Protein Alignment CadN2 and CDH3

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_001784.2
• Gene: CDH3 / 1001
• HGNCID: 1762
• Length: 829
• Species: Homo sapiens
• Alignment Length: 899
• Identity: 202/899 - (22%)
• Similarity: 332/899 - (36%)
• Gaps: 281/899 - (31%)

  Fly   113 RNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFL 177
            |..|.::....|:|.:....|                   .|:|:.|:.:   :.||...|.|.:
Human   103 RRHKRDWVVAPISVPENGKGP-------------------FPQRLNQLKS---NKDRDTKIFYSI 145

  Fly   178 TGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVF--AQDEGGEGLVGYADIQV 240
            ||.|  .|:|....|.:.:.||.:.:.|||||::..     ::.:|  |..|.|..:....:|.:
Human   146 TGPG--ADSPPEGVFAVEKETGWLLLNKPLDREEIA-----KYELFGHAVSENGASVEDPMNISI 203

  Fly   241 NLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGA 305
            .:.|.||:.|:|.|..:.|:|.|....|:|||.::|.|.||...:.|..:.|||.    .:|...
Human   204 IVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIH----SQEPKD 264

  Fly   306 P---IFEIEPETGLIKTAVCCLDRERTPDY--SIQVVAMDGGGLKGTGTASIRVKDLNDMPPQFT 365
            |   :|.|...||.|......||||:.|:|  :||...|||.|...|..|.:.:.|.||..|.|.
Human   265 PHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFD 329

  Fly   366 KDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKII 430
            ..::...|.|....:  |...||||..|           .|||......:.::
Human   330 PQKYEAHVPENAVGH--EVQRLTVTDLD-----------APNSPAWRATYLIM------------ 369

  Fly   431 QPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIY 495
                                  .||||                              :|..::.:
Human   370 ----------------------GGDDG------------------------------DHFTITTH 382

  Fly   496 EDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQI 560
            .:                                       |::|.::.::.||.|.:::|.:.:
Human   383 PE---------------------------------------SNQGILTTRKGLDFEAKNQHTLYV 408

  Fly   561 LAIDDGSP----ARTATATLTVIVKDVNDNAPTFAQDYKPT-LPENV-SGKKILEVAAKDPDDRL 619
             .:.:.:|    ..|:|||:.|.|:|||: ||.|....|.. :.|.: :|:.:....|:|||
Human   409 -EVTNEAPFVLKLPTSTATIVVHVEDVNE-APVFVPPSKVVEVQEGIPTGEPVCVYTAEDPD--- 468

  Fly   620 RGNGGPFTFRLDPLASDEIKAGFKVEYDRRG----DNENGVAIISSLRPFDREAQK-----SYAI 675
                           .:..|..:::..|..|    |.::|.  ::::...|||.::     .|.:
Human   469 ---------------KENQKISYRILRDPAGWLAMDPDSGQ--VTAVGTLDREDEQFVRNNIYEV 516

  Fly   676 PIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQDTPIGRVY-VND------ 733
            .:...|||:|..|||.||.:|:.||||:...|..:.:.:.|      .:|:.:|. :.|
Human   517 MVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICN------QSPVRQVLNITDKDLSPH 575

  Fly   734 --------PDDWDVPDKKYYW--EVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQE 788
                    .||.|:     ||  ||.|      :.||.:|:::...::..|.:...:.|  ||.:
Human   576 TSPFQAQLTDDSDI-----YWTAEVNE------EGDTVVLSLKKFLKQDTYDVHLSLSD--HGNK 627

  Fly   789 DIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEP--------SKLERFRNKL 845
            :....:..||.|.........|..:...|.         ||...|..        ..|.|.:.|:
Human   628 EQLTVIRATVCDCHGHVETCPGPWKGGFIL---------PVLGAVLALLFLLLVLLLLVRKKRKI 683

  Fly   846 AE--LLYTD--RDNVDVFSVQ--LKEGSPYPLTDVHFAARSATQQPYFKAVRLNGV------VQM 898
            .|  ||..|  ||||..:..:  .:|...|.:|.:|   |....:|  :.|..|.|      ..|
Human   684 KEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLH---RGLEARP--EVVLRNDVAPTIIPTPM 743

  Fly   899 HR------EEIEKDVGLNITMVNINECL----------HEGKGK--CGSNSCTS 934
            :|      :||...:..|:...|.:...          :||.|.  ...:|.||
Human   744 YRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTS 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	4/18 (22%)
		Cadherin_repeat	140..248	CDD:206637	27/109 (25%)
		Cadherin_repeat	256..359	CDD:206637	37/107 (35%)
		CA	388..483	CDD:214520	11/94 (12%)
		Cadherin_repeat	489..586	CDD:206637	17/100 (17%)
		Cadherin_repeat	594..703	CDD:206637	29/119 (24%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
CDH3	NP_001784.2	Cadherin_pro	26..>96	CDD:471661
		CA_like	113..211	CDD:481204	30/126 (24%)
		Cadherin_repeat	219..324	CDD:206637	38/108 (35%)
		Cadherin_repeat	333..436	CDD:206637	31/219 (14%)
		Cadherin_repeat	446..544	CDD:206637	28/117 (24%)
		CA_like	551..638	CDD:481204	20/105 (19%)
		CADH_Y-type_LIR	765..824	CDD:460041	7/33 (21%)