DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and CDH23

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:NP_071407.4 Gene:CDH23 / 64072 HGNCID:13733 Length:3354 Species:Homo sapiens


Alignment Length:2450 Identity:640/2450 - (26%)
Similarity:987/2450 - (40%) Gaps:482/2450 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 EMSLVLPHDTYPGFS-----IKKFKTHPVKI---------NGSSHSGAAAYHMLDTDYSKYFTVL 121
            :::|:..:|..|.||     |..::...|..         |.:...|..:|...| |..::....
Human   447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD-DPDRFSLDK 510

  Fly   122 EDGVVMTTADIS-PLVNRPVQLVVVEQTPNATNTHNLQLFVMHRNDML-RFSGSLLDA-SGEVRE 183
            :.|::|..|.:. .|:.|....::.........|..:::.|:..||.: .|.   .|| .|.:||
Human   511 DTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQ---KDAYVGALRE 572

  Fly   184 NQPAGT---RVRGVPLMQAFSGSILDEELATPKKVRYTII---------DGNVDDAFAL------ 230
            |:|:.|   |:|..           ||:.....::.|:|:         |.::.:.:.:      
Human   573 NEPSVTQLVRLRAT-----------DEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRP 626

  Fly   231 --QERKAN-----------------------------------------------KNIQISAKSL 246
              .|:.:|                                               :||...|..|
Human   627 LDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691

  Fly   247 VINGDD---------ESGVW----------------LVTNRPLDREERAHYDLSVEASD--VDGL 284
            .:|..|         ||.::                :.|...||||.::.|.|.|.|.|  |...
Human   692 FLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756

  Fly   285 DRT-VSKIQITVLDENDNRPIFKSLDYKFAIAGQKSASMESNSSVTYQRFAIMGKVEATDAD-GD 347
            .:| ::.:.||:||.|||.|.:|...|...:.    .....:|.||        .|.|.|.| |:
Human   757 QKTGIATVNITLLDINDNHPTWKDAPYYINLV----EMTPPDSDVT--------TVVAVDPDLGE 809

  Fly   348 K--IAYRLKSPSNVVIIVPQTGEI-----MLAGE---PTSNELLIEVIAH--DLRYPSLVSAKPA 400
            .  :.|.::.|:....:...||:|     ||..|   |...||:.:::..  |...|.|.:...|
Human   810 NGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874

  Fly   401 KVLLEFLAAEPVSFIMQHLEHDDINNHSHHREKRRVTRAVRPT-KRIEFTE--ADGDTEGKSVFQ 462
            .|.:..|               |:|::.             || :.:.|..  .:|...|.|::|
Human   875 TVFVNLL---------------DLNDND-------------PTFQNLPFVAEVLEGIPAGVSIYQ 911

  Fly   463 LEKETDKETFKIRDDNPWVTVE----TNGAVRVK-----KKWDY------------EELGPEKTI 506
            :                 |.::    .||.|..:     .:.|:            .||..|:..
Human   912 V-----------------VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959

  Fly   507 DFWVIITNMGHNAGI-KYTDNQRVIILVKDVNDEPPYFINRPLPMQAVVQLNAPPNTPVFTLQAR 570
            ::.:.:  :..:||. ..:....:.|.|.|||||.|.|.  |......|..:.|....|..|...
Human   960 EYQLRV--VASDAGTPTKSSTSTLTIHVLDVNDETPTFF--PAVYNVSVSEDVPREFRVVWLNCT 1020

  Fly   571 DPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGTDLFQLDME----YVLYVKAEDQNGKVDD 629
            |.|...|  :.|||......|:|.|..|..||||    :..||.|    |:|.::|.| ||.| .
Human  1021 DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT----VVGLDRETTAAYMLILEAID-NGPV-G 1079

  Fly   630 RRFQSTPEERLSIVG-GKRAPQFYMPSYEAEIPENQKKDSDIISIKAKSFADRE---IRYTLKAQ 690
            :|...|....::::. ....|.|...||||.:||:..:...|:.:||....:.|   :.|.: ..
Human  1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI-LH 1143

