DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN and Cdh1

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_112624.1 Gene:Cdh1 / 83502 RGDID:69279 Length:886 Species:Rattus norvegicus


Alignment Length:1746 Identity:298/1746 - (17%)
Similarity:445/1746 - (25%) Gaps:971/1746 - (55%)


- Green bases have known domain annotations that are detailed below.


  Fly  1416 PYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVAGALD 1480
            |.|...:|...|.|....:..:|          .|:::|..:|....||..::....:...|.: 
  Rat    34 PGFSSEVYTFLVPERHLERGHIL----------GRVKFEGCTGRPRTAFFSEDSRFKVSTDGVI- 87

  Fly  1481 YETRRRYELRLAASDNLKENYTTVIIHVKDVN----------------------------DNPPV 1517
              |.:|: |:|...:      |:.::|..|.:                            .||.:
  Rat    88 --TVKRH-LKLHKLE------TSFLVHAWDSSYRKLSTKVTLKSLGHHHHRHHHRDPVSESNPEL 143

  Fly  1518 FERPTYRTQI--------------TEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDN 1568
            ...|::...:              .|......|:|::|:.:   ::|:...:.|.:||.|  .|.
  Rat   144 LTFPSFHQGLRRQKRDWVIPPINCPENQKGEFPQRLVQIKS---NRDKETTVFYSITGPG--ADK 203

  Fly  1569 PANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVF--AQDEGGEGLVGYADVQVNLKDINDNA 1631
            |....|.|.|.||.:.|.:||||:..:     ::.::  |....||.:....::.|.:.|.|||.
  Rat   204 PPVGVFIIERETGWLKVTQPLDREAID-----KYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNR 263

  Fly  1632 PIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSP---IFEIE 1693
            |.|.|.|:.|:|.|....|..||.::|.|.||.....||.:.|:|    :.::...|   :|.:.
  Rat   264 PEFIQEVFEGSVAEGALPGTSVMQVSATDADDDINTYNAAIAYTI----LSQDPELPHKNMFTVN 324

  Fly  1694 PDTGVIKTAVCCLDRERTPDYSIQVVAMD--GGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVD 1756
            .|||||......||||..|.|::.|.|.|  |.||..|..|.|.||||||..|.|....:..:|.
  Rat   325 RDTGVISVVTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPIFNPSTYQGQVL 389

  Fly  1757 ETDGTALPEMPILTVTVHDEDETN----KFQYKVIDNSGYGADKFTMV---RNNDGTGSLKIVQP 1814
            |.:..|    .|.|:.|.|:|..|    ...|.|:::..:   :||::   :.|:|.  ||..:.
  Rat   390 ENEVGA----RIATLKVTDDDAPNTPAWNAVYTVVNDPDH---QFTVITDPKTNEGI--LKTAKG 445

  Fly  1815 LDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTK 1879
            ||:|.:.|     :.:.|..:.|:........:.:.|.|.:.|:|: .|.|..|...|.|.||..
  Rat   446 LDFEAKQQ-----YILHVTVENEEPFEGSLVPSTATVTVDVVDVNE-APIFVPAEKRVEVPEDFG 504

  Fly  1880 VGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAIN-QNGSVTIQRSLDREVVPRHQVK---- 1939
            ||.|:..:.|.:||...:.|::|.|.|  |......|| :.|.::.:..:|||  ....||    
  Rat   505 VGLEIASYTAREPDTFMEQKITYRIWR--DTANWLEINPETGVISTRAEMDRE--DSEHVKNSTY 565

  Fly  1940 ---ILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKVVEILATDDDDRSKS 2001
               |:|.|||||..|.|.||.:::.|:|||||         :||   ||.:              
  Rat   566 TALIIATDDGSPIATGTGTLLLVLSDVNDNAP---------IPE---PRNM-------------- 604

  Fly  2002 NGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIKDHGSPA 2066
                                                      .|.:...|.::|.|:        
  Rat   605 ------------------------------------------QFCQRNPKPHVITIL-------- 619

  Fly  2067 MTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKKFYWEAMEH 2131
                                                                             
  Rat   620 ----------------------------------------------------------------- 619

  Fly  2132 PRFKLDEDSGMVTMRAGTREGRYHLRFKVYDRKHTQTDIPANVTVTVREIPHEAVVNSGSVRLSG 2196
                                               ..|:|.|.:....|:.|.|.||        
  Rat   620 -----------------------------------DPDLPPNTSPFTAELTHGASVN-------- 641

