DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN and Cntnap1

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	XP_008766344.1	Gene:	Cntnap1 / 84008	RGDID:	70902	Length:	1387	Species:	Rattus norvegicus

Alignment Length:	872	Identity:	175/872 - (20%)
Similarity:	255/872 - (29%)	Gaps:	309/872 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2300 QMCEGSCTNSLEIS-----PLPYMVNANKTA--LVGVRVDTIADCTCGARNFTKPESCRTTPCHN 2357
            |..|.||.||..::     |..:.:..|:..  ..|.....|..|.||...
  Rat   678 QWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDQ-------------- 728

  Fly  2358 GGRCVDTRFGPHCSC------------------------------------------PVGYTGPR 2380
              .|:|...  ||:|                                          |:...|.|
  Rat   729 --SCIDPAL--HCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSSSEAQFFLRPLRCYGDR 789

  Fly  2381 CQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYN--GPIVPPERDETLISDFIALE 2443
            ....|.|||......:||:.......:|..|.|..|.|:.:.|  ||.....|      .::.:|
  Rat   790 NSWNTISFRTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPFCQWRR------PYVRVE 848

  Fly  2444 LERGYPRLL-IDFGSGTLELRVKTKK-TLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGT 2506
            |......:. .|.|:|...|.|.:.. ..:|.|||.:....:.:..|:.||.            .
  Rat   849 LNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDH------------R 901

  Fly  2507 PPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNS 2571
            |.....|         |...|:.:            ::||.||........:.|.||:|.:..|.
  Rat   902 PWVLRPM---------PLQTYIWL------------EYDQPLYVGSAELKRRPFVGCLRAMRLNG 945

  Fly  2572 KLYDL-----AHPGLSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEARCHC-RPGWTGPA 2630
            ...:|     |..|...|....|         |.....|:..|.||...|...|.| ...:.||.
  Rat   946 VTLNLEGRANASEGTFPNCTGHC---------THPRFPCFHGGRCVERYSYYTCDCDLTAFDGPY 1001

  Fly  2631 CNIPTIPTTFKAQSYVKYAL--------------------SFEPDRF------------------ 2657
            || ..|...|:..::::|.|                    .:||...
  Rat  1002 CN-HDIGGFFETGTWMRYNLQSALRSAAQEFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYR 1065

  Fly  2658 ----------------------STQVQLRFRTREEYGELFRVSDQHNREYGILEIK-DGHLHFRY 2699
                                  ..:|...|.|......|..|| ...|:|..:.|| ||.|..||
  Rat  1066 LPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVS-SFVRDYMAVLIKEDGTLQLRY 1129

  Fly  2700 NLNSLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNETFEFVGHQW-LLVDK 2763
            .|.   |......|....|.|||.|.|.:.|......:::|         .|.....:: ||||.
  Rat  1130 QLG---TSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVD---------YFPLTEQKFSLLVDS 1182

  Fly  2764 Q----EGVYAGGKAEYTGVRTFEVYADYQ----KSCLDDIRLEG-----KHLPLPPAMNGTQWGQ 2815
            |    :.:|.|...| |||...|:.. |.    ..||..:|...     .|...|..|.
  Rat  1183 QLDSPKALYLGRVME-TGVIDPEIQR-YNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMT------ 1239

  Fly  2816 ATMARNL-------EKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNEC 2873
            |.:|..:       |..|.:.....:.:.|:    :|.|           .:.||.....|
  Rat  1240 AELAEAMRVQGELSESNCGAMPRLVSEVPPE----LDPW-----------YLPPDFPYYHD---- 1285

  Fly  2874 LDMPCMNGATCINLEPRLRYRCICPDGFWGENCELVQEGQTLKLSMGALAAILVCLLIILILVLV 2938
                                     || |            :.:.:|.|.|.|  ||.::.::::
  Rat  1286 -------------------------DG-W------------IAILLGFLVAFL--LLGLVGMLVL 1310

  Fly  2939 FVVYNRRREAHIKYPGPDDDVRENIINYDDEGGGEDDMTAFDITPLQIPIGGPM---PPELAPMK 3000
            |.:.|.|      |.| .....|....:|...||:        .||  |..||.   .|..||.:
  Rat  1311 FYLQNHR------YKG-SYHTNEPKATHDSHPGGK--------APL--PPSGPAQAPAPTPAPTQ 1358

  Fly  3001 MPIMYPVMTLMPG-QEPNVGMFIEEHK 3026
            :|...|.....|| ::.|:...:||.:
  Rat  1359 VPTPAPAPASGPGPRDQNLPQILEESR 1385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	7/71 (10%)
		LamG	2385..2570	CDD:238058	41/188 (22%)
		EGF_2	<2605..2631	CDD:285248	9/26 (35%)
		Laminin_G_2	2665..2800	CDD:280389	42/149 (28%)
		EGF_CA	2869..2907	CDD:238011	4/37 (11%)
		Cadherin_C	2952..3088	CDD:279398	21/79 (27%)
Cntnap1	XP_008766344.1	FA58C	25..175	CDD:214572
		FA58C	37..174	CDD:238014
		LamG	182..337	CDD:238058
		LamG	369..520	CDD:238058
		EGF	551..580	CDD:278437
		FReD	591..>665	CDD:294064
		LamG	794..944	CDD:238058	41/188 (22%)
		LamG	1090..1225	CDD:214598	43/149 (29%)
		4.1m	1311..1329	CDD:128590	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910