  Fly   691 GQGAGTFNIGPTSG-IVKLAKELDFEDLRQPHVYSLIVTA-TEDSGGFSTSVDLTIRVTDVNDNA 753
            |.....|.|..::| :::..:.|| .:....||  |||.| ..|.|...:||.:.:.|.|:||.|
Human  1144 GNHGNNFRIHVSNGLLMRGPRPLD-RERNSSHV--LIVEAYNHDLGPMRSSVRVIVYVEDINDEA 1205

  Fly   754 PKFELPDYQAHNVDEDIPLGTSILRVKAMDSDSGSNAEIEYLV---SDDHFAVD-SNGIIVNNKQ 814
            |.|....|....:.|...:|||::.|:|.|.|||....:.|.:   ::..|.:| |.|:|:....
Human  1206 PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNY 1270

  Fly   815 LDADNNNAYYEFIVTAKDKGEPPKSGVATVRVYTKNKNDEEPKFSQQVYTPNVDENAGPNTLVTT 879
            ||.:...:|. ..|:|.|:..|...|..:|.:...|:.||..:||...|...:.||....|.:..
Human  1271 LDYETKTSYM-MNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVR 1334

  Fly   880 VVASDKDGDN---VRFGFVGGGTSSGQFVIEDITGVIRLHNKAISLDKDK---YELNVTAMDDGS 938
            |.|...|..|   .||.......:...|.|:.|||||.:..   .:|::|   |.|.|.| |||.
Human  1335 VQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQG---LVDREKGDFYTLTVVA-DDGG 1395

  Fly   939 CCVNGDQTIHTSTAVVVVFITDVNDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQ 1003
            ..|:       ||..|.:.:.|.|||.|.|...|.....:.|..|.|..|..|.|.|.|.|.|||
Human  1396 PKVD-------STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453

  Fly  1004 VKYSIVQQPNQKGT--KFTVDEETGEVSTNKVFDREGDDGKFVSVTVKATDQGDPSLEGVCSFTV 1066
            |.:|:. ..|..|.  ..|.::..|||...:..|||..|...:.|.  |:|:|.|..:......|
Human  1454 VVFSLA-SGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV--ASDRGTPPRKKDHILQV 1515

  Fly  1067 EITDVNDNPPLFDRQ-KYVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFE 1130
            .|.|:|||||:.:.. .|..:|.::...||.:::|.|:|.|...|..:.|.:|   ..|....|.
Human  1516 TILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT---EGNKDMAFR 1577

  Fly  1131 IQAESGWIVLKKPLDGCYPRDR-----YRLRVSASDKGTPASAADVDVELDVVDRNNKPPIWDKS 1190
            :...||.|..:..     |.||     |.|..:..|:|||..:|...|.:.:||.|:..|::.:.
Human  1578 MDRISGEIATRPA-----PPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQP 1637

  Fly  1191 IYGPIHIRENVTVGTVVTSVKASSGIEG-NPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWAD 1254
            .|..:......|:.|.:.:::|....|| |.||.|.::.|     |..:||.:.:.      ...
Human  1638 HYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAG-----NIVNTFRIDRH------MGV 1691

  Fly  1255 IKVNHPLDYE-SIKEYNLTIRVENNG---AQQLASEATVYIMLEDVNDEIPLFTEREQE---TVL 1312
            |.....|||| |...|.|.:...:..   :.:|.|..||.:.:.|:||.:|.| .|:.|   .|.
Human  1692 ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF-PRDYEGPFEVT 1755

  Fly  1313 EGEPIGTKVTQVNAIDKDGTFPNNQVYYYIVD-SPRNEGKEFFEINLQSGEIFTK--TVFDREKK 1374
            ||:| |.:|....|.|:| :.||.||.|.|:| .|..|    |.|:...|.:..:  ...|||..
Human  1756 EGQP-GPRVWTFLAHDRD-SGPNGQVEYSIMDGDPLGE----FVISPVEGVLRVRKDVELDRETI 1814

