DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and si:dkey-22o22.2

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:XP_001921123.3 Gene:si:dkey-22o22.2 / 100149950 ZFINID:ZDB-GENE-100922-84 Length:2780 Species:Danio rerio


Alignment Length:1775 Identity:630/1775 - (35%)
Similarity:921/1775 - (51%) Gaps:170/1775 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 TKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNA 81
            |.:||:.:.|.||:.|.|.:.:||..::|:.::...|:||.|.|.:|..|  :|||||.||....
Zfish  1080 TAYVRVFVTDVNDNAPAFSQPVYEISVEEDKEVGFVVITVTANDEDEGANAKLRYQITSGNTMGT 1144

  Fly    82 FAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQIT 146
            |.|:...|.|::|..||||...||||||.|:..:..|.|.|||||.:.||..|:|.:..|...:.
Zfish  1145 FDVEPEVGTIFIAQRLDYEQVQRYELRLVASDGKWENQTMVVINVINQNDEAPLFTQTEYHASVM 1209

  Fly   147 EEDDRNLPKRILQVTATDGDVDRPINIV-YFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRD 210
            || ...||..:|:|:|||.|.:.....| |.|.|||      |.|:|.|:...|.||..:.|||:
Zfish  1210 EE-LTELPVLVLEVSATDPDQEADQRAVRYSLHGQG------AGSEFTIDEINGRIFAQRRLDRE 1267

  Fly   211 QPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQF---PQGIYFGNVTENGTAGSSVM 272
            .   |..|:|.|.|.||.|.||.|:||:.|:::|||||||.|   ....:.|:|.||..|.:|:|
Zfish  1268 V---RSAWQFLVLATDENGAGLTGFADVLVDVQDINDNAPVFLCATDNCFLGHVPENSPADTSIM 1329

  Fly   273 TMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVV 337
            .|.|.|.|||....||.|.|.|.:|| ..|....:|.|.|.||.|.|.:..||||....|.:.|.
Zfish  1330 EMRATDLDDPKAGKNAILTYRIVQNV-RNEINLNLFSINPTTGTIYTVLRSLDREVVDRYLVVVE 1393

  Fly   338 AMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQY 402
            |.|||||.|||||:|.:.|:||.||.||:..::..:.| |.....|..::..|..||.|.:...:
Zfish  1394 ARDGGGLSGTGTATIVISDVNDHPPVFTQRVYMASMSE-NLDINSEVMVVAATDGDEGENSVMTF 1457

  Fly   403 KVVPNSGFGADK----FAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDK 463
            .::     |.|:    |......:..|.:::.:.:|:|.|.:.: |...::|.|        :|.
Zfish  1458 SII-----GGDEDRKFFIETDKVNRRGIVRLKKKIDFEKPHERT-FNLTVKVED--------ADF 1508

  Fly   464 YHVAYSWVVVKLRDINDNVPKFDREHIEV-SIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRS 527
            :.:||  .::::.|.||:.|.|..:..|. |::||..||||:.|..|.|.|.|.:.:..|.|...
Zfish  1509 FSLAY--CIIQVEDSNDHTPVFFPQFYEAGSMFEDVPVGTIVAQVTAMDLDSGQNGRFTYSIAPE 1571

  Fly   528 TNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQ 592
            ::..:||.:...|.|.:...||||...:|.:.|||.|.||||.|.:|.:.|.|:|||||.|.|..
Zfish  1572 SDPFQQFLVDKSGWVVVADSLDREKVAQHRLMILATDMGSPALTGSAIVLVTVQDVNDNGPEFEA 1636

  Fly   593 DYKPTLPENVSGKKILE-------VAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRG 650
            .|:|.:.||....:::.       :.|.|.|  ...|||||:.||..|.||  ...|.:.     
Zfish  1637 PYRPIVWENTIAPQVIHMNDTSTLLHAIDRD--TSSNGGPFSIRLLMLTSD--VTNFNLT----- 1692

  Fly   651 DNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVY 715
            |..||.|:|::||.||||.||.|.:||.:.|:|:|.|:.||||||.|||.||:...||....:||
Zfish  1693 DMRNGSAMITALRSFDREQQKQYLLPILMIDSGSPPMSSTSTLTVIIGDKNDHPHAPGHSEFIVY 1757

  Fly   716 NYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKV 780
            |.||....|.:|:|...|.|||.  :|.|.:|.:..::|.|:.:.|.|::|.||..|.|.|:.:|
Zfish  1758 NIQGTLPTTVLGQVQSPDLDDWS--EKVYKFEGKPPRQFILNQNNGQLSVREGTAAGLYSLQVRV 1820

