DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN2 and CDH4

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001785.2 Gene:CDH4 / 1002 HGNCID:1763 Length:916 Species:Homo sapiens


Alignment Length:623 Identity:172/623 - (27%)
Similarity:277/623 - (44%) Gaps:103/623 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 RNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFL 177
            |.||.::....|||.:.:..|                   .|::::::.:   |.|..|.|.|.:
Human   165 RRRKRDWVIPPINVPENSRGP-------------------FPQQLVRIRS---DKDNDIPIRYSI 207

  Fly   178 TGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNL 242
            ||.|  .|.|....|.|:..:|.::|.:|:||::   ...:.....|.|..|..:....|:.:.:
Human   208 TGVG--ADQPPMEVFSIDSMSGRMYVTRPMDREE---HASYHLRAHAVDMNGNKVENPIDLYIYV 267

  Fly   243 KDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP- 306
            .|:|||.|:|...:|.|:|.|....|:.|||::|.|.||   ||.|..:  :...::.:...:| 
Human   268 IDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADD---STTANGM--VRYRIVTQTPQSPS 327

  Fly   307 --IFEIEPETGLIKTAVCCLDRERTPDYS--IQVVAMDGG---GLKGTGTASIRVKDLNDMPPQF 364
              :|.|..|||.|.|....||||:...|:  :|...|:|.   ||..|.||.|.|.|:||.||:|
Human   328 QNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEF 392

  Fly   365 TKDEWVTEVDETNGTYIPETPILTVTVQDEDETNT----FQYKVVPNSGFGADKFAMVRNGDGT- 424
            |...:..||.|..    .||.:..:||.|.|:.::    ..|:::  ||..:..|: ||....| 
Human   393 TASTFAGEVPENR----VETVVANLTVMDRDQPHSPNWNAVYRII--SGDPSGHFS-VRTDPVTN 450

  Fly   425 -GSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDRE 488
             |.:.:::.:|||   .:..|...:.|:::.....|....:. :.:.|.:.:.|||: .|.|...
Human   451 EGMVTVVKAVDYE---LNRAFMLTVMVSNQAPLASGIQMSFQ-STAGVTISIMDINE-APYFPSN 510

  Fly   489 HIEVSIYEDTKVGTILEQFKATDADQGGHSKVAY-KI--------VRSTNRKRQFAISDRGAVSI 544
            |..:.:.|....||:|..|.|.|.|:.....|.| |:        :.:||          |.::.
Human   511 HKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATN----------GQITT 565

  Fly   545 QRPLDRET----QDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQD-----YKPTLPE 600
            ...||||:    .:.:....||.|:|.|..:.|.||.:.:.|:|||||.....     .||.|  
Human   566 AAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNL-- 628

  Fly   601 NVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPF 665
                 ..:.:.|.|.|  :..|.||:.|.| |.....::..:.:      ...||.....|||..
Human   629 -----NAINITAADAD--VDPNIGPYVFEL-PFVPAAVRKNWTI------TRLNGDYAQLSLRIL 679

  Fly   666 DREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDN 703
            ..|| ..|.:||.:.|:|.|.::.||.:.|.:...:||
Human   680 YLEA-GMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDN 716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637 6/18 (33%)
Cadherin_repeat 140..248 CDD:206637 24/107 (22%)
Cadherin_repeat 256..359 CDD:206637 39/110 (35%)
CA 388..483 CDD:214520 22/100 (22%)
Cadherin_repeat 489..586 CDD:206637 29/109 (27%)
Cadherin_repeat 594..703 CDD:206637 28/108 (26%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
CDH4NP_001785.2 Cadherin_pro 30..119 CDD:462590
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..168 1/2 (50%)
CA_like 173..273 CDD:481204 28/126 (22%)
Cadherin_repeat 281..388 CDD:206637 40/111 (36%)
Cadherin_repeat 396..503 CDD:206637 26/117 (22%)
Cadherin_repeat 514..611 CDD:206637 28/106 (26%)
CA_like 619..711 CDD:481204 28/108 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 806..838
CADH_Y-type_LIR 853..911 CDD:460041
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.