  Fly  1375 GAYALEVEARD-GAPSARPNSNGPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVL 1438
            ..|.|.:.||| |.|        |.|.|..:.|.:.|.|||.|..........:.||..:...|.
Human  1815 AFYNLTICARDRGMP--------PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVA 1871

  Fly  1439 TVTAKDHDE--SSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELRLAASDN----- 1496
            .|.|.|.|.  ::|:.:.||:||...||.:...||.:.|...||.|....|:|.::..||     
Human  1872 HVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 1936

  Fly  1497 -LKENYTTVIIHVKDVNDNPPVFERPTYRTQITEEDDRNLPKRVLQ--VTATDGDKDRPQNIVYF 1558
             .:.:|..::|.:.|.|||.|:|.:.||:.::.|......|..||.  :.|.|.|:|....:.|.
Human  1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ 2001

  Fly  1559 LTGQGIDPDNPANSKFDINRTTGEIFVLKP--LDRD--QPNGRPQWRFTVFAQDEGGEGLVGYAD 1619
            |.|       ..:..||||.:||.:.|...  :||:  .|   |.....:.|:|.|  .|...|.
Human  2002 LLG-------AQSGLFDINSSTGVVTVRSGVIIDREAFSP---PILELLLLAEDIG--LLNSTAH 2054

  Fly  1620 VQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVIEEE 1684
            :.:.:.|.|||.|.|.......::.||...|..|:.:||.|.|   .|.|..|||.||....:. 
Human  2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDED---SGLNGELVYRIEAGAQDR- 2115

  Fly  1685 TGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDGG--GLKGTGTASIRVKDINDMPPQFT 1747
                 |.|...||||:.....:|||....|.:.|||.|.|  .|.||...:|.:.||||..|:|.
Human  2116 -----FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFL 2175

  Fly  1748 KDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNSGYGA--DKFTMVRN-------N 1803
            .......|.|   :|.|...|..:|..|.|...|.:|.::   |..|  |...:|.|       |
Human  2176 NPIQTVSVLE---SAEPGTVIANITAIDHDLNPKLEYHIV---GIVAKDDTDRLVPNQEDAFAVN 2234

  Fly  1804 DGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPHFERA 1868
            ..|||:.:..|::.|  |.:. :...:.|.|...|.......|..:.:.|.:.|:|||.|.|:..
Human  2235 INTGSVMVKSPMNRE--LVAT-YEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPF 2296

  Fly  1869 NVEV---SVFEDTKVGTELEKFKATDPDQGGKSKVSYS-IDRSSDRQRQFAINQNGSVTIQRSLD 1929
            .:..   .:.|....||.|....|.|||:|....|:|: :|.......|...:..|.|...|::|
Human  2297 GITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVD 2361

  Fly  1930 REVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKF-LKDYRPVLPEHVPPRKVV-EILA 1992
            .|.|......:.|.|:||||:.|...:.:.:.|||||.|.| ...|:..:.|.||...:: .:.|
Human  2362 YEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTA 2426

  Fly  1993 TDDD-------DRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQ 2050
            ||.|       :.|..:|.. :|.::|:..||.                   |:|||   |||::
Human  2427 TDADSGNFALIEYSLGDGES-KFAINPTTGDIY-------------------VLSSL---DREKK 2468

  Fly  2051 KEYMIPIVIKDHGSPAMTG--TSTLTVIIG--DVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYV 2111
            ..|::..:.||:.....:.  .:::.|:|.  ||||.:.|..........|:.:...|.:..:..
Human  2469 DHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMA 2533

  Fly  2112 YDLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTRE-------------------GRYHLR 2157
            .|.|:....:..:..|......|.:|.|||:||.:...:.                   |...|.
Human  2534 TDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLL 2598

  Fly  2158 FKVYDRKHTQTDI--PANVTVT-VR-EIPHEAVVN-----------SGSVRLS-----GISDEDF 2202
            .:|.|....:...  |.|.|:. :| |||..:.|.           :|:||.|     |..|.:|
Human  2599 VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEF 2663

