DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and Celsr2

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_001178039.1 Gene:Celsr2 / 83465 RGDID:69237 Length:2919 Species:Rattus norvegicus


Alignment Length:2118 Identity:527/2118 - (24%)
Similarity:806/2118 - (38%) Gaps:580/2118 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   966 PVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTK-FTVDEETGEVS 1029
            |.|:..| |...|.|..|.|:.|..:.|.|.|:|..|:::|::....:.:... |::|..||.|:
  Rat   179 PQFQPPS-YQATVPENQPAGTSVASLRAIDPDEGEAGRLEYTMDALFDSRSNHFFSLDPITGAVT 242

  Fly  1030 TNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQDASIG 1094
            |.:..|||........||  |.|.|.|....:.:.|:.:||.||:.|:|::|:|.|:::::..:|
  Rat   243 TAEELDRETKSTHVFRVT--AQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVG 305

  Fly  1095 TNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLKKPLDGCYPRDR---YRLR 1156
            ..:|.|.|:|.||..|..|:|.|......:..|.|||...||.|..:.|:|    |:.   |:|.
  Rat   306 YEVLTVRATDGDAPPNANILYRLLEGPGGSPSEVFEIDPRSGVIRTRGPVD----REEVESYKLI 366

  Fly  1157 VSASDKGT---PASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGTVVTSVKASSGIEG 1218
            |.|||:|.   |.|:..| |.|.|.|.|:..|.:.:..| .:.:||:||.|..|..|.||...:|
  Rat   367 VEASDQGRDPGPRSSTAV-VFLSVEDDNDNAPQFSEKRY-VVQVREDVTPGAPVLRVTASDRDKG 429

  Fly  1219 -NPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQ 1282
             |..|.|.:|.|     |....|||     :..|.| :.|..|||||:.|||.|.||.::.|...
  Rat   430 SNALVHYSIMSG-----NARGQFYL-----DAQTGA-LDVVSPLDYETTKEYTLRIRAQDGGRPP 483

  Fly  1283 LAS-EATVYIMLEDVNDEIPLFTERE-QETVLEGEPIGTKVTQVNAIDKDGTFPNNQVYYYIVDS 1345
            |:: ...|.:.:.|:||..|:|.... |.||||..|:|..|..|.|||.|.. .|.::.|    |
  Rat   484 LSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG-ENARLEY----S 543

  Fly  1346 PRNEGKEF-FEINLQSGEIFTKTVFDREKKGAYALEVEARD-GAPSARPNSNGPNSVTKFIRIGI 1408
            ....|.:| |.||..:|.|......|||:...|:..||||| |.|:...:::        :.:.|
  Rat   544 LAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASAS--------VSVTI 600

  Fly  1409 ADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGA- 1472
            .|.|||.|.|.:..|...::|:..:..:|:||:|.|.|..|.|.|:|||||....|::.:.:|. 
  Rat   601 LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGG 665

  Fly  1473 -IYVAGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLP 1536
             :.:|..|||:..|:|.|.:.|||..:::...::::|.|.|.:.|||:...|...:.|       
  Rat   666 LVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNE------- 723

  Fly  1537 KRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWR 1601
                         |||                                                 
  Rat   724 -------------DRP------------------------------------------------- 726

  Fly  1602 FTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNE 1666
                                                           ||..|:.::|.|.|   .
  Rat   727 -----------------------------------------------AGTTVVLISATDED---T 741

  Fly  1667 GSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGT 1731
            |.|||:.|.:|.::       |.|.|:.|||.:.|..                            
  Rat   742 GENARITYFMEDSI-------PQFRIDADTGAVTTQA---------------------------- 771

  Fly  1732 ASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGADK 1796
                                                                             
  Rat   772 ----------------------------------------------------------------- 771

  Fly  1797 FTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDN 1861
                             .||||||:   .:...|...|.|....:|.     :::.:.:.|:|||
  Rat   772 -----------------ELDYEDQV---SYTLAITARDNGIPQKSDT-----TYLEILVNDVNDN 811

  Fly  1862 KPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAI-NQNGSVTIQ 1925
            .|.|.|.:.:.||:||....|.:.:..|||.|.|...:|.|:.....|....|.: :.:|.|...
  Rat   812 APQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876

