DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and Pcdhgc5

DIOPT Version :10

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_291061.1 Gene:Pcdhgc5 / 93708 MGIID:1935205 Length:944 Species:Mus musculus


Alignment Length:947 Identity:217/947 - (22%)
Similarity:360/947 - (38%) Gaps:223/947 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   666 KDSDIISIKAKSFADREIRYTLKAQGQGAGTFNIGPTSGIVKLAKELDFEDLRQPHVYSLIVTAT 730
            |.:|::|.:.:..::...||           |::...||.:.:::::|.|.|             
Mouse    55 KGTDLLSRRLRLGSEENGRY-----------FSLSLVSGALAVSQKIDRESL------------- 95

  Fly   731 EDSGGFSTS------------VDLT---IRVTDVNDNAPKFELPDYQAHNVDEDIPLGTSILRVK 780
               .|.|||            ::||   :.:.|:|||:|.|..||.:. .:.|....|.......
Mouse    96 ---CGASTSCLLPVQVVTEHPLELTRVEVEILDLNDNSPSFATPDREM-RISESAAPGARFPLDS 156

  Fly   781 AMDSDSGSNAEIEYLVS-DDHFAVDSNGI--------IVNNKQLDADNNNAYYEFIVTAKDKGEP 836
            |.|.|.|:|....|.:| :.||::....:        :|..:|||.: ..|.::.::||.|.|.|
Mouse   157 AQDPDVGTNTVSFYTLSPNSHFSLHVKTLKDGKLFPELVLEQQLDRE-TQARHQLVLTAVDGGTP 220

  Fly   837 PKSGVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTLVTTVVASDKD-GDN----VRFGFVG 896
            .:||.:.:.|...:.||..|.|...|....:.||..|.||:..:.|:|.| |.|    ..||...
Mouse   221 ARSGTSLISVIVLDVNDNAPTFQSSVLRVGLPENTPPGTLLLRLNATDPDEGTNGQLDYSFGDHT 285

  Fly   897 GGTSSGQFVIEDITGVIRLHNKAISLDKDKYELNVTAMDDGSCCVNGDQTIHTSTAVVVVFITDV 961
            ..|....|.::..:|.|.:.......:.:.||::..|.|.|...:.|.       .|:.|.:.|.
Mouse   286 SETVKNLFGLDPSSGAIHVLGPVDFEESNFYEIHARARDQGQPAMEGH-------CVIQVDVGDA 343

  Fly   962 NDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTKFTVDEETG 1026
            |||.|.....|...| |.|..|.|:.|......|.|.|.||:|  |:...||   ..|.:.....
Mouse   344 NDNPPEVLLASLVNP-VLESTPVGTVVGLFNVRDRDSGRNGEV--SLKTSPN---LPFQIKPSEN 402

  Fly  1027 EVS--TNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQ 1089
            ..|  |::..|||..  ...::.:.|:|.|.|.|....:..:.|:|||||.|.|.:|.|...:.:
Mouse   403 HYSLLTSQPLDREAT--SHYTIELLASDAGSPPLHTHLTLRLNISDVNDNAPHFTQQLYTAYIPE 465

  Fly  1090 DASIGTNILRVSASDEDADNNGAIVYSLT------APFNPNDLEYFEIQAESGWIVLKKPLDGCY 1148
            :...|:.:..|:|||.|..:|..:.||:.      ||.:    .:..:..|.|.|..::..|   
Mouse   466 NRPPGSLLCTVAASDPDEGDNARLTYSIVGSQIQGAPAS----SFVYVNPEDGRIFAQRTFD--- 523

  Fly  1149 PRDRYRLR------VSASDKGTPASAADVDVELDVVDRNNKPPIW-----DKSIYGPIHIRENVT 1202
                |.|.      |...|.|:|...|:..:.:.|:|:|:..|..     .:....|..:..:..
Mouse   524 ----YELLQMLQIVVGVRDSGSPRLHANTSLHVFVLDQNDNAPAVLHPRPGREFSAPQRLPRSAP 584