  Fly  2203 IRVWNYRTQSMSRSKMDRFRDKLADLLNT----ERENVDIFSVQL 2243
            ..:                 |.::.|:.|    :||:..::|:.|
Human  2664 FII-----------------DPISGLIQTAQRLDRESQAVYSLIL 2691

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637 40/217 (18%)
Cadherin_repeat 337..396 CDD:206637 19/71 (27%)
E_set 449..541 CDD:298831 21/115 (18%)
Cadherin_repeat 549..>625 CDD:206637 25/81 (31%)
Cadherin_repeat 655..752 CDD:206637 30/101 (30%)
Cadherin_repeat 765..853 CDD:206637 26/91 (29%)
Cadherin_repeat 862..964 CDD:206637 32/107 (30%)
Cadherin_repeat 973..1074 CDD:206637 33/102 (32%)
Cadherin_repeat 1083..1166 CDD:206637 24/87 (28%)
Cadherin_repeat <1219..1298 CDD:206637 21/82 (26%)
Cadherin_repeat 1310..1414 CDD:206637 37/107 (35%)
Cadherin_repeat 1423..1514 CDD:206637 28/98 (29%)
Cadherin_repeat 1522..1630 CDD:206637 31/113 (27%)
Cadherin_repeat 1638..1741 CDD:206637 36/104 (35%)
Cadherin_repeat 1762..1861 CDD:206637 27/107 (25%)
Cadherin_repeat 1871..1966 CDD:206637 29/98 (30%)
Cadherin_repeat 1974..2083 CDD:206637 29/120 (24%)
EGF 2350..2380 CDD:278437
LamG 2385..2570 CDD:238058
EGF_2 <2605..2631 CDD:285248
Laminin_G_2 2665..2800 CDD:280389
EGF_CA 2869..2907 CDD:238011
Cadherin_C 2952..3088 CDD:279398
CDH23NP_071407.4 Cadherin_repeat 42..128 CDD:206637
Cadherin_repeat 136..231 CDD:206637
Cadherin_repeat 240..344 CDD:206637
Cadherin_repeat 352..456 CDD:206637 1/8 (13%)
Cadherin_repeat 465..557 CDD:206637 15/92 (16%)
Cadherin_repeat 566..667 CDD:206637 15/111 (14%)
Cadherin_repeat 676..774 CDD:206637 25/97 (26%)
Cadherin_repeat 782..886 CDD:206637 28/130 (22%)
Cadherin_repeat 894..990 CDD:206637 19/114 (17%)
Cadherin_repeat 999..1098 CDD:206637 30/104 (29%)
Cadherin_repeat 1106..1203 CDD:206637 29/100 (29%)
Cadherin_repeat 1218..1308 CDD:206637 26/90 (29%)
Cadherin_repeat 1317..1414 CDD:206637 32/107 (30%)
Cadherin_repeat 1426..1523 CDD:206637 33/99 (33%)
Cadherin_repeat 1533..1630 CDD:206637 30/104 (29%)
Cadherin_repeat 1638..1740 CDD:206637 28/112 (25%)
Cadherin_repeat 1752..1847 CDD:206637 37/108 (34%)
Cadherin_repeat 1855..1955 CDD:206637 28/99 (28%)
Cadherin_repeat 1963..2065 CDD:206637 31/113 (27%)
Cadherin_repeat 2075..2169 CDD:206637 36/102 (35%)
Cadherin_repeat 2180..2289 CDD:206637 29/117 (25%)
Cadherin_repeat 2301..2398 CDD:206637 29/96 (30%)
Cadherin_repeat 2406..2504 CDD:206637 28/120 (23%)
Cadherin_repeat 2513..2607 CDD:206637 16/93 (17%)
Cadherin_repeat 2620..2718 CDD:206637 18/88 (20%)
Cadherin_repeat 2735..2841 CDD:206637
Cadherin_repeat 2850..2951 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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