--GSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDIND 480
            ::..|.|  |.:.:|:|||:|   ....:.|:::..:...|....|.......:.|.:.:.|: |
 Frog   352 IKTDDDTQEGIIFLIKPLDFE---TKKAYTFKVEATNVHLDHRFNSVGPFKDIATVKINVLDV-D 412

  Fly   481 NVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI-SDRGAVSI 544
            ..|.|.:....:.:||||..|||:....|.|.|. |.|.:.|.|...|:....|.: ::.|.|:.
 Frog   413 EPPVFSKPFYTMEVYEDTPTGTIIGAVTAQDLDI-GTSPIQYSIDAQTDADNNFVVDANEGTVAT 476

  Fly   545 QRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILE 609
            ...||||:..:.:|.|:|....:|...:...:.:.|.|:|:..|.....|:.::.||....:|::
 Frog   477 NALLDRESTAQFNISIIASKVNNPQLASLVKIIINVLDINEFPPEVYLPYETSVCENAKPGQIIQ 541

  Fly   610 -VAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLR-PFDREAQKS 672
             :.|.|.|  :...|..|:||..|.:|  ....|.:.     |.:|..|.|.:.: .:.|..::.
 Frog   542 IIGAVDRD--MSPAGQIFSFRQPPDSS--ANPNFTIH-----DYKNNTAGIQAQKHGYSRRQKEF 597

  Fly   673 YAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQDTPIGR--------- 728
            |.:|:.::|:..|..:.|||||:.:       .:..||.| |.:...::...|:|.         
 Frog   598 YLLPVVVEDSSYPIQSSTSTLTIRV-------CRCDSKGV-VLSCNVEAIFLPVGLSTGALIAIL 654

  Fly   729 -----------VYV-------ND---PDDWDVPDKKYYWE-----VQEHQRFKLDTDTGILTMRA 767
                       :||       .|   ....|:.|...:::     .::.|.|    |.|.|.   
 Frog   655 LCIIILLVIVVLYVALRRQKKKDALMTSKEDIRDNVIHYDDEGGGEEDTQAF----DIGALR--- 712

  Fly   768 GTRRGRYQLRFKVYDREHGQEDI------------PANLSVTVRDITAEAVQQ------------ 808
                     ..||.:....:.||            |:..:..:||...|.:|:            
 Frog   713 ---------NPKVIEEHKVRRDIKPEHLCLPRQKPPSEFNTDIRDFINEKLQEHDADPNAPPYDS 768

  Fly   809 --------AGSM--RLSHITDE--------DFVRTWNPVKNQVEPSKLERFRNKLAELLYTDRDN 855
                    .||:  .||.|..:        ||:..|.|           .|:: |||:...:..|
 Frog   769 LATYAYEGTGSVAETLSSIESQNMEMEQEYDFLSDWGP-----------HFKS-LAEMFGKENYN 821

  Fly   856 VD 857
            :|
 Frog   822 LD 823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 26/83 (31%)
Cadherin_repeat 256..359 CDD:206637 38/106 (36%)
CA 388..483 CDD:214520 22/98 (22%)
Cadherin_repeat 489..586 CDD:206637 29/97 (30%)
Cadherin_repeat 594..703 CDD:206637 28/110 (25%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
cdh12XP_017950450.2 CA 113..191 CDD:214520 28/85 (33%)
Cadherin_repeat 197..298 CDD:206637 39/107 (36%)
Cadherin_repeat 306..413 CDD:206637 25/116 (22%)
Cadherin_repeat 422..517 CDD:206637 28/95 (29%)
Cadherin_repeat 525..623 CDD:206637 28/113 (25%)
CADH_Y-type_LIR 757..816 CDD:460041 13/70 (19%)
Blue background indicates that the domain is not in the aligned region.

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