DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and CDH6

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_004923.1 Gene:CDH6 / 1004 HGNCID:1765 Length:790 Species:Homo sapiens


Alignment Length:868 Identity:222/868 - (25%)
Similarity:352/868 - (40%) Gaps:229/868 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 VASPLDYETR--PRYELRLEATRNRKN------------------NYTTVVINVRDVNDNPPVFD 137
            :::||...|.  |..:..||.:.|.||                  .||.              .|
Human    20 LSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTG--------------SD 70

  Fly   138 RQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIF 202
            .| |..::..:.||.           ||      ::.|.|:|.|      |...|.||..||||.
Human    71 YQ-YVGKLHSDQDRG-----------DG------SLKYILSGDG------AGDLFIINENTGDIQ 111

  Fly   203 VLKPLDRDQP-------------NGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQ 254
            ..|.|||::.             .|||       .:.|        ::..:.:.|||||.|.|.:
Human   112 ATKRLDREEKPVYILRAQAINRRTGRP-------VEPE--------SEFIIKIHDINDNEPIFTK 161

  Fly   255 GIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKT 319
            .:|...|.|....|:.|:.::|.|.|||....:||::|||.:       |.|.|.:|.|||:|||
Human   162 EVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQ-------GQPYFSVESETGIIKT 219

  Fly   320 AVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTY 380
            |:..:|||....|.:.:.|.|    .|||.||.|.:|.:.|:||.||:|.:..:..:..|::.  
Human   220 ALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSP-- 282

  Fly   381 IPETPILTVTVQDED--ETNTFQYKVVPNSGFGADKFAMVRNGD-GTGSLKIIQPLDYEDPLQSS 442
             |.|||..:...|.|  |....:|.:  ..|.|.|.|.::.:.: ..|.:.:.:.||:|   :..
Human   283 -PGTPIGRIKASDADVGENAEIEYSI--TDGEGLDMFDVITDQETQEGIITVKKLLDFE---KKK 341

  Fly   443 GFRFRIQVNDKGDD------GPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVG 501
            .:..:::.::...:      ||....      :.|.:.:.|: |..|.|.:....:.|.||.::.
Human   342 VYTLKVEASNPYVEPRFLYLGPFKDS------ATVRIVVEDV-DEPPVFSKLAYILQIREDAQIN 399

  Fly   502 TILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDD 565
            |.:....|.|.| ...:.|.|.:.|.|:..|.|.| |..|::...:.|||||...|:|.::|.:.
Human   400 TTIGSVTAQDPD-AARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEI 463

  Fly   566 GSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILE-VAAKDPDDRLRGNGGPFTFR 629
            .:|.:::...|.:.|.|||||||.||:.|:..:.|.....:::: :.|.|.||...|:  .|:|.
Human   464 NNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGH--QFSFS 526

  Fly   630 LDPLASDEIKAGFKVEYDRRGDN-ENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTL 693
            |.|.|:.  .:.|.::     || :|...|::....::|....:|.:|:.|.||..|..:.|.|:
Human   527 LAPEAAS--GSNFTIQ-----DNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTV 584

  Fly   694 TVTI--GDVNDNKMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKL 756
            ||.:  .|.:.| ||......|::         |.|                             
Human   585 TVRVCACDHHGN-MQSCHAEALIH---------PTG----------------------------- 610

  Fly   757 DTDTGIL--------------TMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQ 807
             ..||.|              .:.|..||.|.:....:     .:|||..|: |:..|       
Human   611 -LSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLII-----SKEDIRDNI-VSYND------- 661

  Fly   808 QAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLY------TDRDNVDV---FSVQL 863
            :.|....:...|...:|  ||  ..:|.:||.  |:.:.|.|:      |.|||.||   .:.:|
Human   662 EGGGEEDTQAFDIGTLR--NP--EAIEDNKLR--RDIVPEALFLPRRTPTARDNTDVRDFINQRL 720

  Fly   864 KEGSPYPLTDVHFAARSATQQPY 886
            ||....|           |..||
Human   721 KENDTDP-----------TAPPY 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637 11/58 (19%)
Cadherin_repeat 140..248 CDD:206637 28/120 (23%)
Cadherin_repeat 256..359 CDD:206637 40/106 (38%)
CA 388..483 CDD:214520 17/103 (17%)
Cadherin_repeat 489..586 CDD:206637 30/97 (31%)
Cadherin_repeat 594..703 CDD:206637 29/112 (26%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
CDH6NP_004923.1 CA 79..157 CDD:214520 29/115 (25%)
Cadherin_repeat 163..264 CDD:206637 41/107 (38%)
Cadherin_repeat 272..379 CDD:206637 21/121 (17%)
Cadherin_repeat 388..484 CDD:206637 30/96 (31%)
Cadherin_repeat 492..589 CDD:206637 28/105 (27%)
CADH_Y-type_LIR 723..782 CDD:460041 4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

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