DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN and Nrxn1

DIOPT Version :9

Sequence 1:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster
Sequence 2:XP_038968743.1 Gene:Nrxn1 / 60391 RGDID:628659 Length:1516 Species:Rattus norvegicus


Alignment Length:1688 Identity:344/1688 - (20%)
Similarity:538/1688 - (31%) Gaps:597/1688 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1596 GRPQWRFTVFAQDEGGEGLVGYADVQVN-----------------------------LKDINDNA 1631
            ||.|..|::|.    .|.....||..||                             :|....:.
  Rat    87 GRLQLSFSIFC----AEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVEVKSKRRDM 147

  Fly  1632 PIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEG---------SNARLVYSIEKNVIEEET-- 1685
            .:| .|::.|.:.....|..:.:|:.:|...:|.:|         |.|..|...|..:.||..  
  Rat   148 TVF-SGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGSEVKLDEEPPNS 211

  Fly  1686 --GSPIFEI--EPDTGV-IKTAVCCL-------DRERT---------PDYSIQVVAM----DGGG 1725
              |||. |.  |.|.|| :...||.:       |..||         .|.:::.:|.    |.|.
  Rat   212 GGGSPC-EAGDEGDGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGK 275

  Fly  1726 LKGTGTASIRVK-------DINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQ 1783
            .||........|       |::..|.|.:.||                    :|:         .
  Rat   276 SKGKEEYIATFKGSEYFCYDLSQNPIQSSSDE--------------------ITL---------S 311

  Fly  1784 YKVID------NSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQ-VNDKGEDNDN 1841
            :|.:.      ::|..||...:...| |..||.|        .|.|..|...:: ||.|..||  
  Rat   312 FKTLQRNGLMLHTGKSADYVNLALKN-GAVSLVI--------NLGSGAFEALVEPVNGKFNDN-- 365

  Fly  1842 DKYHVAYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDR 1906
                   :|                         .|.||...|.:....     |.:.|:.|:| 
  Rat   366 -------AW-------------------------HDVKVTRNLRQHSGI-----GHAMVTISVD- 392

  Fly  1907 SSDRQRQFAINQNGSVTIQRSLDREVVPRHQVKILAIDD-----GSPPKTATATLTVIVQDINDN 1966
                         |.:|.......:..      :|..||     |||   :||.|.  ...:::|
  Rat   393 -------------GILTTTGYTQEDYT------MLGSDDFFYVGGSP---STADLP--GSPVSNN 433

  Fly  1967 APKFLKDYRPVLPEHVPPRKVVEILATDDDDRSKSNG------------PPFQFRLDPSADDIIR 2019
               |:...:.|:.::...|..:..||...|.:.|.:|            .|..|....|...:.:
  Rat   434 ---FMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPK 495

  Fly  2020 ASFK----VEQDQKGANGDGMAVISSLRSFDREQQKEYMIPIVIK-----------------DHG 2063
            .:.|    :..|.:....:|:.:.|..:.   ..||:...|.:||                 |.|
  Rat   496 WNAKKTGSISFDFRTTEPNGLILFSHGKP---RHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMG 557

  Fly  2064 SPAMTGTSTLTVIIGDVNDNK------MQPGSKDIFVYNYQGQSPDTPIGRVYVYDLDD----WD 2118
            |    ||..:..:...|||.:      .:.|.......|.. ::|.|..|...:.||||    ..
  Rat   558 S----GTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTL-RTPYTAPGESEILDLDDELYLGG 617

  Fly  2119 LPDKKF-------YWEAMEHPRFK-------LDEDSGMVTMRAGTREGRYHLRFKVYDRKHTQTD 2169
            ||:.|.       .|.|:.:..:.       :|..|..:...|              :.:.|...
  Rat   618 LPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA--------------EIQSTAGV 668

  Fly  2170 IPANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWN----------YRTQSMSRSKMDRFRD- 2223
            .|:....|.:........|:|..| .|         ||          |..:|..|.......| 
  Rat   669 KPSCSRETAKPCLSNPCKNNGMCR-DG---------WNRYVCDCSGTGYLGRSCEREATVLSYDG 723

  Fly  2224 ------KLADLLNTERENVDIFSVQLKRKHPPLTDVRFSAHGSPYYKPVRLNGIVLMHRE----- 2277
                  :|..:::||.|:|.:               ||.:.        |..||::....     
  Rat   724 SMFMKIQLPVVMHTEAEDVSL---------------RFRSQ--------RAYGILMATTSRDSAD 765

  Fly  2278 --EIEKDVG-INITMVGIDECLYENQMCEGSCTNSLEISPLPYMVNANKTALVGVRV-------- 2331
              .:|.|.| :.:| |.:| |:..|      |.:|.....|....|.|......|||        
  Rat   766 TLRLELDAGRVKLT-VNLD-CIRIN------CNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLK 822

  Fly  2332 ----DTIADCTCGARNFTKPESCRTTPCHN--GGRCVDTRFGPHCSCPVGYTGPRCQQTTRSFRG 2390
                |..|.....|.:.|:.|      .||  .|...:.|:  ..|.|..:.|     ..:|...
  Rat   823 LTVDDQQAMTGQMAGDHTRLE------FHNIETGIITERRY--LSSVPSNFIG-----HLQSLTF 874

