DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN and Slit1

DIOPT Version :9

Sequence 1:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster
Sequence 2:	NP_075242.1	Gene:	Slit1 / 65047	RGDID:	69307	Length:	1531	Species:	Rattus norvegicus

Alignment Length:	357	Identity:	91/357 - (25%)
Similarity:	144/357 - (40%)	Gaps:	96/357 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2292 IDE-----CL----YENQMCEGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKP 2347
            :||     ||    |..|:|        ||.|.|                         ||
  Rat  1099 VDEINSYACLCAEGYSGQLC--------EIPPAP-------------------------RN---- 1126

  Fly  2348 ESCRTTPCHNGGRCVDTRFGPHCSCPVGYTGPRCQQ--TTRSFRGNGWAWYPPLEMCDESHLSLE 2410
             ||..|.|.||..|||....|.|.|..|:.||.|::  :......:.:..:..|:....::::|:
  Rat  1127 -SCEGTECQNGANCVDQGSRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQ 1190

  Fly  2411 FITRKPDGLIIYNGPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEW 2475
            ..|.:.:|:::|||.           :|.||:||.:|:.|:..|.||.. ...:.:.:|::||::
  Rat  1191 VSTAEDNGILLYNGD-----------NDHIAVELYQGHVRVSYDPGSYP-SSAIYSAETINDGQF 1243

  Fly  2476 HRIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEY--LNVNAPLQVGG 2538
            |.::|....:.:.:.:|           .|:|...|:           |.::  ||..|||.|||
  Rat  1244 HTVELVTFDQMVNLSID-----------GGSPMTMDN-----------FGKHYTLNSEAPLYVGG 1286

  Fly  2539 LYREQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQTETTA 2603
            :..:....:...|..: ....|.||||||..|::|.|.....:....|.||    |.|.:....
  Rat  1287 MPVDVNSAAFRLWQIL-NGTSFHGCIRNLYINNELQDFTKTQMKPGVVPGC----EPCRKLYCL- 1345

  Fly  2604 RCWEHGNCVGSLSEAR-CHCRPGWTGPACNIP 2634
                ||.|..:.:... |||..||.|..|:.|
  Rat  1346 ----HGICQPNATPGPVCHCEAGWGGLHCDQP 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637
		Cadherin_repeat	1423..1514	CDD:206637
		Cadherin_repeat	1522..1630	CDD:206637
		Cadherin_repeat	1638..1741	CDD:206637
		Cadherin_repeat	1762..1861	CDD:206637
		Cadherin_repeat	1871..1966	CDD:206637
		Cadherin_repeat	1974..2083	CDD:206637
		EGF	2350..2380	CDD:278437	13/29 (45%)
		LamG	2385..2570	CDD:238058	43/186 (23%)
		EGF_2	<2605..2631	CDD:285248	9/26 (35%)
		Laminin_G_2	2665..2800	CDD:280389
		EGF_CA	2869..2907	CDD:238011
		Cadherin_C	2952..3088	CDD:279398
Slit1	NP_075242.1	LRRNT	33..64	CDD:214470
		leucine-rich repeat	43..62	CDD:275380
		LRR_8	61..121	CDD:290566
		LRR 1	62..83
		leucine-rich repeat	63..86	CDD:275380
		LRR 2	86..107
		LRR_RI	<87..275	CDD:238064
		leucine-rich repeat	87..110	CDD:275380
		LRR_8	109..169	CDD:290566
		LRR 3	110..131
		leucine-rich repeat	111..134	CDD:275380
		LRR 4	134..155
		leucine-rich repeat	135..158	CDD:275380
		LRR 5	158..179
		LRR_8	159..217	CDD:290566
		leucine-rich repeat	159..182	CDD:275380
		LRR 6	182..203
		leucine-rich repeat	183..206	CDD:275380
		leucine-rich repeat	207..334	CDD:275380
		LRRNT	282..313	CDD:214470
		LRR 7	310..331
		LRR_8	312..369	CDD:290566
		LRR_4	334..373	CDD:289563
		LRR 8	334..355
		leucine-rich repeat	335..358	CDD:275380
		LRR 9	358..379
		leucine-rich repeat	359..379	CDD:275380
		LRR 10	382..403
		leucine-rich repeat	383..406	CDD:275380
		LRR_8	389..441	CDD:290566
		LRR_RI	<398..627	CDD:238064
		LRR 11	406..427
		leucine-rich repeat	407..428	CDD:275380
		leucine-rich repeat	431..528	CDD:275380
		leucine-rich repeat	529..566	CDD:275380
		LRR 12	541..562
		LRR_8	543..601	CDD:290566
		LRR_4	543..582	CDD:289563
		LRR 13	566..587
		leucine-rich repeat	567..590	CDD:275380
		LRR_8	589..649	CDD:290566
		LRR 14	590..611
		leucine-rich repeat	591..614	CDD:275380
		LRR 15	614..635
		LRR_4	615..654	CDD:289563
		leucine-rich repeat	615..638	CDD:275380
		LRR 16	638..659
		leucine-rich repeat	639..660	CDD:275380
		leucine-rich repeat	663..754	CDD:275380
		LRRCT	671..719	CDD:214507
		LRRNT	733..765	CDD:214470
		leucine-rich repeat	755..785	CDD:275380
		LRR_8	761..820	CDD:290566
		LRR 17	762..783
		LRR 18	785..806
		LRR_4	786..827	CDD:289563
		leucine-rich repeat	786..809	CDD:275380
		LRR 19	809..830
		leucine-rich repeat	810..830	CDD:275380
		LRR 20	833..854
		leucine-rich repeat	834..857	CDD:275380
		LRRCT	866..915	CDD:214507
		EGF_CA	927..962	CDD:238011
		EGF_CA	966..1002	CDD:238011
EGF_CA	1005..1041	CDD:238011
EGF_CA	1044..1080	CDD:238011
EGF_CA	1085..1119	CDD:238011	7/27 (26%)
LamG	1186..1319	CDD:214598	43/167 (26%)
GHB_like	<1494..1529	CDD:304424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910