  Fly  1203 VGTVVTSVKASSGIEG-NPTVFYRLMPGSTAQ---TNKFHTFYLQQRPDNGDTWADIKVNHPLDY 1263
            .|::||.|.|.....| |..:.|.|:|.|||.   ....||             .:::....|..
Mouse   585 PGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSAHT-------------GEVRTARALLE 636

  Fly  1264 ESIKEYNLTIRVENNGAQQLASEATVYIMLEDVN-DEIPLFT-------EREQETVL-------- 1312
            :......:.:.|.:||...|:|.|||.::|||.: :|:|..:       ||...|:.        
Mouse   637 DDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDAEEMPKSSDFLTHPPERSDLTLYLIVALAAV 701

  Fly  1313 --------------------EGEPIG--------------TKVTQVN-AIDKDGTFPNNQV---- 1338
                                :|:..|              .|.:..| .:..|||....:|    
Mouse   702 SLLSLVTFTFMSAKCLRRHEDGDRGGGHCCRGQDSPSREFYKQSSPNLQVSSDGTLKYMEVTLRP 766

  Fly  1339 ------YYYIVDSPRNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEA--------RDGAPS 1389
                  .|....||.::|.:|         .|.:.: ..::..|.|||.||        |:.:..
Mouse   767 TDSQSHCYRTCFSPASDGSDF---------TFLRPL-SVQQPSALALEPEALRSRSSTLRERSQQ 821

  Fly  1390 ARPNSNGPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYE 1454
            |.||::...|..:......:...|....:..:.::.|:     :|..:|...::..|.||     
Mouse   822 APPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEM-----LQAMILASASEAADGSS----- 876

  Fly  1455 ITSGNIGGAFAVKNMTGA-------------IYVAGA 1478
             |.|...|...:....|.             :|:.|:
Mouse   877 -TLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGS 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
CA_like 449..541 CDD:481204
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637 19/100 (19%)
Cadherin_repeat 765..853 CDD:206637 24/96 (25%)
Cadherin_repeat 862..964 CDD:206637 27/106 (25%)
Cadherin_repeat 973..1074 CDD:206637 30/102 (29%)
Cadherin_repeat 1083..1166 CDD:206637 21/94 (22%)
Cadherin_repeat <1219..1298 CDD:206637 21/82 (26%)
Cadherin_repeat 1310..1414 CDD:206637 26/164 (16%)
Cadherin_repeat 1423..1514 CDD:206637 12/69 (17%)
Cadherin_repeat 1522..1630 CDD:206637
Cadherin_repeat 1638..1741 CDD:206637
CA 1770..1863 CDD:214520
Cadherin_repeat 1871..1966 CDD:206637
Cadherin_repeat 1974..2083 CDD:206637
EGF 2350..2380 CDD:394967
LamG 2385..2570 CDD:238058
EGF_2 2605..2631 CDD:400365
LamG 2637..2797 CDD:238058
EGF_CA 2869..2907 CDD:238011
CADH_Y-type_LIR 3029..3088 CDD:460041
Pcdhgc5NP_291061.1 Cadherin_2 30..111 CDD:462413 15/82 (18%)
Cadherin_repeat 139..238 CDD:206637 25/100 (25%)
Cadherin_repeat 246..346 CDD:206637 27/106 (25%)
Cadherin_repeat 359..450 CDD:206637 29/97 (30%)
Cadherin_repeat 459..560 CDD:206637 26/111 (23%)
Cadherin_repeat 578..670 CDD:206637 27/104 (26%)
Cadherin_C_2 689..791 CDD:465139 15/110 (14%)
Cadherin_tail 823..>917 CDD:435046 16/101 (16%)
Blue background indicates that the domain is not in the aligned region.

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