DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN and Cdh2

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_112623.2 Gene:Cdh2 / 83501 RGDID:69280 Length:906 Species:Rattus norvegicus


Alignment Length:1742 Identity:299/1742 - (17%)
Similarity:462/1742 - (26%) Gaps:946/1742 - (54%)


- Green bases have known domain annotations that are detailed below.


  Fly  1418 FDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITS------GNIGGAFAVKNM----TGA 1472
            |.:::|.|.:.::......:|.|...:.:...:::||.:.      ...|..:||::.    ..|
  Rat    36 FPEAVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLSAEQA 100

  Fly  1473 IYVAGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQITE-------- 1529
            .::..|.|.||:.:::  :|.:.:|:.:.|      ::....|...|...:..|:.:        
  Rat   101 KFLIYAQDKETQEKWQ--VAVNLSLEPSLT------EEPMKEPHEIEEIVFPRQLAKHSGALQRQ 157

  Fly  1530 ------------EDDRN-LPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTG 1581
                        |:.|. .|:.::::.:   |:|:..::.|.:||.|  .|.|....|.||..:|
  Rat   158 KRDWVIPPINLPENSRGPFPQELVRIRS---DRDKNLSLRYSVTGPG--ADQPPTGIFIINPISG 217

  Fly  1582 EIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTEN 1646
            ::.|.|||||:.   ..::.....|.|..|..:....|:.:|:.|:|||.|.|...|:.|:|.|.
  Rat   218 QLSVTKPLDREL---IARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEG 279

  Fly  1647 GTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSP-IFEIEPDTGVIKTAVCCLDRER 1710
            ...|..|||:||:|.|||| ..|..|.|.|....  ..|.|| :|.|..:||.|.|....||||:
  Rat   280 SKPGTYVMTVTAIDADDPN-ALNGMLRYRILSQA--PSTPSPNMFTINNETGDIITVAAGLDREK 341

  Fly  1711 TPDYS--IQVVAMDGG---GLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILT 1770
            ...|:  ||...|:|.   ||..|.||.|.|.|:||.||:||...::.||.|.....:  :..||
  Rat   342 VQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVI--VANLT 404

  Fly  1771 VTVHDEDETNKFQ--YKVIDNSGYGADKFTMVRN-NDGTGSLKIVQPLDYEDQLQSNGFRFRIQV 1832
            ||..|:..|..:.  |::  :.|....:|.::.: |...|.:.:|:|:|:|              
  Rat   405 VTDKDQPHTPAWNAAYRI--SGGDPTGRFAILTDPNSNDGLVTVVKPIDFE-------------- 453

  Fly  1833 NDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGK 1897
                                                                             
  Rat   454 ----------------------------------------------------------------- 453

  Fly  1898 SKVSYSIDRSSDRQRQFAINQNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQD 1962
                        ..|.|.:.              |...:||.:.......|..|||.::|||  |
  Rat   454 ------------TNRMFVLT--------------VAAENQVPLAKGIQHPPQSTATVSVTVI--D 490

  Fly  1963 INDNA-----PKFLKDYRPVLPEHVPPRKVVEILATDDDDR--------SKSNGPPFQFRLDPSA 2014
            :|:|.     ||.::.     .|.:....::..|...|.||        :|.:.|....::||  
  Rat   491 VNENPYFAPNPKIIRQ-----EEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDP-- 548

  Fly  2015 DDIIRASFKVEQDQKGANGDGMAVISSLRSFDRE----QQKEYMIPIVIKDHGSPAMTGTSTLTV 2075
                            .||.    |:::...|||    :...|....:..|:|.|.|:||.||.:
  Rat   549 ----------------VNGQ----ITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQI 593

  Fly  2076 IIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDDWDLPDKKFYWEAMEHPRFKLDEDS 2140
            .:.|:|||..|                                                      
  Rat   594 YLLDINDNAPQ------------------------------------------------------ 604

  Fly  2141 GMVTMRAGTREGRYHLRFKVYDRKHTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRV 2205
                                                   .:|.||                    
  Rat   605 ---------------------------------------VLPQEA-------------------- 610

  Fly  2206 WNYRTQSMSRSKMDRFRDKLADLLNTERENVDIFSVQLKRKHPPLTDVRFSAHGSPYYKPVRLNG 2270
                                                                             
  Rat   611 ----------------------------------------------------------------- 610

  Fly  2271 IVLMHREEIEKDVGINITMVGIDECLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIA 2335
                                         :.||....||:.|:.|.|.::.|.            
  Rat   611 -----------------------------ETCETPEPNSINITALDYDIDPNA------------ 634

