DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and cdh13

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001096548.1	Gene:	cdh13 / 100125193	XenbaseID:	XB-GENE-5752189	Length:	713	Species:	Xenopus tropicalis

Alignment Length:	733	Identity:	210/733 - (28%)
Similarity:	337/733 - (45%)	Gaps:	93/733 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQITGGNI--- 78
            ::::.:...||:..:..|.|.:.::..|..........||.|...|.:.:..:.|:::..:.
Frog    12 VLSQVLVFAIANDLECIPGFQQKIFYVEQPSEFTEDQLVLNVQFNDCSGNDEVIYEVSNPDFKVE 76

  Fly    79 --GNAFAVQNTTGV-----IYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVF 136
              |:..|::|.|.|     |:..||   .|....|:::...:.|.|:...|:...|.:   |.:.
Frog    77 PDGSLIALRNITEVVRVLFIHARSP---HTDDMAEVKILGRKERHNSSKNVLKVPRHL---PFLR 135

  Fly   137 DRQTY---RTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTT 198
            .|:..   ...|.|......||.:.:|..:|......|.    |.|:|:|.:  ....|.||..|
Frog   136 HRRAIVAPSISIPENQRIPFPKIVGRVVVSDRVPGSKIR----LYGKGVDQE--PKGTFRINENT 194

  Fly   199 GDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTE 263
            |::.|.|.|||:   ..|.::..|...||.|:.:.|..|:::.:.|.|||.|.|.:|.|.|:|.|
Frog   195 GEVSVTKALDRE---AIPSYQLQVETTDENGKTIEGPVDLEILIIDQNDNRPIFREGPYVGHVLE 256

  Fly   264 NGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP---IFEIEPETGLIKTAV--CC 323
            ....|::||.|.|.|.|||. :.||.|.|    |::.:....|   :|.|:||.|.|.|.|  ..
Frog   257 GSPTGTTVMHMIAFDADDPT-TDNAVLRY----NILRQTPDKPSPNMFYIDPEKGDIVTVVSPAL 316

  Fly   324 LDRE--RTPDYSIQVVAMDGG----GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDE-TNGTYI 381
            ||||  .||.|.:.|.|.|..    ||.||.||:|.:.|.||.||:|||.|:...|.| ..|.
Frog   317 LDRETLSTPQYELIVEAKDMAGMDVGLIGTATATIVIDDKNDHPPEFTKKEFQATVKEGVTGV-- 379

  Fly   382 PETPILTVTVQDEDETNTFQYKVVPN--SGFGADKFAMVRN-GDGTGSLKIIQPLDYEDPLQSSG 443
                ::.:||:|:|:..|..:|.|..  :|.....|.:..| ....|.|.:::|||||    .|.
Frog   380 ----MVNLTVEDKDDPTTGAWKAVYTIINGNPGQSFEIHTNPKTNEGMLSVVKPLDYE----ISA 436

  Fly   444 FR-FRIQVNDKG----DDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTI 503
            |. ..|:|.::.    |.|.|.|     :.:.|.:.:.|:|:: |.|..:.:.|:..|:.::|:.
Frog   437 FHTLLIKVENEDPLIPDVGYGSS-----STATVQITVLDVNES-PVFHPDPMTVTKKENIQIGSQ 495

  Fly   504 LEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISD-RGAVSIQRPLDRET----QDRHHIQILAI 563
            |....|||.|...|..:.|.|::  :......|:. .|.::...|||||:    .:.:...||||
Frog   496 LFTVNATDPDTLQHQSIRYSILK--DEAGWLYINPLNGTINTTSPLDRESTFVLNNTYTALILAI 558

  Fly   564 DDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDPDDR-LRGNGGPFT 627
            |:|||..|.|.|..:.::|:|||||..    .||........|.|.|......|| |..|..||.
Frog   559 DNGSPPATGTGTFQITLEDINDNAPFI----HPTSAYVCEDSKDLTVVILSASDRDLHPNSDPFK 619

  Fly   628 FRLD-PLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTS 691
            |.|. ...||:   .:|:  .:.......|:::.:|:      :.:|.:|:.:.|:|.|.::.::
Frog   620 FELSKQTGSDK---AWKI--TQLNHTHAKVSLLHNLK------RANYNLPVTVTDSGKPPLSNST 673

  Fly   692 TLTVTIGDVNDNKMQPGS 709
            .|.|.:.....:||...|
Frog   674 ELKVQVCSCKKSKMDCSS 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	20/100 (20%)
		Cadherin_repeat	140..248	CDD:206637	30/110 (27%)
		Cadherin_repeat	256..359	CDD:206637	45/113 (40%)
		Cadherin_repeat	379..481	CDD:206637	28/109 (26%)
		Cadherin_repeat	489..586	CDD:206637	31/101 (31%)
		Cadherin_repeat	594..703	CDD:206637	25/110 (23%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
cdh13	NP_001096548.1	Cadherin_pro	26..112	CDD:370101	18/88 (20%)
		Cadherin_repeat	144..241	CDD:206637	30/105 (29%)
		Cadherin_repeat	249..359	CDD:206637	46/114 (40%)
		Cadherin_repeat	367..473	CDD:206637	31/120 (26%)
		Cadherin_repeat	481..581	CDD:206637	31/101 (31%)
		Cadherin_repeat	587..680	CDD:206637	25/103 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010