  Fly   781 YDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKL 845
            .|:  ...|:.::..|||.::..||::.|.|:||:::|..:|.|.     :..|.|:..|.|..|
Zfish  1821 ADK--SWPDVTSSAEVTVMELQEEALRNAASIRLANLTANEFFRA-----SANEESRYMRLRRLL 1878

  Fly   846 AELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHREEIEKDVGLN 910
            :||..||.:||||||:............|.|||..:   ||:|..:|:|.:.||:.::|..:|:.
Zfish  1879 SELFQTDVENVDVFSLASGRQPAQHHLSVWFAAHGS---PYYKPEKLHGYIAMHKAKLESALGVT 1940

  Fly   911 ITMVNINECLHEGKGKCGSNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDH 975
            |..|.::||::...|:.|  .|:|||.....|.|::....:||.|....|.||.|..|...|.  
Zfish  1941 ILQVGVDECVYAACGQTG--GCSSKVTFSDTPTTLNNGNISLVSVSAKASVQCGCLGRESVHL-- 2001

  Fly   976 NCRTHL---CYNGGRCVETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSL 1037
            :|.::.   |.|||.||::..|.:| .||..::||.|||:..||.|||:||:.|::.|.:||:||
Zfish  2002 HCSSYSQSPCLNGGTCVDSELGYRC-KCPPMFDGPECQQTKHSFLGNGYAWFHPIKPCFQSHISL 2065

  Fly  1038 EFITRVADGLILYNGPIVPPKPEETVISDFIALELEQGYPRLLIDFGSGTLELRVKTKKTLDDGV 1102
            ||||..|:||:.||||:..|:|.|.  .|||||||:.|.|.|.::.|||||.|::..:.|:.|..
Zfish  2066 EFITEAANGLLFYNGPMGAPQPREK--EDFIALELKNGVPVLSVNHGSGTLTLQLSARATVTDRR 2128

  Fly  1103 WHRLDIFWDTENVRMVVDFCRTALVSEMED-GTPP-EFDDNACQARGQIPPFAESLNLNQPLQLG 1165
            ||.|||..|.::|:|::|.|..|:|:|:|. |... |.|.:.|:|.|:.|.....|::.||||||
Zfish  2129 WHHLDIISDGKSVQMILDHCSGAVVNEVEGLGVEMFETDQSVCKASGETPGSERFLDVYQPLQLG 2193

  Fly  1166 GLYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNSEHYDLAFPALARNSFPACPQTDEVCLKTEHT 1230
            |:...|..:..:. .|    |||.||:||::.:|:.|||:..|.:.|:.|.|..||.||| |...
Zfish  2194 GVKETHSLRRSHP-HY----KGFVGCMRNLVVDSQVYDLSSAAESENTAPGCALTDGVCL-TAGG 2252

  Fly  1231 ARCWEHGNCVASLVQAKCHCQPGWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQLQLRFRT 1295
            ..|..||.|:.......|.|.||:.|..|:......:|:..|.:::.|........||.....||
Zfish  2253 PSCGVHGRCLGEWGSFSCDCHPGYSGHKCDKALPEWSFERDSVLRYQLRGGGSPRRTQAHFLLRT 2317

  Fly  1296 REQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRYG 1360
            |...|.|..::.:...|:.|||:..|:|..|.||....:.   |.||...||.|||.:|.|.|:.
Zfish  2318 RSSTGTLLSMASRDANEFIILEIVDGYLNVRANLGDGTHS---LKLTGQRVNHGQWVLISILRHD 2379

  Fly  1361 SAALMELD-GGESRRYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGIKTFEVQSDFQRSCLDDIR 1424
            :..::.|: ||.||   |.....|.:...:.....|:.|..|      :...|.||| .|:.|:|
Zfish  2380 NIFILRLEQGGGSR---EVTGVLGQKKEIVVHPSSVFLGNSA------SPNTQGDFQ-GCMRDVR 2434

  Fly  1425 LDGKHLPLPPAMNGTQWGQATMARNLERNCPSNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMS 1489
            |:|..|.|..  ..|::......|.:...|.|: .||...|..|..|||:|.::||.|...::..
Zfish  2435 LNGHSLSLDG--QSTEFSTVLERRGVVPGCHSD-ACSAKPCLSPLYCVDMWRKHECRCPANQVAV 2496