  Fly  2336 DCTCGARNFTKPESCRTTPCHNGGRCVDTRFGPHCSCPVGYTGPRCQQTTRSFRGNGWAWYPPLE 2400
                                                                             
  Rat   635 ----------------------------------------------------------------- 634

  Fly  2401 MCDESHLSLEFITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVK 2465
                                   ||.                                       
  Rat   635 -----------------------GPF--------------------------------------- 637

  Fly  2466 TKKTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNV 2530
                                                                             
  Rat   638 ----------------------------------------------------------------- 637

  Fly  2531 NAPLQVGGLYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEV 2595
                                                                             
  Rat   638 ----------------------------------------------------------------- 637

  Fly  2596 CAQTETTARCWEHGNCVGSLSEARCHCRPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFSTQ 2660
                                              |.::|..|.|.|.                  
  Rat   638 ----------------------------------AFDLPLSPVTIKR------------------ 650

  Fly  2661 VQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHV 2725
                                                                         .|.:
  Rat   651 -------------------------------------------------------------NWTI 654

  Fly  2726 VKVNRYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKS 2790
            .::|            |:..:.|...:|:         :.|:|                      
  Rat   655 TRLN------------GDFAQLNLKIKFL---------EAGIY---------------------- 676

  Fly  2791 CLDDIRLEGKHLPLPPAMNGTQWGQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCG 2855
                      .:|:....:|                  |.|.||         :.:..|..|.| 
  Rat   677 ----------EVPIVITDSG------------------NPPKSN---------ISILRVKVCQC- 703

  Fly  2856 EGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPRLRYRCICPDGFWGENCELVQEGQTLKLSMG 2920
                   ||.|     :|.|:..:.||                                 .|..|
  Rat   704 -------DSNG-----DCTDVDRIVGA---------------------------------GLGTG 723

  Fly  2921 ALAAILVCLLIILILVLVFVVYNRR----REAHIKYPGPDDDVRENIINYDDEGGGEDDMTAFDI 2981
            |:.|||:|::|:|||||:|||:.:|    |:|......|:||||:||:.||:|||||:|.. :|:
  Rat   724 AIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDL 787

  Fly  2982 TPLQIPIGGPMPPELAPM------KMPI----MYPVMTLMPGQEPNVGMFIEEHKKRADGDPNAP 3036
            :.||.| ....|..:.|:      :.||    .|||.:..| ...::|.||.|..|.||.||.||
  Rat   788 SQLQQP-DTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAP-HPGDIGDFINEGLKAADNDPTAP 850

  Fly  3037 PFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3088
            |:|.|..:.|||.||||||||||.|.:....|:||||..|||||.|||:|||
  Rat   851 PYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYG 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637 17/100 (17%)
Cadherin_repeat 1522..1630 CDD:206637 29/128 (23%)
Cadherin_repeat 1638..1741 CDD:206637 45/108 (42%)
Cadherin_repeat 1762..1861 CDD:206637 15/101 (15%)
Cadherin_repeat 1871..1966 CDD:206637 14/94 (15%)
Cadherin_repeat 1974..2083 CDD:206637 26/120 (22%)
EGF 2350..2380 CDD:278437 0/29 (0%)
LamG 2385..2570 CDD:238058 2/184 (1%)
EGF_2 <2605..2631 CDD:285248 0/25 (0%)
Laminin_G_2 2665..2800 CDD:280389 7/134 (5%)
EGF_CA 2869..2907 CDD:238011 4/37 (11%)
Cadherin_C 2952..3088 CDD:279398 69/145 (48%)
Cdh2NP_112623.2 Cadherin_pro 31..121 CDD:400897 16/86 (19%)
CA_like 163..263 CDD:421687 28/107 (26%)
Cadherin_repeat 273..378 CDD:206637 45/107 (42%)
Cadherin_repeat 386..494 CDD:206637 32/218 (15%)
Cadherin_repeat 508..601 CDD:206637 26/114 (23%)
Cadherin 608..701 CDD:421759 31/668 (5%)
Cadherin_C 751..904 CDD:395833 73/155 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..883 11/19 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 130 1.000 Domainoid score I5067
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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