DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Pcdhgc5

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_291061.1	Gene:	Pcdhgc5 / 93708	MGIID:	1935205	Length:	944	Species:	Mus musculus

Alignment Length:	947	Identity:	217/947 - (22%)
Similarity:	360/947 - (38%)	Gaps:	223/947 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   666 KDSDIISIKAKSFADREIRYTLKAQGQGAGTFNIGPTSGIVKLAKELDFEDLRQPHVYSLIVTAT 730
            |.:|::|.:.:..::...||           |::...||.:.:::::|.|.|
Mouse    55 KGTDLLSRRLRLGSEENGRY-----------FSLSLVSGALAVSQKIDRESL------------- 95

  Fly   731 EDSGGFSTS------------VDLT---IRVTDVNDNAPKFELPDYQAHNVDEDIPLGTSILRVK 780
               .|.|||            ::||   :.:.|:|||:|.|..||.:. .:.|....|.......
Mouse    96 ---CGASTSCLLPVQVVTEHPLELTRVEVEILDLNDNSPSFATPDREM-RISESAAPGARFPLDS 156

  Fly   781 AMDSDSGSNAEIEYLVS-DDHFAVDSNGI--------IVNNKQLDADNNNAYYEFIVTAKDKGEP 836
            |.|.|.|:|....|.:| :.||::....:        :|..:|||.: ..|.::.::||.|.|.|
Mouse   157 AQDPDVGTNTVSFYTLSPNSHFSLHVKTLKDGKLFPELVLEQQLDRE-TQARHQLVLTAVDGGTP 220

  Fly   837 PKSGVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTLVTTVVASDKD-GDN----VRFGFVG 896
            .:||.:.:.|...:.||..|.|...|....:.||..|.||:..:.|:|.| |.|    ..||...
Mouse   221 ARSGTSLISVIVLDVNDNAPTFQSSVLRVGLPENTPPGTLLLRLNATDPDEGTNGQLDYSFGDHT 285

  Fly   897 GGTSSGQFVIEDITGVIRLHNKAISLDKDKYELNVTAMDDGSCCVNGDQTIHTSTAVVVVFITDV 961
            ..|....|.::..:|.|.:.......:.:.||::..|.|.|...:.|.       .|:.|.:.|.
Mouse   286 SETVKNLFGLDPSSGAIHVLGPVDFEESNFYEIHARARDQGQPAMEGH-------CVIQVDVGDA 343

  Fly   962 NDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTKFTVDEETG 1026
            |||.|.....|...| |.|..|.|:.|......|.|.|.||:|  |:...||   ..|.:.....
Mouse   344 NDNPPEVLLASLVNP-VLESTPVGTVVGLFNVRDRDSGRNGEV--SLKTSPN---LPFQIKPSEN 402

  Fly  1027 EVS--TNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQ 1089
            ..|  |::..|||..  ...::.:.|:|.|.|.|....:..:.|:|||||.|.|.:|.|...:.:
Mouse   403 HYSLLTSQPLDREAT--SHYTIELLASDAGSPPLHTHLTLRLNISDVNDNAPHFTQQLYTAYIPE 465

  Fly  1090 DASIGTNILRVSASDEDADNNGAIVYSLT------APFNPNDLEYFEIQAESGWIVLKKPLDGCY 1148
            :...|:.:..|:|||.|..:|..:.||:.      ||.:    .:..:..|.|.|..::..|
Mouse   466 NRPPGSLLCTVAASDPDEGDNARLTYSIVGSQIQGAPAS----SFVYVNPEDGRIFAQRTFD--- 523

  Fly  1149 PRDRYRLR------VSASDKGTPASAADVDVELDVVDRNNKPPIW-----DKSIYGPIHIRENVT 1202
                |.|.      |...|.|:|...|:..:.:.|:|:|:..|..     .:....|..:..:..
Mouse   524 ----YELLQMLQIVVGVRDSGSPRLHANTSLHVFVLDQNDNAPAVLHPRPGREFSAPQRLPRSAP 584

  Fly  1203 VGTVVTSVKASSGIEG-NPTVFYRLMPGSTAQ---TNKFHTFYLQQRPDNGDTWADIKVNHPLDY 1263
            .|::||.|.|.....| |..:.|.|:|.|||.   ....||             .:::....|..
Mouse   585 PGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSAHT-------------GEVRTARALLE 636

  Fly  1264 ESIKEYNLTIRVENNGAQQLASEATVYIMLEDVN-DEIPLFT-------EREQETVL-------- 1312
            :......:.:.|.:||...|:|.|||.::|||.: :|:|..:       ||...|:.
Mouse   637 DDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDAEEMPKSSDFLTHPPERSDLTLYLIVALAAV 701

  Fly  1313 --------------------EGEPIG--------------TKVTQVN-AIDKDGTFPNNQV---- 1338
                                :|:..|              .|.:..| .:..|||....:|
Mouse   702 SLLSLVTFTFMSAKCLRRHEDGDRGGGHCCRGQDSPSREFYKQSSPNLQVSSDGTLKYMEVTLRP 766

  Fly  1339 ------YYYIVDSPRNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEA--------RDGAPS 1389
                  .|....||.::|.:|         .|.:.: ..::..|.|||.||        |:.:..
Mouse   767 TDSQSHCYRTCFSPASDGSDF---------TFLRPL-SVQQPSALALEPEALRSRSSTLRERSQQ 821

  Fly  1390 ARPNSNGPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYE 1454
            |.||::...|..:......:...|....:..:.::.|:     :|..:|...::..|.||
Mouse   822 APPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEM-----LQAMILASASEAADGSS----- 876

  Fly  1455 ITSGNIGGAFAVKNMTGA-------------IYVAGA 1478
             |.|...|...:....|.             :|:.|:
Mouse   877 -TLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGS 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637	19/100 (19%)
		Cadherin_repeat	765..853	CDD:206637	24/96 (25%)
		Cadherin_repeat	862..964	CDD:206637	27/106 (25%)
		Cadherin_repeat	973..1074	CDD:206637	30/102 (29%)
		Cadherin_repeat	1083..1166	CDD:206637	21/94 (22%)
		Cadherin_repeat	<1219..1298	CDD:206637	21/82 (26%)
		Cadherin_repeat	1310..1414	CDD:206637	26/164 (16%)
		Cadherin_repeat	1423..1514	CDD:206637	12/69 (17%)
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437
		LamG	2385..2570	CDD:238058
		EGF_2	<2605..2631	CDD:285248
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Pcdhgc5	NP_291061.1	Cadherin_2	30..111	CDD:285466	15/82 (18%)
		Cadherin_repeat	139..238	CDD:206637	25/100 (25%)
		Cadherin_repeat	246..346	CDD:206637	27/106 (25%)
		Cadherin_repeat	359..450	CDD:206637	29/97 (30%)
		Cadherin_repeat	459..560	CDD:206637	26/111 (23%)
		Cadherin_repeat	578..670	CDD:206637	27/104 (26%)
		Cadherin_C_2	689..791	CDD:293101	15/110 (14%)
		Cadherin_tail	821..>917	CDD:292596	17/103 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000