  Fly  1926 RSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPP--RKVV 1988
            |.||||.|.::.::..|:|.|.||......:||.|.|:|||.|.|.:|...|..|...|  ..|.
  Rat   877 RRLDRENVAQYILRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA 941

  Fly  1989 EILATDDDDRSKS--------NGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSF 2045
            .:.|||.|:.:.:        ...|..|:||..:.:                      :::|...
  Rat   942 RVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE----------------------LTALVDL 984

  Fly  2046 DREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNY----QGQSPDTPI 2106
            |.|.:.||:  :||:...:| :...:|:.|.:.|.|||....|:.:|...||    ....|...|
  Rat   985 DYEDRPEYI--LVIQATSAP-LVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAI 1046

  Fly  2107 GRVYVYDLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTREGRYH------------LRFK 2159
            |||..:|.   |:.|...|       .|:...:..:|.:.|.|.|.|..            :...
  Rat  1047 GRVPAHDP---DISDSLTY-------SFERGNELSLVLLNASTGELRLSRALDNNRPLEAIMSVL 1101

  Fly  2160 VYDRKHTQTDIPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDK 2224
            |.|..|:.|   |..::.|..|..|.:.:|.::||..:|.|.|:           ...:..|...
  Rat  1102 VSDGVHSVT---AQCSLRVTIITDEMLTHSITLRLEDMSPERFL-----------SPLLGLFIQA 1152

  Fly  2225 LADLLNTERENVDIFSVQLKRKHP--PLTDVRFSAHGSPYYKPVRLNGIVLMHREEIEKDVGIN- 2286
            :|..|.|..::|.:|:||.....|  .:.:|..|. |.|   |....|...:..|::::.:.:| 
  Rat  1153 VAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSV-GQP---PGPGGGPPFLPSEDLQERLYLNR 1213

  Fly  2287 --ITMVGIDECL-YENQMC-EGSCTNSLEI-------SPLPYMVNAN----------------KT 2324
              :|.:.....| :::.:| ...|.|.:..       |..|::.:::                ..
  Rat  1214 SLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPP 1278

  Fly  2325 ALVGVRVDTIAD------------C-------TCGARNFTKPESC-------RTTP--CHNGGRC 2361
            ...|...:|..|            |       ||..|:....|.|       |.||  |.|||.|
  Rat  1279 GFTGDYCETEVDLCYSRPCGPHGHCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTC 1343

  Fly  2362 VDTRFGP-HCSCPVG-YTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNG 2424
            |:...|. .|.||.| :..|.||.|||||....:..:..|.......|:|.|.|::.|||::|||
  Rat  1344 VNLLVGGFKCDCPSGDFEKPFCQVTTRSFPARSFITFRGLRQRFHFTLALSFATKERDGLLLYNG 1408

  Fly  2425 PIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFW------- 2482
            ......       ||:|||:.:...:|....|..|..:.......:.||:||.:.|.:       
  Rat  1409 RFNEKH-------DFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLG 1466

  Fly  2483 --------DTESIRMV-VDFCKSAEIAEMEDGTPPEFDDM----SCQARGQIPPFNEYLNVNAPL 2534
                    ..:.:.:| ||.|        :.|....|..|    ||.|:|......:.|::..||
  Rat  1467 QTGLPQGPSEQKVAVVSVDGC--------DTGVALRFGAMLGNYSCAAQGTQGGSKKSLDLTGPL 1523

  Fly  2535 QVGGL--YREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCA 2597
            .:||:  ..|.|...:         :.|.||::||..:|:..|:|....:..:|.|||..:.|| 
  Rat  1524 LLGGVPDLPESFPVRM---------RHFVGCMKNLQVDSRHVDMADFIANNGTVPGCPTKKNVC- 1578

  Fly  2598 QTETTARCWEHGNCVGSLSEARCHCRPGWTGPAC-----NIPTIPTTFKAQSYVK-YALSFEPDR 2656
               .:..|...|.||.......|.|..|:.|.:|     |    |..|...|.|. :.||. |..
  Rat  1579 ---DSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMAN----PQRFLGSSLVAWHGLSL-PIS 1635