  Fly  2391 NGWAWYPPLEMCDES-----------------------------------------HLSLEFITR 2414
            ||.|:   :::|...                                         ||..:|.|.
  Rat   875 NGMAY---IDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTT 936

  Fly  2415 KPDGLIIYN---GPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWH 2476
            ..||||:||   |            :|||.:||.:||...:.|.|:|...::..:.|.|:|.:||
  Rat   937 SLDGLILYNSGDG------------NDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWH 989

  Fly  2477 RIDLFWDTESIRMVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYR 2541
            .:.:..||.::..|                     .:..:...||......|::.:.|.:||:.:
  Rat   990 NVMISRDTSNLHTV---------------------KIDTKITTQITAGARNLDLKSDLYIGGVAK 1033

  Fly  2542 EQFDQSLYFWHYMPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQT------- 2599
            |.:.......|   ..:||.||:.::..|.:|.||....|..|.     |.|..|...       
  Rat  1034 ETYKSLPKLVH---AKEGFQGCLASVDLNGRLPDLISDALFCNG-----QIERGCEVALMKADLQ 1090

  Fly  2600 --ETTAR---CWEHGNCVGSLSEARCHC-RPGWTGPACNIPTIPTTFK---AQSYVKYALSFEPD 2655
              .||.:   |...|.|:.......|.| ...::||.||.|.....|.   .|...|:..:..|.
  Rat  1091 GPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPS 1155

  Fly  2656 RFSTQVQLRFRTREEYGELFRV-SDQHNREYGILEIKDGHLHFRYNL--NSLRTEEKDLWLNAIV 2717
            ..:.::.:.|.|.::...|.|| |.....:|..|.|..|.:..::|:  :.:..||.    ||| 
  Rat  1156 TRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEES----NAI- 1215

  Fly  2718 VNDGQWHVVKVNRYGSAATLELDG-------GEGRRYNETFEF-----------VGHQWLLVDK- 2763
            :|||::|||:..|.|..|||::|.       ..|...||....           |..:||| || 
  Rat  1216 INDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLL-DKG 1279

  Fly  2764 --------QEGVYAGGKAE------------YTGVRTFEVYA--DYQKSCLDDIRLEGKHLPLPP 2806
                    |..:..|||.:            |.|::...:.|  |...:.:.::||.|:   :|.
  Rat  1280 RQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGE---VPS 1341

  Fly  2807 AMNGTQWGQA--------------TMARN-LEKGCPSNK-PCSNVI---------CPDPFECVDL 2846
            :|.......|              |:|.: ..:|.|..| |.|...         ||...|.:| 
  Rat  1342 SMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDID- 1405

  Fly  2847 WNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATCINLEPRLRYRCICPDGFWGENCELVQE 2911
                .|....|.:.:|...|                   ..||            :..:.|:::|
  Rat  1406 ----PCEPSSGGLANPTRVG-------------------GREP------------YPGSAEVIRE 1435

  Fly  2912 -GQTLKLSMGALAAILVCLLIILILVLVFVVYNRRREA--HIKYPGPDDDVRENIINYDDEGG 2971
             ..|..:.:|.:||..:|   ||||:.....|..|.|.  |:      |:.|..|.|.....|
  Rat  1436 SSSTTGMVVGIVAAAALC---ILILLYAMYKYRNRDEGSYHV------DESRNYISNSAQSNG 1489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
Cadherin_repeat 337..396 CDD:206637
E_set 449..541 CDD:298831
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637
Cadherin_repeat 1522..1630 CDD:206637 11/62 (18%)
Cadherin_repeat 1638..1741 CDD:206637 33/145 (23%)
Cadherin_repeat 1762..1861 CDD:206637 19/105 (18%)
Cadherin_repeat 1871..1966 CDD:206637 19/99 (19%)
Cadherin_repeat 1974..2083 CDD:206637 26/141 (18%)
EGF 2350..2380 CDD:278437 7/31 (23%)
LamG 2385..2570 CDD:238058 46/228 (20%)
EGF_2 <2605..2631 CDD:285248 7/26 (27%)
Laminin_G_2 2665..2800 CDD:280389 47/178 (26%)
EGF_CA 2869..2907 CDD:238011 2/37 (5%)
Cadherin_C 2952..3088 CDD:279398 5/20 (25%)
Nrxn1XP_038968743.1 LamG 30..190 CDD:238058 19/107 (18%)
LamG 307..446 CDD:214598 42/243 (17%)
LamG 503..652 CDD:214598 31/156 (20%)
EGF_CA 680..713 CDD:238011 8/42 (19%)
LamG 741..877 CDD:214598 36/179 (20%)
Laminin_G_2 933..1061 CDD:396680 40/163 (25%)
LamG 1134..>1253 CDD:238058 33/123 (27%)
Syndecan 1441..>1476 CDD:395821 12/43 (28%)
4.1m 1461..1479 CDD:128590 5/23 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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