  Fly  1490 SDTKGCVDR---NECLDLPCLNGATCINLEPRLRYRCICPEGYWGENCELVQEGQRLKLSMGALG 1551
            .|....:.|   :.|....|.||.||:....: .|:|.||||:.|:.||:   ||...|.:.||.
Zfish  2497 LDEVTGLMRCAPSPCSASTCRNGGTCLAHSTK-SYQCRCPEGFRGQWCEI---GQLKSLRLAALS 2557

  Fly  1552 -----AIFVCLIIILILALIFVLYSRKRKTTKKKKRS--------GPEKDVRETVISYEDEGGGE 1603
                 ||.:||::...:.:...::::|....|.:||.        ...:|:||.:::|.:|||||
Zfish  2558 PSSILAISMCLLVFFAVLVAVTVWNQKGSRNKFRKRGVYHIPAEHESWEDIRENILNYNEEGGGE 2622

  Fly  1604 DDMTAFDITPLQIPI-----------------SAQGGPPDIAACKMPIIYPVMTLLPPGQELNVA 1651
            .|..|:|||.|:.|:                 |:||...::..|              |...|.|
Zfish  2623 QDQNAYDITELKRPLCSSLSQSSSCTTAPLIKSSQGSQEEVHPC--------------GAIQNAA 2673

  Fly  1652 YL-------------MEERKQRI----DKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDDEN 1699
            .|             .:....||    |.|:.:.|.|....:..|||||.|.|||||.|...|:.
Zfish  2674 MLPYQHHSGGHCSMDFKSYVSRIIWEADNDSLSFPMDTYHVYCIEGSGSNAGSLSSLGSFISDDG 2738

  Fly  1700 QDFNYLQNWGPRFNALAAMY 1719
            ..::.|:.||.:|..|:.:|
Zfish  2739 FSYDTLRRWGSKFEGLSELY 2758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 41/92 (45%)
Cadherin_repeat 140..248 CDD:206637 44/108 (41%)
Cadherin_repeat 256..359 CDD:206637 47/102 (46%)
Cadherin_repeat 379..481 CDD:206637 20/105 (19%)
Cadherin_repeat 489..586 CDD:206637 39/97 (40%)
Cadherin_repeat 594..703 CDD:206637 48/115 (42%)
Cadherin_repeat 724..801 CDD:206637 26/76 (34%)
EGF_CA 977..1010 CDD:238011 13/35 (37%)
LamG 1013..1198 CDD:238058 83/186 (45%)
EGF_2 <1233..1259 CDD:285248 9/25 (36%)
Laminin_G_2 1293..1428 CDD:280389 43/135 (32%)
EGF_CA 1497..1535 CDD:238011 14/40 (35%)
Cadherin_C 1583..1719 CDD:279398 48/177 (27%)
si:dkey-22o22.2XP_001921123.3 Cadherin_repeat 257..360 CDD:206637
Cadherin_repeat 355..447 CDD:206637
Cadherin_repeat 461..549 CDD:206637
Cadherin_repeat 558..657 CDD:206637
Cadherin_repeat 668..766 CDD:206637
Cadherin_repeat 775..863 CDD:206637
Cadherin_repeat 874..978 CDD:206637
Cadherin_repeat 986..1093 CDD:206637 5/12 (42%)
Cadherin_repeat 1101..1194 CDD:206637 40/92 (43%)
Cadherin_repeat 1203..1302 CDD:206637 44/108 (41%)
Cadherin_repeat 1317..1416 CDD:206637 47/99 (47%)
Cadherin_repeat 1424..1524 CDD:206637 22/116 (19%)
Cadherin_repeat 1533..1630 CDD:206637 39/96 (41%)
Cadherin_repeat 1637..1745 CDD:206637 48/116 (41%)
Cadherin_repeat 1756..1836 CDD:206637 29/83 (35%)
EGF_CA 2003..2038 CDD:238011 13/35 (37%)
LamG 2062..2223 CDD:214598 73/167 (44%)
EGF_CA 2247..2281 CDD:238011 12/34 (35%)
Laminin_G_2 2315..2438 CDD:280389 43/135 (32%)
EGF_CA 2512..2544 CDD:238011 12/32 (38%)
Cadherin_C 2602..2758 CDD:279398 48/169 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5641
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1505 1.000 Inparanoid score I101
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4879at33208
OrthoFinder 1 1.000 - - FOG0001479
OrthoInspector 1 1.000 - - mtm6342
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2878
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.870

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