Protein Alignment CadN2 and cdh3

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: XP_002936044.2
• Gene: cdh3 / 100485633
• XenbaseID: XB-GENE-482277
• Length: 881
• Species: Xenopus tropicalis
• Alignment Length: 943
• Identity: 234/943 - (24%)
• Similarity: 363/943 - (38%)
• Gaps: 237/943 - (25%)

  Fly     8 FWVLTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDH--NESTNIR 70
            |.||.:.|.||.:.|::...|        .:|:..| .|......||.:.|..|.|  .|.::.|
 Frog    80 FRVLPDGTVLVKRHVKLHSKD--------TKFIVST-WDARGIKHSTNIAVVNKRHRSGEESHRR 135

  Fly    71 YQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPV 135
                                   :|.|...|.|.....|   :.:|.::..           ||:
 Frog   136 -----------------------SSELPVLTFPEKRTGL---KRKKRDWVI-----------PPI 163

  Fly   136 FDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGD 200
                    :::|.:....|||::|:.:   :.:|...:.|.:||||  .|.|....|.|.:.||.
 Frog   164 --------KVSENERGPFPKRLVQIKS---NKERVTKVFYSITGQG--ADTPPEGVFRIEKETGW 215

  Fly   201 IFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENG 265
            :.|.:||||::.:   ::.....|..|.|..:....:|.|.:.|.|||.|:|.|.::.|:|.|..
 Frog   216 MLVSRPLDREEYD---KYVLLSHAVSENGASVEEPMEITVYVIDQNDNRPKFTQEVFRGSVREGV 277

  Fly   266 TAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTP 330
            ..|:.||.:||.|.||..|:.|..:.|||.|...|:.| ..:|.|..|||:|......||||:.|
 Frog   278 QPGTRVMAVSATDDDDGIETLNGVISYSILKQDPEQPT-PNLFTINRETGVISLIGTGLDREKFP 341

  Fly   331 DY--SIQVVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQD 393
            :|  ::|...:||.||...|.|.|.:.|.||..|.|....:...|.|:...:  |...|:||..|
 Frog   342 EYILTVQAADLDGAGLSTEGKAIIEITDANDNAPIFDPKTYTALVPESEVGF--EVQRLSVTDLD 404

  Fly   394 EDETNTFQ--YKV-VPNSGFGADKFAMVRNGDGT-GSLKIIQPLDYEDPLQSSGFRFRIQVNDKG 454
            :..|..:|  ||: |...||    |.:..:.|.. |.|...:.||:|   |...:..:|.|.:
 Frog   405 QPGTAAWQAVYKIRVNEGGF----FNITTDPDSNQGILTTAKGLDFE---QRKQYVLQITVEN-- 460

  Fly   455 DDGPGGSDKYHV----AYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQG 515
                  ::.:.|    :.:.|.|.:.|:|: .|.|.....::.:.||...|..:....|.|.|:.
 Frog   461 ------AEPFSVPLPTSTATVTVMVEDVNE-APFFVPVVSKIDVSEDLTRGQQIVSLVAQDPDKQ 518

  Fly   516 GHSKVAYKIVRSTNRKRQFAIS-DRGAVSIQRPLDRETQ----DRHHIQILAIDDGSPARTATAT 575
            ...|::|.|  ..:..|...:: |.|.|:....||||::    :.:.:.:|..|||.|..|.|.|
 Frog   519 QKQKLSYVI--GNDPARWLTVNKDTGIVTGNGNLDRESEYVKNNTYSVIMLVTDDGVPVGTGTGT 581

  Fly   576 LTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDP--------DDRLRGNGGPFTFRLDP 632
            |.:.|.|||||.|             |...::..:..::|        |..:..|..|:...|..
 Frog   582 LILHVLDVNDNGP-------------VPSPRVFTMCDQNPEPQVLTITDADIPPNTYPYNVSLSH 633

  Fly   633 LASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI 697
             .||.|   :|.|.|.:|.:       ..|.|..:..:..|:|.:.:.|     ......|||.
 Frog   634 -GSDLI---WKAELDSKGTS-------MRLSPTQQLKKGDYSIYVLLSD-----AQNNQQLTVV- 681

  Fly   698 GDVNDNKMQPGSKSVLVYNYQGQS----------QDTPIGRVYVND------------------- 733
                         :..|.|.:|::          .|.||..|.:..
 Frog   682 -------------NATVCNCEGKAIKCQEKLVGGFDLPIILVILGSVLALLILFLLLLLFLKRKK 733

  Fly   734 --------PDDWDVPDKKYYWEV----QEHQRFKLDTDTGILTMRAGTRRG----------RYQL 776
                    |:| |..|..:|:..    :|.|.:.|......|..|....|.          .|:.
 Frog   734 VVKEPLLLPED-DTRDNIFYYGEEGGGEEDQDYDLSQLHRGLDSRPDIMRNDVVPTLISAPHYRA 797

  Fly   777 RFKVYDREHGQEDIPANLSVTVRDITA----------------EAVQQAGSMRLSHITDE---DF 822
            |....| |.| ..|..||.....|.||                ||. ...|:..|:..||   ::
 Frog   798 RPSNPD-EIG-NFIEENLDAADNDPTAPPYDSLLVFDYEGSGSEAA-SLSSLNSSNSNDEHNYNY 859

  Fly   823 VRTWNPVKNQVEPSKLERFRNKLAELLYTDRDN 855
            :..|.|           ||| |||::...|.|:
 Frog   860 LNDWGP-----------RFR-KLADMYGGDDDD 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	15/92 (16%)
		Cadherin_repeat	140..248	CDD:206637	29/107 (27%)
		Cadherin_repeat	256..359	CDD:206637	40/104 (38%)
		CA	388..483	CDD:214520	25/102 (25%)
		Cadherin_repeat	489..586	CDD:206637	30/101 (30%)
		Cadherin_repeat	594..703	CDD:206637	21/116 (18%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
cdh3	XP_002936044.2	Cadherin_pro	32..121	CDD:462590	13/49 (27%)
		CA_like	160..260	CDD:481204	31/126 (25%)
		Cadherin_repeat	268..373	CDD:206637	41/105 (39%)
		Cadherin_repeat	381..484	CDD:206637	28/119 (24%)
		Cadherin_repeat	497..592	CDD:206637	30/96 (31%)
		CA_like	607..686	CDD:481204	20/108 (19%)
		CADH_Y-type_LIR	816..875	CDD:460041	17/71 (24%)