  Fly  2197 ISDEDFIRVWNYRTQSMSRSKMDRFRDKLADLLNTERENVDIFSVQLKRKHPPLTDVRFSAHGSP 2261
                                                                             
  Rat   642 ----------------------------------------------------------------- 641

  Fly  2262 YYKPVRLNGIVLMHREEIEKDVGINITMVGIDECLYENQMCEGSCTNSLEISPLPYMVNANKTAL 2326
                                                                             
  Rat   642 ----------------------------------------------------------------- 641

  Fly  2327 VGVRVDTIADCTCGARNFTKPESCRTTPCHNGGRCVDTRFGPHCSCPVGYTGPRCQQTTRSFRGN 2391
                                                                             
  Rat   642 ----------------------------------------------------------------- 641

  Fly  2392 GWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFG 2456
             |.    :|..|....||                |:.|.:|                        
  Rat   642 -WT----IEYNDAEQESL----------------ILQPRKD------------------------ 661

  Fly  2457 SGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQI 2521
                                                                             
  Rat   662 ----------------------------------------------------------------- 661

  Fly  2522 PPFNEYLNVNAPLQVGGLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSV 2586
                        |::|                                                 
  Rat   662 ------------LEIG------------------------------------------------- 665

  Fly  2587 AGCPQTEEVCAQTETTARCWEHGNCVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQSYVKYALS 2651
                                                                             
  Rat   666 ----------------------------------------------------------------- 665

  Fly  2652 FEPDRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAI 2716
                              ||....::||..|::                                
  Rat   666 ------------------EYKINLKLSDNQNKD-------------------------------- 680

  Fly  2717 VVNDGQWHVVKVNRYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTF 2781
                            ...|||                                           
  Rat   681 ----------------QVTTLE------------------------------------------- 686

  Fly  2782 EVYADYQKSCLDDIRLEGKHLPLPPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDPFECVDL 2846
                                                                             
  Rat   687 ----------------------------------------------------------------- 686

  Fly  2847 WNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPRLRYRCICPDGFWGENCELVQE 2911
              |:.|.| ||.:           |.|:        ..|:||..|:...|               
  Rat   687 --VHVCDC-EGTV-----------NNCM--------KAISLEAGLQVPAI--------------- 714

  Fly  2912 GQTLKLSMGALAAILVCLLIILILVLVFVVYNRRREAHIKYP--GPDDDVRENIINYDDEGGGED 2974
                   :|.|..|| .|||:::|:|:|:    ||...:|.|  .||||.|:|:..||:|||||:
  Rat   715 -------LGILGGIL-ALLILILLLLLFL----RRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEE 767

  Fly  2975 DMTAFDITPLQIPIGGPMPPE-----LAP--MKMPIMYPVMTLMPGQEPNVGMFIEEHKKRADGD 3032
            |.. ||::  |:..|....||     :||  |.||...|    .|.....:|.||:|:.|.||.|
  Rat   768 DQD-FDLS--QLHRGLDARPEVIRNDVAPTLMSMPQYRP----RPANPDEIGNFIDENLKAADSD 825

  Fly  3033 PNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3088
            |.|||:|.|..:.|||.||.|.|||||.|...|:.|:||||..||.||.|||:|||
  Rat   826 PTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 881

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637 17/118 (14%)
Cadherin_repeat 1522..1630 CDD:206637 27/123 (22%)
Cadherin_repeat 1638..1741 CDD:206637 41/107 (38%)
Cadherin_repeat 1762..1861 CDD:206637 25/105 (24%)
Cadherin_repeat 1871..1966 CDD:206637 36/102 (35%)
Cadherin_repeat 1974..2083 CDD:206637 8/108 (7%)
EGF 2350..2380 CDD:278437 0/29 (0%)
LamG 2385..2570 CDD:238058 10/184 (5%)
EGF_2 <2605..2631 CDD:285248 0/25 (0%)
Laminin_G_2 2665..2800 CDD:280389 8/134 (6%)
EGF_CA 2869..2907 CDD:238011 7/37 (19%)
Cadherin_C 2952..3088 CDD:279398 68/144 (47%)
Cdh1NP_112624.1 Cadherin_pro 31..120 CDD:285913 19/105 (18%)
CA_like 162..262 CDD:206635 27/109 (25%)
Cadherin_repeat 270..375 CDD:206637 42/108 (39%)
Cadherin_repeat 383..>462 CDD:206637 22/92 (24%)
Cadherin_repeat 496..595 CDD:206637 36/102 (35%)
Cadherin 608..690 CDD:278457 30/804 (4%)
Cadherin_C 745..881 CDD:279398 67/142 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 751..771 11/20 (55%)
Required for binding CTNND1 and PSEN1. /evidence=ECO:0000250 762..773 7/11 (64%)
Required for binding alpha, beta and. /evidence=ECO:0000250 815..886 40/67 (60%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 130 1.000 Domainoid score I5067
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.