  Fly  2657 FSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDG 2721
            ....:.|.||||:..|.|.:...: .|....|:::.||:..  ::.....:...|.|.....|||
  Rat  1636 QPWHLSLMFRTRQADGVLLQAVTR-GRSTITLQLRAGHVVL--SVEGTGLQASSLRLEPGRANDG 1697

  Fly  2722 QWHVVKVNRYGSAATLELDGGEGRRYNETFEFVGHQWLLVDKQEGVYAGGKAE-YTGVRTFEVYA 2785
            .||..::       :|...||.           ||..|..|     |...||| ..|.|...::.
  Rat  1698 DWHHAQL-------SLGASGGP-----------GHAILSFD-----YGQQKAEGNLGPRLHGLHL 1739

  Fly  2786 DYQ----------------KSCLDDIRL----EGKHLPLPPAMNGTQWGQATMARNLEKGCPSNK 2830
            ...                :.||..:|:    ||.. .|.|:.     |::.   |:|.||....
  Rat  1740 SNMTVGGVPGPASSVARGFRGCLQGVRVSETPEGVS-SLDPSR-----GESI---NVEPGCSWPD 1795

  Fly  2831 PCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPRLRY-- 2893
            ||.:..||....|.:.|:.|.|:|      .|...|....|.|...||.:.:.|.. :|...:  
  Rat  1796 PCDSNPCPTNSYCSNDWDSYSCSC------DPGYYGDNCTNVCDLNPCEHQSVCTR-KPSAPHGY 1853

  Fly  2894 --RCI---------------CPDGFWGE------NCEL 2908
              .|:               ||.|:||.      ||::
  Rat  1854 ICECLPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDV 1891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637 31/101 (31%)
Cadherin_repeat 1083..1166 CDD:206637 30/88 (34%)
Cadherin_repeat <1219..1298 CDD:206637 27/79 (34%)
Cadherin_repeat 1310..1414 CDD:206637 36/105 (34%)
Cadherin_repeat 1423..1514 CDD:206637 31/92 (34%)
Cadherin_repeat 1522..1630 CDD:206637 5/107 (5%)
Cadherin_repeat 1638..1741 CDD:206637 19/102 (19%)
Cadherin_repeat 1762..1861 CDD:206637 12/98 (12%)
Cadherin_repeat 1871..1966 CDD:206637 32/95 (34%)
Cadherin_repeat 1974..2083 CDD:206637 24/118 (20%)
EGF 2350..2380 CDD:278437 15/40 (38%)
LamG 2385..2570 CDD:238058 51/206 (25%)
EGF_2 <2605..2631 CDD:285248 8/25 (32%)
Laminin_G_2 2665..2800 CDD:280389 34/155 (22%)
EGF_CA 2869..2907 CDD:238011 13/62 (21%)
Cadherin_C 2952..3088 CDD:279398
Celsr2NP_001178039.1 Cadherin_repeat 185..285 CDD:206637 32/102 (31%)
Cadherin_repeat 293..395 CDD:206637 38/106 (36%)
Cadherin_repeat 404..501 CDD:206637 39/108 (36%)
Cadherin_repeat 509..606 CDD:206637 37/109 (34%)
Cadherin_repeat 614..708 CDD:206637 31/93 (33%)
Cadherin_repeat 716..811 CDD:206637 36/338 (11%)
Cadherin_repeat 819..917 CDD:206637 32/97 (33%)
Cadherin_repeat 925..1019 CDD:206637 24/118 (20%)
Cadherin_repeat 1042..1120 CDD:206637 21/90 (23%)
EGF_CA 1289..1324 CDD:238011 6/34 (18%)
EGF_CA 1333..1366 CDD:238011 14/32 (44%)
LamG 1369..1552 CDD:238058 51/206 (25%)
EGF_CA 1578..1609 CDD:238011 9/34 (26%)
LamG 1618..1767 CDD:238058 39/175 (22%)
EGF_CA 1795..1829 CDD:238011 11/39 (28%)
Keratin_B2 1806..1956 CDD:279797 21/93 (23%)
DSL <1819..1866 CDD:302925 10/53 (19%)
EGF_Lam 1924..1969 CDD:214543
HormR 1972..2034 CDD:214468
GAIN 2052..2287 CDD:293098
GPS 2315..2368 CDD:197639
7tm_4 2374..2605 CDD:304433
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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